Tritium in [18O]water containing [18F]fluoride for [18F]FDG synthesis

Ito, Shigeki; Saze, Takuya; Sakane, Hitoshi; Ito, Satoshi; Ito, Shin‐ichi; Nishizawa, Kunihide

doi:10.1016/j.apradiso.2004.04.002

Cited by 21 publications

(47 citation statements)

References 13 publications

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“…These results confirm the hypothesis that Havar is a major source of radionuclidic contamination [7][8][9][11][12][13][14][15][16]. Other identified isotopes are 48 V and 7 Be.…”

Section: Resultssupporting

confidence: 90%

“…The 56 Co isotope was observed in the final product, but the activity was too small for quantification. Some ambiguities arose for 55 Co, which was observed by some authors [8,9,14,16]. The measured activities are highly variable and the distribution between the anionic and cationic form varies, compared to the other cobalt isotopes.…”

Section: Resultsmentioning

confidence: 88%

“…The standard set of radionuclides: 52 Mn, 56 Co, 57 Co, 58 Co, 51 Cr, 96 Tc and 183 Re is consistent [7][8][9][11][12][13][14][15][16] and these isotopes give the largest contribution to the total activity of radionuclidic impurities. However, the full package of the impurities is very variable and the number of identified nuclides varies greatly between different authors.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Distribution and separation of metallic and radionuclidic impurities in the production of 18F-fluorodeoxyglucose

Kilian

Pęgier

Pękal

et al. 2015

J Radioanal Nucl Chem

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In this study the identification, determination and distribution of metallic and radionuclidic contaminants in the synthesis of 18 F-fluorodeoxyglucose are presented. Samples of irradiated 18 O-enriched water, purification columns (anionic, C18, Al 2 O 3 ), final product and wastes were examined. Metallic contaminants were determined by ICP-MS and the radionuclide impurities by high resolution germanium gamma-spectrometry. Fifteen radionuclides were identified in the samples. The enriched water contained cationic contaminants ( 55 Co, 56 Co, 57 Co, 58 Co, 57 Ni, 52 Mn, 7 Be) while the anionic ( 95 Tc, 95m Tc, 96 Tc, 183 Re) were mostly retained in the QMA column. The sources of contamination by metals and radionuclides were determined. Results obtained by ICP-MS generally confirmed the radionuclide distribution obtained by gamma spectrometry.

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“…These results confirm the hypothesis that Havar is a major source of radionuclidic contamination [7][8][9][11][12][13][14][15][16]. Other identified isotopes are 48 V and 7 Be.…”

Section: Resultssupporting

confidence: 90%

Section: Resultsmentioning

confidence: 88%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Distribution and separation of metallic and radionuclidic impurities in the production of 18F-fluorodeoxyglucose

Kilian

Pęgier

Pękal

et al. 2015

J Radioanal Nucl Chem

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“…PET diagnostic techniques use ␤+ emitting isotopes for labeling biologically active compounds and track their distribution in a living was 4.0 ± 0.2 Ci (140.6-155.4 GBq) after 120 min of irradiation and was transferred to the GE MX FDG unit (General Electric, Liege, Belgium), where the synthesis and purification were performed. In the synthesis path, the 18 F-fluoride solution was passed through an ion exchange column, which trapped anions. Cations, including some metal contaminants, were collected with the recovered enriched water.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, quality control and determination of metallic impurities in 18F-fludeoxyglucose production process

Kilian

Chabecki

Kiec

et al. 2014

Reports of Practical Oncology & Radiotherapy

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“…2 5,6) To identify the radionuclides of these by-products and to quantify their activities are necessary from the perspective of waste management and radiological protection to patients and operators.…”

Section: Introductionmentioning

confidence: 99%

Measurement of the Induced Radionuclides in Production of Radiopharmaceuticals for Positron Emission Tomography (PET)

Mochizuki

Ogata

Hatano

et al. 2006

Journal of Nuclear Science and Technology

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The radioactive by-products contained in an entire series of target foil, [ 18 O]H 2 O and synthesis apparatus were identified and quantified. From the perspective of waste management, 60 Co induced in Havar foil should be taken into consideration. Because the exempt activity of 60 Co in BSS is 0.1 MBq, the used Havar foil should be managed more than for 20 years. The radionuclides in the [ 18 F]-FDG synthesis apparatus are negligible. Equivalent doses at skin and to tissues were estimated assuming a point source at a distance of 30 cm in air. The annual equivalent doses at skin and equivalent dose at deep tissues of such an operating staff will be 56 and 8.3 mSv, respectively, as two times the remove of the target foil and five hundreds times the synthesis of the [ 18 F]-FDG. When proper radiation protection is provided, the exposure from the cyclotron management and the [ 18 F]-FDG synthesis process will not cause meaningful radiological risk to the operating staff. The activity concentration of 3 H, 180 kBqÁcm À3 , detected in the target water, is 3,000 times the legal limit of effluent for 3 H. The operators should take care of the treatment of the target water when they make a distillation for reuse and a disposal.

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Tritium in [18O]water containing [18F]fluoride for [18F]FDG synthesis

Cited by 21 publications

References 13 publications

Distribution and separation of metallic and radionuclidic impurities in the production of 18F-fluorodeoxyglucose

Distribution and separation of metallic and radionuclidic impurities in the production of 18F-fluorodeoxyglucose

Synthesis, quality control and determination of metallic impurities in 18F-fludeoxyglucose production process

Measurement of the Induced Radionuclides in Production of Radiopharmaceuticals for Positron Emission Tomography (PET)

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