Triterpenoids and iridoids from Patrinia scabiosaefolia

Liu, Zhenhua; Ma, Ruijing; Liu, Yang; Li, Jinyu; Hou, Bo; Hu, Jiang‐Miao; Zhou, Jun

doi:10.1016/j.fitote.2017.04.011

Cited by 17 publications

(8 citation statements)

References 17 publications

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“…Previous investigations showed that some iridoids from P. heterophylla and P. scabra possessed significant anti-inflammatory activity [ 35 , 36 , 37 ]. However, studies on the iridoids in P. scabiosifolia were mainly focused on their cytotoxic and AChE inhibitory activities, and studies on the anti-inflammatory activity of the iridoids from this plant are still insufficient [ 22 , 25 ]. In our work, eight compounds were isolated from P. scabiosifolia .…”

Section: Resultsmentioning

confidence: 99%

“…The whole plants of P. scabiosifolia have been used as traditional Chinese medicine to treat appendicitis, diarrhea, and postpartum abdominal pain [ 13 ]. Previous phytochemical investigations on P. scabiosifolia led to the isolation of triterpenoids [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ], iridoids [ 21 , 22 , 23 , 24 , 25 ], flavonoids [ 21 ], and lignans [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

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Two New Iridoid Glucosides from the Whole Plant of Patrinia scabiosifolia Link

Sun

Liu

et al. 2021

Molecules

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As a traditional Chinese medicine, Patrinia scabiosifolia Link has been used to treat various inflammatory-related diseases, and recent studies have shown that it possesses potent anti-inflammatory activity. Therefore, phytochemical investigation on whole plants of P. scabiosifolia were carried out, which led to the isolation of two new iridoid glucosides, patriniscabiosides A (1) and B (2), together with six known compounds (3–8). The structural elucidation of all compounds was performed by HRESIMS and extensive spectroscopic analyses including IR, 1D, 2D NMR, and electronic circular dichroism (ECD). All the isolated compounds were tested for their anti-inflammatory activity using the NF-κB-Dependent Reporter Gene Expression Assay, and compound 3 displayed anti-inflammatory activity through the inhibition of the NF-κB pathway, with an inhibitory rate of 73.44% at a concentration of 10 μM.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Two New Iridoid Glucosides from the Whole Plant of Patrinia scabiosifolia Link

Sun

Liu

et al. 2021

Molecules

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“…Second, we did not identify the specific mechanism or major components of the extracts derived from PS and HR. According to recent reports, PS contains several functional phytochemicals including iridoids, flavonoids, sterols, and pentacyclic triterpenoid saponins (Kang, Kim, Kim, & Choi, 1997; Liu et al, 2017). New triterpenoid saponins are continually identified (Gao et al, 2011) and demonstrate antiplatelet, ‐tumoral, ‐inflammatory, ‐bacterial, ‐HIV, and ‐hypercholesterolemic effects (Yendo et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Antiobesity effects of the combination ofPatrinia scabiosaefoliaroot andHippophae rhamnoidesleaf extracts

et al. 2020

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Patrinia scabiosaefolia (PS) and Hippophae rhamnoides (HR) are traditionally used functional foods. Extracts from the root of PS are known for their anti-inflammatory effects, whereas those from the leaf of HR are effective at both preventing and treating obesity. This study investigated whether the extract combination of PS and HR (PHE) affected weight loss in obese mice. In vitro experiments demonstrated that PHE showed a synergistic effect on inhibiting adipocyte differentiation as compared with treatment with the single extracts. Additionally, PHE suppressed adipogenicrelated genes in a concentration-dependent manner. In vivo PHE supplementation suppressed body weight gain, inhibited hepatic lipid accumulation, decreased adipose size, serum triglycerides, and improved insulin resistance in obese mice. These results suggest that a treatment strategy using a combination of plant-derived extracts might be effective at ameliorating obesity. Practical applicationsCurrently, common methods for reducing obesity are diet and exercise. These can stimulate oxidative phosphorylation and metabolic activation so have significantly effects. However, these are largely due to individual compliance; there is no significant effect of reducing the worldwide obesity rate. Recently, herbal extracts has been reported as alternative medicine about inflammatory and obesity because diet with the herbal extracts can improve obesity with minimal side effects. Of particular, a mixture of herbal products was investigated for the treatment of obesity. Our reports demonstrated the synergistic effects of natural products and emphasizes the need for studies investigating other combinations of herbal extracts in the treatment of obesity. The results of our studies highlight the synergistic effects of combination phytochemical extracts and their role in ameliorating obesity.

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“…The following technologies and materials were used in this research: UV spectra (Shimadzu, Kyoto, Japan); IR spectra (Bruker Vector 22 spectrophotometer, Bruker Optics GmbH, Ettlingen, Germany); Mass spectra (API QSTAR time-of-flight spectrometer, MDS Sciqaszex, Concord, Ontario, Canada). NMR spectra (Bruker AM-400, Bremerhaven, Germany); silica gel (200-300 and 300-400 mesh, Qingdao Marine Chemical Inc., China); Rp-18 gel (40-63 µm, Merck, Darmstadt, Germany); Sephadex LH-20 (20-150 µm, Amersham Biosciences, Uppsala, Sweden); YMC * GEL ODS-A-HG (50 µm, YMC Co. Ltd., Kyoto, Japan) (34).…”

Section: Reagents and Instrumentsmentioning

confidence: 99%

Nigella sativa: A Dietary Supplement as an Immune-Modulator on the Basis of Bioactive Components

et al. 2021

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Nutrients can be considered as functional foods, which exert physiological benefits on immune system. The seeds of Nigella sativa, which have many active constituents, are mainly used for medicine, food spice, and nutritional supplements in Egypt. Much attention has been paid to N. sativa seeds for their anticancer, antibacterial, anti-inflammatory, and immune properties. However, their active constituents and mechanisms underlying functions from N. sativa seeds is unclear. Thus, the bioactive constituents with immune regulation in N. sativa seeds were systematically studied. A new compound (3-methoxythymol-6-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside 1) and 11 known compounds (2–12) were separated from the N. sativa seeds by chromatographic methods. Their structures were then elucidated by spectroscopic analysis of MS, UV, IR, 1H-, and 13C-NMR. Furthermore, immunomodulatory effects of those compounds in RAW 264.7 cells were evaluated by phagocytosis, nitric oxide (NO) and cytokine release, related mRNA transcription, and key proteins expression in vitro. Monosaccharide derivatives, Ethyl-α-D-furaarabinose (5), and Ethyl-β-D-fructofuranoside (8) were shown to played bidirectional regulatory roles in immunity and anti-inflammation through the regulation of nuclear factor-κB (NF-κB) signaling pathways. The results showed the active compounds and mechanisms of immune regulation in N. sativa, thus indicating that N. sativa seeds could be used as dietary supplements in immunomodulation.

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Triterpenoids and iridoids from Patrinia scabiosaefolia

Cited by 17 publications

References 17 publications

Two New Iridoid Glucosides from the Whole Plant of Patrinia scabiosifolia Link

Two New Iridoid Glucosides from the Whole Plant of Patrinia scabiosifolia Link

Antiobesity effects of the combination ofPatrinia scabiosaefoliaroot andHippophae rhamnoidesleaf extracts

Nigella sativa: A Dietary Supplement as an Immune-Modulator on the Basis of Bioactive Components

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