Antiobesity effects of the combination ofPatrinia scabiosaefoliaroot andHippophae rhamnoidesleaf extracts

Abstract

Patrinia scabiosaefolia (PS) and Hippophae rhamnoides (HR) are traditionally used functional foods. Extracts from the root of PS are known for their anti-inflammatory effects, whereas those from the leaf of HR are effective at both preventing and treating obesity. This study investigated whether the extract combination of PS and HR (PHE) affected weight loss in obese mice. In vitro experiments demonstrated that PHE showed a synergistic effect on inhibiting adipocyte differentiation as compared with treatment with the single extracts. Additionally, PHE suppressed adipogenicrelated genes in a concentration-dependent manner. In vivo PHE supplementation suppressed body weight gain, inhibited hepatic lipid accumulation, decreased adipose size, serum triglycerides, and improved insulin resistance in obese mice. These results suggest that a treatment strategy using a combination of plant-derived extracts might be effective at ameliorating obesity. Practical applicationsCurrently, common methods for reducing obesity are diet and exercise. These can stimulate oxidative phosphorylation and metabolic activation so have significantly effects. However, these are largely due to individual compliance; there is no significant effect of reducing the worldwide obesity rate. Recently, herbal extracts has been reported as alternative medicine about inflammatory and obesity because diet with the herbal extracts can improve obesity with minimal side effects. Of particular, a mixture of herbal products was investigated for the treatment of obesity. Our reports demonstrated the synergistic effects of natural products and emphasizes the need for studies investigating other combinations of herbal extracts in the treatment of obesity. The results of our studies highlight the synergistic effects of combination phytochemical extracts and their role in ameliorating obesity.

Anti-Obesity Effects of Morus alba L. and Aronia melanocarpa in a High-Fat Diet-Induced Obese C57BL/6J Mouse Model

“…Combined treatment with extracts from these two plant species could have a synergistic effect. Choi et al showed that Patrinia scabiosaefolia and Hippophae rhamnoides extracts had a synergistic anti-obesity effect [19]. Similarly, crocin, chlorogenic acid, geniposide, and quercetin have been shown to reduce lipid accumulation in hepatic cells [20].…”

Evaluation of Antioxidative and Neuroprotective Activities of Total Flavonoids From Sea Buckthorn (Hippophae rhamnoides L.)

“…The main components of TFH is isorhamnetin, and the purity is more than 95%. The concentration of TFH solution [dissolved in Dimethyl sulfoxide (DMSO)] used in this study was 10, 20, and 50 μg/ml ( 8 , 9 ). Other chemical regents used in this study were obtained from Sigma-Aldrich Merck (Sigma-Aldrich, St. Louis, MO, United States).…”

Codium fragile reduces adipose tissue expansion and fatty liver incidence by downregulating adipo‐ and lipogenesis

“…Lipid extraction from the liver was performed based on the Folch method (Folch et al, 1957). Liver samples were homogenized in 0.9% NaCl and incubated overnight at 4 °C in a 20‐fold volume of the chloroform‐methanol mixture (2:1, v/v) (Choi et al, 2020). Chloroform‐soaked filter paper (No.…”