Triterpenes involved in the anti-inflammatory effect of ethanolic extract of Pterodon emarginatus Vogel stem bark

Moraes, Weuller F. de; Galdino, Pablinny Moreira; Nascimento, Marcus Vinícius Mariano; Vanderlinde, Frederico Argollo; Bara, Maria Teresa Freitas; Costa, Élson Alves; Paula, José Realino de

doi:10.1007/s11418-011-0547-5

Cited by 29 publications

(14 citation statements)

References 23 publications

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“…The description of the influence of lupeol and botulin in the anti-inflammatory properties of ethanol extract were also reported. 43 Our results demonstrated the influence of geranylgeraniol in the intensity of anti-inflammatory activity under edematogenic mechanisms. The early phase starts immediately after carrageenan injection and lasts for approximately 6 h, also leads to activation and secretion of mediators that include bradykinin and arachidonic acid metabolites such as prostaglandins and leukotrienes.…”

Section: Discussionsupporting

confidence: 55%

Comparison of Standardized Dichloromethane with Aqueous Pterodon pubescens Benth. Fruit Extracts on Antinociceptive and Anti-Inflammatory Activity

Grando¹,

Souza²,

Monteiro³

et al. 2016

J. Braz. Chem. Soc.

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Pterodon pubescens Benth., popularly known as "sucupira", is traditionally used as pain healing agent for many inflammatory diseases. The present study evaluated the in vivo antinociceptive and anti-inflammatory properties of sucupira's fruit dicloromethane extract (Pp) compared to the aqueous extract (Ppa) traditionally used in folk medicine. Extracts' chemical characterization was performed by gas chromatography coupled to mass spectra (GC-MS) detection. The standardized extracts were evaluated using antinociceptive and anti-inflammatory experimental models with mice. The results reported herein allowed establishing a relationship between the popular use of Pterodon pubescens fruit for pain relief and the activity of two major compounds isolated from this species which demonstrated antinociceptive activity. The experimental models corroborate activity of aqueous extract antinociceptive and anti-inflammatory activity, with lower potency compared to dichloromethane extract. Nevertheless the resulting data corroborates sucupira's folk use for pain relief.Keywords: Pterodon pubescens Benth., antinociceptive, furanditerpenes, sucupira, biological and pharmacological activities IntroductionThe study of inflammatory pain has been one of the most rapidly advancing and expanding areas of pain research. The chronic rheumatoid arthritis affects approximately 0.5-1% of the population, being among the main causes of adult disabilities characterized by spontaneity as well as lowered pain thresholds and increased sensitivity to pressure and temperature. [1][2][3][4][5] Chronic pain differs from acute pain not only in onset and duration, but more importantly in the underlying mechanisms, poorly responding to the usual drugs for acute pain. In order to improve chronic pain diseases treatment, a clear understanding of what leads to such persistent pain (visceral, inflammatory, and neuropathic) is required. Therefore testing pharmacological agents in such settings is the best way to explore new drug leads for chronic pain relief. An important source for this purpose is medicinal plants. 6 Pterodon pubescens' fruit decoction is widely used in Brazilian folk medicine for treatment of several chronic diseases such as rheumatism and arthritis. 7,8 The pharmacological properties of extracts, fractions and compounds obtained from P. pubescens have been reported for anti-parasitic, antitumor, anti-inflammatory, and antinociceptive activities.7-25 However, there is no scientific evidence reported concerning the antinociceptive and anti-inflammatory effectiveness of the aqueous extract or data supporting the ethno pharmacological use. Therefore, herein the differences in chemical profile, in vivo analgesic and anti-inflammatory properties of Freeze-dried fruit (100 g) were ground prior to use in a Stephen mill (model UM 40) and extracted with dichloromethane by soxhlet extraction system using a 1:3 ratio on mass basis (ground fruit:solvent). Subsequently the extract was concentrated under vacuum (Buchi RE 120) yielding 32% crude extract....

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Section: Discussionsupporting

confidence: 55%

Comparison of Standardized Dichloromethane with Aqueous Pterodon pubescens Benth. Fruit Extracts on Antinociceptive and Anti-Inflammatory Activity

Grando¹,

Souza²,

Monteiro³

et al. 2016

J. Braz. Chem. Soc.

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“…The oleaginous extract of the seeds also showed antinociceptive and anti-inflammatory properties, which were thought to be attributed to furane diterpene derivatives of vouacapan and non-vouacapan compounds (Coelho et al 2005;Galceran et al 2011). Triterpenes were suggested to be responsible for the anti-inflammatory effect in the extract from the P. emarginatus bark (Moraes et al 2012).…”

Section: Introductionmentioning

confidence: 96%

“…The phytochemical analyses of P. emarginatus showed the presence of terpenoids (furane diterpene derivatives) (Coelho et al 2005;Galceran et al 2011) and phenolic compounds (flavonoids and isoflavones) (Dutra et al 2009) in the fruits and seeds. Flavonoids, saponin heterosides (Bustamante et al 2010) and triterpenes, including lupeol and betulin (Moraes et al 2012), were identified in the bark.…”

Section: Introductionmentioning

confidence: 99%

Antinociceptive activity of the HPLC- and MS-standardized hydroethanolic extract of Pterodon emarginatus Vogel leaves

2014

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Several studies have demonstrated the analgesic and anti-inflammatory effects of fruit and seed extracts from Pterodon emarginatus Vogel (Fabaceae). The objective of this study was to evaluate the antinociceptive activity of the hydroethanolic extract of P. emarginatus leaves in mice and characterize its chemical composition using HPLC coupled to UV-vis diode array detection and mass spectrometry with electrospray ionization. Our results showed that the doses of 500 and 1000 mg/kg produced an antinociceptive effect, as observed in the hot plate test and writhing induced by acetic acid. The chromatographic profile and spectral mass data suggest the presence of di-C-glycosylflavones (e.g., vicenin-2 and schaftoside), C,O-glycosylflavones (e.g., chrysoeriol-8-C-glucosyl-2″-O-glucuronide-6-C-arabinoside) and luteolin-7-O-rutinoside as the main constituents. Lower levels of oleanane-type saponins, such as soyasaponin Bb and Be, and the saponin derivatives hederagenin and aglycone B, which are typical of Fabaceae family, were also found. From this study, it is suggested that the analgesic effect observed is not due to the terpenoids previously reported from fruit and seed extracts, but could be attributed to flavones and the hederagenin derivatives that were identified as main constituents of the hydroethanolic extract from the leaves.

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“…Some flavonoids can block the biosynthetic processes of eicosanoids, which lead to an anti-inflammatory action, because it causes inhibition of COX-2 and nitric oxide synthase (Machado et al, 2008). It is also reported that triterpenes have anti-inflammatory activity, due to inhibition of nitric oxide and prostaglandin E2 synthesis (Moraes et al, 2012). However, other disorders can lead to a decrease in PMNL migration.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological screening and acute toxicity of bark roots of Guettarda platypoda

Pina¹,

Araújo²,

Souza³

et al. 2012

Rev. bras. farmacogn.

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Due to its folk use, scientifi c reports and phytochemical screening, the purpose of this work was to study the phytochemical and the biological properties of the methanol extract and to evaluate the anti-infl ammatory activity as well as determine the acute toxicity, antitumor and cytotoxic activity of the root barks of Guettarda platypoda DC., Rubiaceae. In this analysis the presence of fl avonoids and therpenoids were identifi ed. These data and the ones in the literature indicated it as a potential antioxidant and motivated the cytotoxic analysis related with three tumoral cell strains as well as to evaluate its antitumoral activity (sarcoma 180 and Ehrlich carcinoma) in female mice. Due to the presence of esteroids and the previous study of the ethanolic extract, its anti-infl ammatory activity and toxicity were also evaluated. Absence or low toxicity in 2000 mg/kg doses was verifi ed and the attention to their phytochemical and pharmacological properties is constantly increasing.

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Triterpenes involved in the anti-inflammatory effect of ethanolic extract of Pterodon emarginatus Vogel stem bark

Cited by 29 publications

References 23 publications

Comparison of Standardized Dichloromethane with Aqueous Pterodon pubescens Benth. Fruit Extracts on Antinociceptive and Anti-Inflammatory Activity

Comparison of Standardized Dichloromethane with Aqueous Pterodon pubescens Benth. Fruit Extracts on Antinociceptive and Anti-Inflammatory Activity

Antinociceptive activity of the HPLC- and MS-standardized hydroethanolic extract of Pterodon emarginatus Vogel leaves

Pharmacological screening and acute toxicity of bark roots of Guettarda platypoda

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