Triterpenes from the flowers of Gochnatia polymorpha subsp. floccosa

Abstract

Phytochemical study of the flowers of Gochnatia polymorpha subsp. floccosa, Asteraceae, yielded eleven known triterpenes identified as lupeol, lupeyl acetate, lupeyl palmitate, taraxasterol, taraxasteryl acetate, pseudotaraxasterol, pseudotaraxasterol acetate, α-amyrin, α-amyryl palmitate, β-amyrin and β-amyryl palmitate, along with sitosterol, stigmasterol, palmitic and stearic acids. These compounds are been reported for the first time in the species. The compounds were identified by analysis of NMR spectra ( 1 H, 13 C and DEPT), GC-MS and comparison with literature data. Previous work have reported the isolation of triterpenes, diterpenes, sesquiterpenes, flavonoids, coumarins and phenolic compounds from aerial parts and roots from G. polymorpha.

Bioactivity‐guided Isolation of Cytotoxic Sesquiterpene Lactones of Gochnatia polymorpha ssp. floccosa

“…It has been used in folk medicine to treat respiratory diseases. Sesquiterpenes lactones, along with triterpenes, diterpenes, flavonoids and coumarins have been reported previously for this species (Farias et al , ; Bohlmann et al , ; Sacilotto et al , ; Moreira et al , ; Catalan et al , ; Piornedo et al , , Silva et al , ). Antiinflammatory and antispasmodic effects have been reported for the leaves and trunk of G. polymorpha (Moreira et al , ; Schlemper et al , ; Piornedo et al , ).…”

A New Sesquiterpene Lactone and Other Constituents of Moquiniastrum polymorphum subsp. floccosum (Asteraceae)

“…Analysis of HSQC and HMBC spectra revealed fifteen carbon atoms, including three typical of oxygenated carbons ( 72.5, 81.1 and 82.3), and one for a carbonyl ester group ( 179.3). These data suggested a guaianolide, similar to 11,13-dihydrozaluzanin C, previously reported for this species [9], but with an additional hydroxyl group. Analysis of correlations observed in the HSQC and HMBC spectra confirmed the guaianolide framework and the position of hydroxyl groups in C-1 and C-3.…”

Antiprotozoal activity of major constituents from the bioactive fraction of Verbesina encelioides

“…1S); pseudotaraxasterol-3β-acetate (1), benzyl 2,6-dimethoxy benzoate (2), 16-hydroxy-pseudotaraxasterol-3β-palmitate (3) and pseudotaraxasterol (4), β-sitosterol glucoside (5) and β-sitosterol galactoside (6). Identification of the isolated compounds was based on physicochemical properties, 1D and 2D spectral analysis and comparison to published data (Silva 2011;Lu 1993;Mahato 1994) (Tables 1S &2S). The presence of 8 methyl groups (7 were singlet and one was doublet) along with the HMBC correlation suggested pseudotaraxasterol skeleton in all three compounds.…”

“…The presence of an acetate group at the 3-position of 1 was evident from the HMBC correlation between the proton at 3-position at δH 4.44 ppm to the carbonyl group at δC171 ppm which in turn showed strong correlation to a methyl group at δH 2.03 ppm. Accordingly, 1 was identified as pseudotaraxasterol-3-acetate (Mahato 1994, Silva 2011.…”