A New Sesquiterpene Lactone and Other Constituents of <i>Moquiniastrum polymorphum</i> subsp. <i>floccosum</i> (Asteraceae)

Strapasson, L B; Rüdiger, André Luis; Burrow, Robert A.; Barison, Andersson; Stefanello, Maria Élida Alves

doi:10.1177/1934578x1400901102

Cited by 4 publications

(4 citation statements)

References 21 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For high-performance liquid chromatography (HPLC), methanol (HPLC grade, Panreac), trifluoroacetic acid (analytical grade, Vetec), and ultra-pure water from a Milli-Q system were used for the eluent preparation. 3,5-O-[E]-Dicaffeoylquinic acid (3,5-CQA), 4,5-O-[E]-dicaffeoylquinic acid (4,5-CQA), and 3,4-O-[E]-dicaffeoylquinic acid (3,4-CQA) were previously isolated and identified by NMR (Strapasson et al 2015) and used as authentic chemical reference compounds.…”

Section: Chemicalsmentioning

confidence: 99%

Hydroethanolic extract of Baccharis trimera promotes gastroprotection and healing of acute and chronic gastric ulcers induced by ethanol and acetic acid

Lívero

Silva

Maria-Ferreira

et al. 2016

Naunyn-Schmiedeberg's Arch Pharmacol

View full text Add to dashboard Cite

Ethanol is a psychoactive substance highly consumed around the world whose health problems include gastric lesions. Baccharis trimera is used in folk medicine for the treatment of gastrointestinal disorders. However, few studies have evaluated its biological and toxic effects. To validate the popular use of B. trimera and elucidate its possible antiulcerogenic and cytotoxic mechanisms, a hydroethanolic extract of B. trimera (HEBT) was evaluated in models of gastric lesions. Rats and mice were used to evaluate the protective and antiulcerogenic effects of HEBT on gastric lesions induced by ethanol, acetic acid, and chronic ethanol consumption. The effects of HEBT were also evaluated in a pylorus ligature model and on gastrointestinal motility. The LD50 of HEBT in mice was additionally estimated. HEBT was analyzed by nuclear magnetic resonance, and a high-performance liquid chromatography fingerprint analysis was performed. Oral HEBT administration significantly reduced the lesion area and the oxidative stress induced by acute and chronic ethanol consumption. However, HEBT did not protect against gastric wall mucus depletion and did not alter gastric secretory volume, pH, or total acidity in the pylorus ligature model. Histologically, HEBT accelerated the healing of chronic gastric ulcers in rats, reflected by contractions of the ulcer base. Flavonoids and caffeoylquinic acids were detected in HEBT, which likely contributed to the therapeutic efficacy of HEBT, preventing or reversing ethanol- and acetic acid-induced ulcers, respectively. HEBT antiulcerogenic activity may be partially attributable to the inhibition of free radical generation and subsequent prevention of lipid peroxidation. Our results indicate that HEBT has both gastroprotective and curative activity in animal models, with no toxicity.

show abstract

Section: Chemicalsmentioning

confidence: 99%

Hydroethanolic extract of Baccharis trimera promotes gastroprotection and healing of acute and chronic gastric ulcers induced by ethanol and acetic acid

Lívero

Silva

Maria-Ferreira

et al. 2016

Naunyn-Schmiedeberg's Arch Pharmacol

View full text Add to dashboard Cite

show abstract

“…Due to its good resistance to adverse conditions, with a density of 0.76 g cm³, M. polymorphum is mainly used as wood for small rural buildings and fencing. The species, however, also carries pharmacological, ornamental and environmental value (Pessatto et al 2017;Strapasson et al 2017;Corrêa et al 2018;Brandes et al 2019). For example, because of its phenotypic plasticity, it is successfully used in the restoration and rehabilitation of degraded forests (Rossatto and Kolb 2010;Ribeiro and Kolb 2016).…”

Section: Introductionmentioning

confidence: 99%

Physiological quality of Moquiniastrum polymorphum seeds processed with a general seed blower

et al. 2022

View full text Add to dashboard Cite

This study evaluates the physiological quality of Moquiniastrum polymorphum seeds, processed by a General seed blower, based on their germinability at different temperatures and on the imbibition curve, aiming to support future studies of M. polymorphum seeds processed by a General seed blower. Seeds were characterized regarding moisture, purity, germinability and thousand seed weight. The experiment was carried out in a completely randomized design (CRD). To characterize the triphasic process of germination, the imbibition curve during seed germination was modelled using 2 samples of seeds weighing 0.05 g. Physiological seed quality was assessed using a thermogradient table at 15, 20, 25, 30, 35 and 40 °C (with constant light supply) and by calculating the germination speed index (GSI), along with the time to reach 50% germination (T50) and uniformity of germination (U75-25). Each temperature treatment included 4 replications of 50 seeds each. It was found that the optimum temperature for germination was 30 °C with constant light supply, resulting in higher means of normal seedlings, GSI, T50 and U75-25. Moreover, the imbibition curve at 30 °C and constant light supply exhibited a triphasic pattern common to seed germination. In conclusion, the new findings on the germinative potential of M. polymorphum seeds processed by a General seed blower uncovered here can be applied in the methodology of future studies of M. polymorphum or used as recommendations for species of the same genus

show abstract

“…Asteraceae is a family of eudicots characterized by diverse bioactive metabolites, and the Moquiniastrum genus, which belongs to this family, is found in South America and is used in folk medicine for treating respiratory diseases, such as asthma, bronchitis, coughs, and colds. Studies revealed these plants exhibit anti-trypanosomal, antiradical, anti-inflammatory, antispasmodic, antibacterial, cytotoxic, and antioxidant activities [10][11][12][13]. This genus has already been found to contain compounds such as genkwanin, hispidulin, cirsimaritin, and chlorogenic acid derivatives.…”

Section: Introductionmentioning

confidence: 99%

Bioaffinity Fishing Procedure Using Secretory Phospholipase A2 for Screening for Bioactive Components: Modulation of Pharmacological Effect Induced by sPLA2 from Crotalus durissus terrificus by Hispidulin from Moquiniastrum floribundum

et al. 2020

View full text Add to dashboard Cite

Bioaffinity capturing of molecules allows the discovery of bioactive compounds and decreases the need for various stages in the natural compound isolation process. Despite the high selectivity of this technique, the screening and identification methodology depends on the presence of a protein to capture potential ligands. However, some proteins, such as snake secretory phospholipase A2 (sPLA2), have never been investigated using this approach. The purpose of this study was to evaluate the use of a new method for screening natural compounds using a bioaffinity-guided ultrafiltration method on Crotalus durissus terrificus sPLA2 followed by HPLC-MS to identify the compounds, and this method could be used to discover new anti-inflammatory compounds from the various organisms originating from biodiversity. Different extracts were selected to evaluate their ability to inhibit sPLA2 activity. The extracts were incubated with sPLA2 and the resulting mixture was ultrafiltrated to elute unbound components. The resulting compounds were identified by HPLC-MS. We identified hispidulin as one of the components present in the Moquiniastrum floribundum leaf and evaluated the ability of this isolated compound to neutralize the inflammatory activity of sPLA2 from Crotalus durissus terrificus.

show abstract

A New Sesquiterpene Lactone and Other Constituents of Moquiniastrum polymorphum subsp. floccosum (Asteraceae)

Cited by 4 publications

References 21 publications

Hydroethanolic extract of Baccharis trimera promotes gastroprotection and healing of acute and chronic gastric ulcers induced by ethanol and acetic acid

Hydroethanolic extract of Baccharis trimera promotes gastroprotection and healing of acute and chronic gastric ulcers induced by ethanol and acetic acid

Physiological quality of Moquiniastrum polymorphum seeds processed with a general seed blower

Bioaffinity Fishing Procedure Using Secretory Phospholipase A2 for Screening for Bioactive Components: Modulation of Pharmacological Effect Induced by sPLA2 from Crotalus durissus terrificus by Hispidulin from Moquiniastrum floribundum

Contact Info

Product

Resources

About