Triterpene saponins from the seeds of Erythrophleum fordii and their cytotoxic activities

Structure-activity relationship of triterpenoid saponins: Biological properties and commercial applicabilities

“…Or even leading to (C), in which there is another current of researchers who argue that breaking a cell membrane only by interacting with cholesterol would be a very drastic effect, with little cholesterol in a membrane to break it, and it requires additional interactions with the fatty acids present in the membrane phospholipid chain. Cell membrane rupture is related to increased saponin concentration, responsible for increased membrane permeability (FIGURE 12) [30,31] . Source: Image made by the authors adapted from [30,31] .…”

“…Cell membrane rupture is related to increased saponin concentration, responsible for increased membrane permeability (FIGURE 12) [30,31] . Source: Image made by the authors adapted from [30,31] .…”

Potent Antihyperuricemic Triterpenoids Based on Two Unprecedented Scaffolds from the Leaves of Alstonia scholaris

“…H-5 was positioned in an α-orientation by the large coupling constant ( J 5,6β = 11.6 Hz) and the co-occurrence of H-5α of natural triterpenoids. , In its ROESY (rotating frame Overhauser effect spectroscopy) spectrum in pyridine- d 5 , nuclear Overhauser effect (NOE) correlations of δ H 3.24 (H-3) with 0.76 (H-5) and 1.01 (H-23) placed 3-OH in the β-orientation. NOE correlations of δ H 1.33 (H-27) with 0.76 (H-5) and 2.88 (H-19) and of δ H 1.43 (H-27) with 1.65 (H-9) indicated the α-orientation for all of these protons.…”

“…H-5 was also assigned an α-orientation by a large coupling constant ( J 5,6β = 11.1 Hz). − In its ROESY spectrum (Figure ), the NOE correlations of δ H 0.64 (H-5) with 3.18 (H-3) and 0.94 (H-23) positioned the 3β-OH. The NOE correlations of δ H 0.88 (H-9) with 0.64 (H-5) and 10.0 (H-12), of δ H 10.0 (H-12) with 1.25 (H-27) and 5.12 (H-11), and of δ H 5.12 (H-11) with 2.19 (H-18) placed them at the same side in the α-orientation.…”

“…H-5 was positioned in an α-orientation by the large coupling constant (J 5,6β = 11.6 Hz) 18 and the co-occurrence of H-5α of natural triterpenoids. 19,20 In its ROESY (rotating frame Overhauser effect spectroscopy) spectrum in pyridine- C NMR spectral data of 2 with those of 3β,13β-dihydroxy-12,13-dihydrooleanolic acid 22 indicated that the differences in 2 were an oxygenated methine carbon, a missing methylene, and an additional aldehyde group.…”