Triterpene glycosides from Schefflera octophylla

Sung, Trần Văn; Steglich, Wölfgang; Adam, G.

doi:10.1016/0031-9422(91)83647-4

Cited by 46 publications

(28 citation statements)

References 14 publications

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“…The compounds from the PE of MCEE were identified as: 3-epi-betulinic acid (1, 10.2 mg) [19,20], betulonic acid (2, 12.5 mg) [21,22], oleanolic acid (3, 45.5 mg) [23,24], and β-amyrin acetate (4, 96.4 mg) [25,26]. The compounds from the PE of PSBT were identified as 1 (10.5 mg), 3 (47.2 mg), 4 (72.5 mg), betulinic acid (5, 46.3 mg) [19,20], erythrodiol (6, 30.2 mg) [27,28], and (3β)-olean-12-ene-3,23-diol (7, 19.6 mg) [29][30][31].…”

Section: Methodsmentioning

confidence: 99%

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Cytotoxic Activities of Extracts and Compounds from Viscum coloratum and its Transformation Products by Rhodobacter sphaeroides

Guan-e

Chen

Zhang

et al. 2008

Appl Biochem Biotechnol

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The bioassay-oriented fractionation of mistletoe crude extracts (MCEE) using 75% ethanol and culture products of mistletoe transformed by Rhodobacter sphaeroides, a photosynthetic bacterium (PSBT), revealed that the high cytotoxic activities were due to the petroleum ether extracts (PEs) and the acid-precipitated proteins from the aqueous extracts (AQs) of MCEE and PSBT. The isolated triterpenes may account for the activities of the PEs of MCEE and PSBT, respectively. Extraction of MCEE using petroleum ether led to the isolation of 3-epi-betulinic acid (1), betulonic acid (2), oleanolic acid (3), and beta-amyrin acetate (4), while petroleum ether extraction of PSBT led to the isolation of 1,3,4,betulinic acid (5), erythrodiol (6), and (3beta)-olean-12-ene-3,23-diol (7). The PE of PSBT exerted higher cytotoxicity than the PE of MCEE, which was due to the different triterpene contents of these two extracts. The cytotoxic activities of all compounds were tested, and the results revealed that compounds 1, 2, 3, 5, 6, and 7 contributed significantly to the cytotoxicities of both PEs. The AQ of the PSBT exerted almost the same cytotoxic activity and lower toxicity compared to the AQ of the MCEE. These findings indicate that mistletoe products biotransformed by R. sphaeroides could be used to treat cancers, since they have lower toxicities and higher antitumor activities compared to standard treatments.

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Section: Methodsmentioning

confidence: 99%

“…The compounds from the PE of PSBT were identified as 1 (10.5 mg), 3 (47.2 mg), 4 (72.5 mg), betulinic acid (5, 46.3 mg) [19,20], erythrodiol (6, 30.2 mg) [27,28], and (3β)-olean-12-ene-3,23-diol (7, 19.6 mg) [29][30][31]. …”

Section: Methodsmentioning

confidence: 99%

Cytotoxic Activities of Extracts and Compounds from Viscum coloratum and its Transformation Products by Rhodobacter sphaeroides

Guan-e

Chen

Zhang

et al. 2008

Appl Biochem Biotechnol

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“…The UV absorptions at 254 and 362 nm were similar to those of 3-O-methyl-3',4'-O,O-methyleneellagic acid [10] and suggested the presence of an ellagic acid skeleton. The presence of a C¼O group was revealed by a band at 1737 cm [17], and lawsonic acid (10) [18].…”

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confidence: 99%

A New Ferulic Acid Ester, a New Ellagic Acid Derivative, and Other Constituents from Pachycentria formosana: Effects on Neutrophil Pro‐Inflammatory Responses

Cho

Lee

Hwang

et al. 2011

Chemistry & Biodiversity

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A new ferulic acid ester derivative, tetracosane-1,24-diyl di[(Z)-ferulate] (1), and a new ellagic acid derivative, 3,4 : 3',4'-bis(O,O-methylene)ellagic acid (2), have been isolated from leaves and twigs of Pachycentria formosana, together with eight known compounds. Their structures were determined by in-depth spectroscopic and mass-spectrometric analyses. Among the isolated compounds, oleanolic acid (6), ursolic acid acetate (7), and 3-epibetulinic acid (9) exhibited potent inhibition (IC(50) values ≤ 21.8 μM) of O₂(-) generation by human neutrophils in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). In addition, oleanolic acid (6), 3-O-[(E)-feruloyl]ursolic acid (8), 3-epibetulinic acid (9), and lawsonic acid (10) also inhibited fMLP/CB-induced elastase release with IC(50) values ≤ 18.6 μM.

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“…The assignment of the ahydroxyl group at C-3 was performed by comparing spectral data to literature values. [14][15][16] In the NOESY spectrum, the presence of cross-peaks between H-24 and H-25 as well as H-3 indicated that the methyl group (H-24) was axial, which in turn suggested that the carboxyl group at C-4 was a-positioned. In the HMBC spectrum, the carbonyl carbon signal at d 175.1 (C-28) showed a The three isolates (1-3) were assessed for anti-inflammatory activity by examining their effects on nitric oxide (NO) and prostaglandin E 2 (PGE 2 ) by lipopolysaccharide (LPS)-induced in RAW 264.7 cells.…”

Section: Resultsmentioning

confidence: 99%