Triterpene Constituents from the Leaves of Melicope indica.

Farruque, R; Chowdhury, Rasheeduzzaman; Sohrab, Md. Hossain; Cm, Hasan; Ma, Rashid

doi:10.1002/chin.200343156

Cited by 6 publications

(3 citation statements)

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“…Steroids are widespread in plants and play an important role as components of vegetable cell walls and membranes. They have been previously been reported in many Malvaceae species, such as Sidastrum paniculatum, Wissadula periplocifolia, Sida rhombifolia, Sida galheirensis, Bakeridesia pickelli, and Herissantia crispa (Teles et al, 2015;Chaves et al, 2013;Silva et al, 2006;Costa et al, 2007;Costa et al, 2009 (Farruque et al, 2003). Triterpenes have been reported in Malvaceae species, and hopane triterpenes have recently been reported in Wissadula periplocifolia and Sidastrum paniculatum Teles et al, 2015).…”

Section: Structural Elucidation Of the Isolated Compoundsmentioning

confidence: 88%

Phytoconstituents from Sidastrum micranthum (A. St.-Hil.) Fryxell (Malvaceae) and antimicrobial activity of pheophytin a

Gomes

Teles

Pereira

et al. 2015

Braz. J. Pharm. Sci.

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Sidastrum micranthum (A. St.-Hil.) Fryxell, a member of the Malvaceae family, is called malva preta in Brazil. As this species is commonly used to treat bronchitis, cough, and asthma, better knowledge of its chemical compounds is important. The phytochemical study of its hexane extract, using chromatographic techniques, led to isolation of six compounds: the triterpene isoarborinol, a mixture of sitosterol and stigmasterol, sitosterol-3-O-β-D-glucopyranoside, pheophytin a, and 132-hydroxy-(132-S)-pheophytin a. Structural identification of these compounds was carried out using spectroscopic methods such as IR and 1D and 2D NMR (HOMOCOSY, HMQC, HMBC, and NOESY). Compounds isolated from S. micranthum were screened for their in vitro antifungal and antibacterial activity against twenty fungal and bacterial standard strains. Pheophytin a exhibited antimicrobial action against all microorganisms tested.

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Section: Structural Elucidation Of the Isolated Compoundsmentioning

confidence: 88%

Phytoconstituents from Sidastrum micranthum (A. St.-Hil.) Fryxell (Malvaceae) and antimicrobial activity of pheophytin a

Gomes

Teles

Pereira

et al. 2015

Braz. J. Pharm. Sci.

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“…The seed oil has anti-inflammatory, analgesic, anti-pyretic, anti-microbial and anti-neoplastic activity (42). Petroleum ether extract of Melicope indica afforded two unusual pentacyclic triterpenes and the ubiquitous steroids, stigmasterol and sitosterol (43). Pentacyclic tritepenes were isolated from Combretum imberbe that are novel glycosidic derivatives (hydroxyimberbic acid).…”

Section: Anti-microbial Compounds From Plantsmentioning

confidence: 99%

Therapeutic Potential of Plants as Anti‐Microbials for Drug Discovery

Samy

Gopalakrishnakone

2008

Evidence-Based Complementary and Alternative Medicine

143

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The uses of traditional medicinal plants for primary health care have steadily increased worldwide in recent years. Scientists are in search of new phytochemicals that could be developed as useful anti-microbials for treatment of infectious diseases. Currently, out of 80% of pharmaceuticals derived from plants, very few are now being used as anti-microbials. Plants are rich in a wide variety of secondary metabolites that have found anti-microbial properties. This review highlights the current status of traditional medicine, its contribution to modern medicine, recent trends in the evaluation of anti-microbials with a special emphasis upon some tribal medicine, in vitro and in vivo experimental design for screening, and therapeutic efficacy in safety and human clinical trails for commercial outlet. Many of these commercially available compounds are crude preparations administered without performing human clinical trials. Recent methods are useful to standardize the extraction for scientific investigation of new phytochemicals and anti-microbials of traditionally used plants. It is concluded that once the local ethnomedical preparations of traditional sources are scientifically evaluated before dispensing they should replace existing drugs commonly used for the therapeutic treatment of infection. This method should be put into practice for future investigations in the field of ethnopharmacology, phytochemistry, ethnobotany and other biological fields for drug discovery.

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“…202 13(18)-Neohopen-3a-ol 249 has been obtained from Melicope indica. 203 Rubia yunnanensis is a rich source of arborinane triterpenoids including rubianols A-E 250-254, rubianoside I 255 (whose parent is rubianol F 256 204 ), rubianol G 257 and rubianosides II-IV 258-260. 205 The genin of rubianoside II 258 has been named rubianol H. Rubianoside IV 260 has been isolated previously, and called rubiarboside F. 206…”

Section: The Hopane Groupmentioning

confidence: 99%