Triterpenoids

We present herein a review article of the latest developments of the biorational approaches in pest management appeared in the literature from 1997 to date. The proposed advantages of the biopesticides including their specificity, safety to non-target organisms, particularly mammals, and utilization in low, sometimes minute, amounts have led to an intensive research program by public and private institutions resulting in an avalanche of reports in attempts to discover and develop newer and safer pesticides, particularly in the past three decades. This review is divided into three main chapters, including microbial insecticides in pest control, utilization of semiochemicals, and botanical insecticides, paying particular attention to those practical approaches that are respectful to the environment.

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“…222) Recent new quassinoid isolations have been reported from Ailanthus, Brucea, Picrasma, Eurycoma, and Simaruba species. 223,224) Vol. 33, No.…”

Section: Minor Plant Insecticidesmentioning

confidence: 99%

Biorational insecticides in pest management

et al. 2008

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“…Hence, a comprehensive medicinal chemistry tools and analysis methodology are employed herein to assess the various limonin biosynthetic products. Degraded limonoids (e.g., isobenzofuranones sharing structural features with limonoids [91]) and other tetranortriterpenoids extracted from different genera and/or not belonging to the limonin biosynthetic group will not be considered and hence readers are rather directed to relevant recent reviews [15,37,[92][93][94][95][96][97][98][99][100][101].…”

Section: Medicinal Chemistry Toolsmentioning

confidence: 99%

The Chemistry and Pharmacology of Citrus Limonoids

et al. 2016

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Citrus limonoids (CLs) are a group of highly oxygenated terpenoid secondary metabolites found mostly in the seeds, fruits and peel tissues of citrus fruits such as lemons, limes, oranges, pumellos, grapefruits, bergamots, and mandarins. Represented by limonin, the aglycones and glycosides of CLs have shown to display numerous pharmacological activities including anticancer, antimicrobial, antioxidant, antidiabetic and insecticidal among others. In this review, the chemistry and pharmacology of CLs are systematically scrutinised through the use of medicinal chemistry tools and structure-activity relationship approach. Synthetic derivatives and other structurally-related limonoids from other sources are include in the analysis. With the focus on literature in the past decade, the chemical classification of CLs, their physico-chemical properties as drugs, their biosynthesis and enzymatic modifications, possible ways of enhancing their biological activities through structural modifications, their ligand efficiency metrics and systematic graphical radar plot analysis to assess their developability as drugs are among those discussed in detail.

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“…Recently, pentacyclic triterpenoids have been described to inhibit tumor progression [1]. Lantana camara L. (Verbenaceae) is one of the weeds in tropical and subtropical parts of the world [2].…”

Section: Introductionmentioning

confidence: 99%

Antitumor Activity of Lantadenes in DMBA/TPA Induced Skin Tumors in Mice: Expression of Transcription Factors

Kaur¹,

Sharma

Sharma³

et al. 2010

Am. J. Biomed. Sci.

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Various triterpenoids extracted from plants have been shown as chemopreventive agents in cancer. Lantadene A (22β-angeoloxyloxy-3-oxoolean-12-en-28-oic acid; LA) is a pentacyclic triterpenoid, isolated from a weed Lantana camara L. and semisynthetically modified to its methyl ester (Methyl22β-angeoloxyloxy-3-oxoolean-12-en-28-oate; LAM) were used for the present studies. LA and LAM were studied for its chemopreventive effect on 7, 12-dimethylbenz[a]anthracene (DMBA) followed by 12-Otetradecanoylphorbol-13-acetate (TPA) induced squamous cell carcinoma in Swiss albino mice. The skin lesions were induced by the twice-weekly topical application of DMBA (100nmol/100µl of acetone) for two weeks followed by TPA (1.7nmol/100µl of acetone) on the depilated back of mice. LA and LAM were administered orally at a dose of 50mg/kg body weight twice a week, one week before the topical application of DMBA and continued 20 weeks thereafter. Histopathology of tumors was evaluated in all treatment groups. Previous studies in authors laboratory revealed a significant decrease in incidence and average number of papillomas in mice as compared to DMBA/TPA alone at the end of study. Transcription factors; activator protein-1 (AP-1; c-jun and c-fos), Nuclear factor-kappa B (NF-κB; p65) and p53 were evaluated by using RT-PCR. A significant decrease in the mRNA expression of AP-1 (c-jun and c-fos), NF-kB (p-65) and p53 was observed in LAM and LA treated mice skin tumors. These findings were supported by histopathological studies. From the results, it can be inferred that LAM and LA possesses potential chemopreventive activity and may be linked to the expression of transcription factors.

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Triterpenoids

Cited by 36 publications

References 187 publications

Biorational insecticides in pest management

Biorational insecticides in pest management

The Chemistry and Pharmacology of Citrus Limonoids

Antitumor Activity of Lantadenes in DMBA/TPA Induced Skin Tumors in Mice: Expression of Transcription Factors

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