Triglycerides and glucose index as an insulin resistance marker in a sample of healthy adults

Toro-Huamanchumo, Carlos J.; Urrunaga-Pastor, Diego; Guarnizo-Poma, Mirella; Lázaro-Alcántara, Herbert; Paico-Palacios, Socorro; Pantoja-Torres, Betzi; Ranilla-Seguin, Vitalia Del Carmen; Benítes-Zapata, Vicente A.

doi:10.1016/j.dsx.2018.09.010

Cited by 38 publications

(33 citation statements)

References 49 publications

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“…In their study, Mazidi et al found a significant and positive correlation between HOMA‐IR and TyG index 13 . Studies have shown that TyG index is an appropriate diagnostic tool for IR, even better than HOMA‐IR in some cases 7,19,20 …”

Section: Discussionmentioning

confidence: 90%

“…HOMA‐IR is a widely used index, calculated with glucose and insulin levels and highly correlated index with the gold standard glucose clamp 3,9 . The limitations of this test are that insulin testing is a hard‐to‐reach and ubiquitous test, especially in low‐income populations, and its reproducibility and reproducibility is restricted 7 . In TyG index calculation, fasting glucose and fasting triglyceride are used, which are both low cost, easily accessible biochemistry tests 17,18 .…”

Section: Discussionmentioning

confidence: 99%

“…The gold standard method for detecting IR is glucose clamp 6,7 . Homeostatic Model Assessment (HOMA‐IR) and Quantitative Insulin Sensitivity Check Index (QUICKI) methods are alternative methods to glucose clamp using insulin and glucose levels to determine IR 8,9 .…”

Section: Introductionmentioning

confidence: 99%

“…5 The gold standard method for detecting IR is glucose clamp. 6,7 Homeostatic Model Assessment (HOMA-IR) and Quantitative Insulin Sensitivity Check Index (QUICKI) methods are alternative methods to glucose clamp using insulin and glucose levels to determine IR. 8,9 However, an insulin test is expensive and the failure to perform insulin tests in most laboratories in undeveloped countries limits the accessibility of these indices.…”

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confidence: 99%

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Triglyceride‐Glucose Index (TyG) is associated with erectile dysfunction: A cross‐sectional study

et al. 2020

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Background Erectile dysfunction (ED) is often associated with endocrine metabolic diseases such as metabolic syndrome (MetS) and diabetes mellitus (DM), in which insulin resistance (IR) plays a decisive role in pathology. Triglyceride‐glucose index (TyG), a simple, inexpensive and easily accessible IR marker, is calculated by fasting serum glucose and triglyceride values. Objectives We aimed to reveal the relationship between TyG index and ED. Materials and methods Of 152 male patients, aged between 24‐80 years, admitted to the urology outpatient clinic with complaining erectile insufficiency were evaluated. Liver function tests, complete blood count, fasting serum triglyceride, serum testosterone, fasting glucose, fasting insulin, and hemoglobinA1c (HbA1c) were analyzed. TyG index was calculated. All patients were requested to fill in the validated Turkish version of the 5‐item International Index of Erectile Function (IIEF‐5) survey. Results A total of 142 patients were included the study. ED was detected in 91 (64.1%) of the patients. BMI, fasting insulin level, fasting glucose level, IR, GGT, HDL, HbA1c, Triglyceride, TyG, DM, HT, and MetS status of the patients in ED group were statistically significantly higher compared to non‐ED group (all P < .05). It was found that the cutoff value of TyG index for ED was 8.88 (AUC = 0.739, sensitivity 67%, specificity = 68.6%). In multivariate logistic regression analysis, age (OR = 1.07, 95% CI = 1026‐1115, P = .002) and TyG index above 8.88 (OR = 3.865, 95% CI = 1686‐8859, P = .001) were found as independent predictors of ED after accounting for BMI, serum total T and IR. Conclusion TyG index might be useful in the diagnosis and follow‐up of ED.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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Triglyceride‐Glucose Index (TyG) is associated with erectile dysfunction: A cross‐sectional study

et al. 2020

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“…Not only is IR associated with CVD risk factors such as type 2 diabetes (T2D), hypertension, dyslipidemia, and obesity, but it is also an independent risk factor for CVD [ 5 ]. In this regard, Triglyceride-Glucose index (TyG-index), a product of triglyceride (TG) and fasting plasma glucose (FPG), is evaluated as a surrogate for IR [ 6 – 8 ]. Some studies have shown an association between TyG-index and incident T2D [ 9 – 12 ].…”

Section: Introductionmentioning

confidence: 99%

The impact of triglyceride-glucose index on incident cardiovascular events during 16 years of follow-up: Tehran Lipid and Glucose Study

Barzegar

Tohidi

Hasheminia

et al. 2020

Cardiovasc Diabetol

110

114

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Background To investigate whether the Triglyceride-Glucose index (TyG-index) is associated with increased risk of cardiovascular diseases (CVD)/coronary heart disease (CHD). Methods A total of 7521 Iranians aged ≥ 30 years (male = 3367) were included in the study. Multivariate Cox regression analyses (adjusted for age, gender, waist circumference, body mass index, educational level, smoking status, physical activity, family history of CVD, type 2 diabetes, hypertension, low and high density lipoprotein cholesterol, and lipid lowering drugs) were used to assess the risk of incident CVD/CHD across quintiles and for 1-standard deviation (SD) increase in the TyG-index. The cut off point for TyG-index was assessed by the minimum value of $$\sqrt {\left( {1 - sensitivity} \right)^{2} + \left( {1 - specificity} \right)^{2} }$$ 1 - s e n s i t i v i t y 2 + 1 - s p e c i f i c i t y 2 . We also examined the added value of the TyG-index in addition to the Framingham risk score when predicting CVD. Results During follow-up, 1084 cases of CVD (male = 634) were recorded. We found a significant trend of TyG-index for incident CVD/CHD in multivariate analysis (both Ps for tend ≤ 0.002). Moreover, a 1-SD increase in TyG-index was associated with significant risk of CVD/CHD in multivariate analysis [1.16 (1.07–1.25) and 1.19 (1.10–1.29), respectively]. The cut-off value of TyG-index for incident CVD was 9.03 (59.2% sensitivity and 63.2% specificity); the corresponding value of TyG-index for incident CHD was 9.03 (60.0% sensitivity and 62.8% specificity), respectively. Although no interaction was found between gender and TyG-index for CVD/CHD in multivariate analysis (both Ps for interaction > 0.085), the significant trend of TyG-index was observed only among females for incident CVD (P = 0.035). A significant interaction was found between age groups (i.e. ≥ 60 vs < 60 years) and TyG-index for CVD outcomes in the multivariate model (P-value for interaction = 0.046). Accordingly, a significant association between the TyG-index and outcomes was found only among the younger age group. Among the population aged < 60 the addition of TyG-index to the Framingham risk score (FRS) did not show improvement in the predictive ability of the FRS, using integrated discrimination improvement. Conclusion The TyG-index is significantly associated with increased risk of CVD/CHD incidence; this issue was more prominent among the younger population. However, adding TyG-index to FRS does not provide better risk prediction for CVD.

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High waist-to-hip ratio levels are associated with insulin resistance markers in normal-weight women

Benítes-Zapata

Toro-Huamanchumo

Urrunaga-Pastor

et al. 2019

Diabetes & Metabolic Syndrome: Clinical Research & Revi

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Triglycerides and glucose index as an insulin resistance marker in a sample of healthy adults

Cited by 38 publications

References 49 publications

Triglyceride‐Glucose Index (TyG) is associated with erectile dysfunction: A cross‐sectional study

Triglyceride‐Glucose Index (TyG) is associated with erectile dysfunction: A cross‐sectional study

The impact of triglyceride-glucose index on incident cardiovascular events during 16 years of follow-up: Tehran Lipid and Glucose Study

High waist-to-hip ratio levels are associated with insulin resistance markers in normal-weight women

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