Triglyceride‐Glucose Index (TyG) is associated with erectile dysfunction: A cross‐sectional study

Abstract

Background Erectile dysfunction (ED) is often associated with endocrine metabolic diseases such as metabolic syndrome (MetS) and diabetes mellitus (DM), in which insulin resistance (IR) plays a decisive role in pathology. Triglyceride‐glucose index (TyG), a simple, inexpensive and easily accessible IR marker, is calculated by fasting serum glucose and triglyceride values. Objectives We aimed to reveal the relationship between TyG index and ED. Materials and methods Of 152 male patients, aged between 24‐80 years, admitted to the urology outpatient clinic with complaining erectile insufficiency were evaluated. Liver function tests, complete blood count, fasting serum triglyceride, serum testosterone, fasting glucose, fasting insulin, and hemoglobinA1c (HbA1c) were analyzed. TyG index was calculated. All patients were requested to fill in the validated Turkish version of the 5‐item International Index of Erectile Function (IIEF‐5) survey. Results A total of 142 patients were included the study. ED was detected in 91 (64.1%) of the patients. BMI, fasting insulin level, fasting glucose level, IR, GGT, HDL, HbA1c, Triglyceride, TyG, DM, HT, and MetS status of the patients in ED group were statistically significantly higher compared to non‐ED group (all P < .05). It was found that the cutoff value of TyG index for ED was 8.88 (AUC = 0.739, sensitivity 67%, specificity = 68.6%). In multivariate logistic regression analysis, age (OR = 1.07, 95% CI = 1026‐1115, P = .002) and TyG index above 8.88 (OR = 3.865, 95% CI = 1686‐8859, P = .001) were found as independent predictors of ED after accounting for BMI, serum total T and IR. Conclusion TyG index might be useful in the diagnosis and follow‐up of ED.

Comparison of characteristics between Chinese diabetes mellitus-induced erectile dysfunction populations and non-diabetes mellitus-induced erectile dysfunction populations: A cross-sectional study

“…Thus, non-DMED patients were younger and had higher PEDT scores. In addition, studies have shown that diabetes not only causes increased FSH and atherosclerosis leading to increased TG but also leads to decreased serum TT levels and insulin resistance (higher TyG) ( 22 , 23 ), which was also verified in this study. However, research on the underlying mechanism is rarely reported, which may be the direction of our future research ( 24 ).…”

Triglycerides/Glucose Index Is Associated with Sperm Parameters and Sperm DNA Fragmentation in Primary Infertile Men: A Cross-Sectional Study

“…Several studies have shown a positive correlation between HOMA-IR and the TyG index [22] in clinical practice and, of note, some reports have shown that the TyG index is an even better diagnostic tool for IR than the HOMA score in selected patients [16,41,42]. Recently, Yilmaz et al evaluated the role of the TyG index in a cohort of 152 males with sexual dysfunction [23]; the authors found that men with erectile dysfunction had a higher TyG index and HOMA scores compared to men without ED. Moreover, they showed that a TyG index > 4.78 independently predicted ED.…”

“…A simple, inexpensive and easily accessible marker of IR has also been introduced into clinical use, i.e., the triglycerides/glucose index (TyG), which is calculated by fasting serum glucose and triglyceride values [20]. Previous studies have shown that the TyG index may be considered a good surrogate marker of IR as compared with HOMA-IR in different clinical settings, thus including men with erectile dysfunction [21][22][23].…”

A higher TyG index is related with a higher prevalence of erectile dysfunction in males between the ages 20-70 in the United States, according to a cross-sectional research

“…Since the TyG index has been presented as a marker for IR, one may speculate a link between the TyG index and ED. Currently, there is only one report on the relationship between TyG index and ED, Yilmaz ( 23 ) et al. reported a small sample study of 152 cases, concluding that TyG index may contribute to the diagnosis and follow-up of ED, then limited by the sample size, we expect to better elaborate the relationship between TyG index and ED by expanding the sample size and including more covariates.…”