Triglyceride-to-HDL cholesterol ratio

Yunke, Z; Li, Guoping; Zhenyue, C.

doi:10.1007/s00059-013-3788-0

Cited by 36 publications

(25 citation statements)

References 21 publications

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“…Our findings are consistent with the results of a hospital-based study [ 9 ], in which Yang D et al demonstrated that the TG/HDL-C ratio was not associated with the Gensini scores in Chinese CHD patients. However, in another case–control study which was also involved in Chinese CHD patients, Yunke Z et al [ 11 ] reported that the TG/HDL-C ratio can predict the severity of CHD and the incident of new-onset heart failure among in-hospital CHD patients. In Brazilians, da Luz PL et al [ 12 ] also demonstrated that the TG/HDL-C ratio was associated with the severity of CHD.…”

Section: Discussionmentioning

confidence: 99%

“…A recent cross-sectional association study [ 10 ] in a Lebanese population further revealed that the TC/HDL-C ratio ≥4 significantly predicts ≥50 % stenosis in all vessels. The ratio of TG/HDL-C was also found to be associated with the severity of CHD in two studies from Ruijin Hospital, Shanghai Jiaotong University, China [ 11 ] and Insituto do Coração, Universidade de São Paulo, Brazil [ 12 ], respectively.…”

Section: Introductionmentioning

confidence: 99%

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The apoB100/apoAI ratio is independently associated with the severity of coronary heart disease: a cross sectional study in patients undergoing coronary angiography

et al. 2015

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BackgroundLipoprotein ratios have been shown to be associated with the occurrence of coronary heart disease (CHD), but little is known about their relationships with the severity of CHD.MethodsA total of 792 angiographically defined CHD patients were enrolled following their admission. Patients were stratified into three groups based on the tertile of the Gensini scores (≤33rd percentile, 33rd to 66th percentile and ≥66th percentile) or the number of stenotic coronary branches (single-branch stenosis, double-branch stenosis and multi-branch stenosis). Demographic and biochemical data were collected and lipoprotein ratios were calculated. Logistic regression and path analysis were employed to examine the relationships between the lipoprotein ratios and the severity of CHD.ResultsThe ratios of low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C) and apolipoprotein B100 (apoB100)/apolipoprotein AI (apoAI) increased with the tertile of the Gensini scores (P < 0.05 for both). The ratios of triglyceride (TG)/HDL-C, total cholesterol (TC)/HDL-C, LDL-C/HDL-C and apoB100/apoAI increased with the number of stenotic coronary branches (P < 0.05 for all). The univariate logistic regression showed that the ratios of TC/HDL-C, LDL-C/HDL-C and apoB100/apoAI were positively associated with both the tertile of the Gensini scores and the number of stenotic vessels (P < 0.05 for all), and the ratio of TG/HDL-C was positively associated with the number of stenotic vessels (P < 0.05). In multivariate logistic analysis, only the ratio of apoB100/apoAI was independently and positively associated with the tertile of the Gensini scores (OR = 2.93, 95 % CI = 1.17-7.34, P = 0.022) and the number of stenotic vessels (OR = 3.14, 95 % CI = 1.01-6.47, P = 0.048) after adjusting for the possible confounding variables. The apoB100/apoAI ratio was also shown to be a direct mediator between the risk factors including age, BMI, HDL-C, LDL-C, apoB100 and apoAI and the severity of CHD by path analysis.ConclusionOur data indicate that the apoB100/apoAI ratio could be a useful predictor for evaluating the severity of coronary stenosis in CHD patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The apoB100/apoAI ratio is independently associated with the severity of coronary heart disease: a cross sectional study in patients undergoing coronary angiography

et al. 2015

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“…The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio has been widely used as a reliable marker of insulin resistance 8 and has a positive correlation with the incidence of type 2 diabetes and metabolic syndrome. 9 Meanwhile, TG/HDL ratio has also been demonstrated to be correlated with cardiovascular diseases, including hypertension, 10 coronary heart disease (CHD), 11 new-onset heart failure, 12 and myocardial infarction. 13 …”

Section: Introductionmentioning

confidence: 99%

<p>Triglyceride to High-Density Lipoprotein Cholesterol Ratio is an Important Determinant of Cardiovascular Risk and Poor Prognosis in Coronavirus Disease-19: A Retrospective Case Series Study</p>

Zhang¹,

Dong²,

Li³

et al. 2020

DMSO

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Background Acute myocardial injury and heart failure characterized by elevated cardiac troponin and decreased heart pump function are significant clinical features and prognostic factors of coronavirus disease-19 (COVID-19). Triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio is an indicator of insulin resistance. This study aimed to explore the association of the TG/HDL-C ratio with cardiovascular risk and prognosis in COVID-19. Methods Ninety-eight laboratory-confirmed patients with COVID-19 admitted in a tertiary teaching hospital in Wuhan, China, were enrolled in this retrospective study. Regression models were used to investigate the association between TG/HDL-C ratio with myocardial injury, heart failure, severity, and mortality in COVID-19. Results Among the 98 patients, the mean age was 63.9±1.4 years, and male sex (58, 59%) was predominant. Forty-six patients (47%) were admitted to the intensive care unit (ICU), 32 (33%) and 46 (47%) patients suffered from myocardial injury and heart failure, respectively, and 36 (37%) patients died. The TG/HDL-C ratio was increased in patients with myocardial injury, heart failure, severe illness, and fatal outcome ( P <0.05 for each). Baseline TG/HDL-C ratio significantly correlated with log transformed levels of plasma high-sensitivity cardiac troponin I (r=0.251, P =0.018), N-terminal brain natriuretic propeptide (r=0.274, P =0.008), glycated hemoglobin (r=0.239, P =0.038), and interleukin-6 (r=0.218, P =0.042). Multivariate logistic regression analysis showed that an increased TG/HDL-C ratio was independently associated with the risk of myocardial injury [odds ratio (OR)=2.73; P =0.013], heart failure (OR=2.64; P =0.019), disease severity (OR=3.01; P =0.032), and fatal outcome (OR=2.97; P =0.014). Conclusion Increased TG/HDL-C ratio was independently associated with myocardial injury, heart failure, disease severity, and mortality in patients with COVID-19, and it may be a useful marker for early identification of patients with high risk and poor outcome.

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“…47–51 The −5.85% (−10.5% to −1.15%; P = .0161) and −7.44% (−13.7% to −1.18%; P = .0211) decreases, respectively, in TC/HDL and TG/HDL reflected improved glycemic control by NFC in DM and DM/OW individuals, as well as decreased cardiovascular disease risk and heart failure risk. 50 , 52 , 53 In this study TC/HDL and TG/HDL were positively correlated with improvements in markers of insulin resistance such as LAP ( r = 0.478; and r = 0.669, respective; P < .0001 for both), FLI ( r = 0.320, P = .0038; r = 0.304, P = .0061, respectively), and number of MetS defining criteria ( r = 0.271, P = .0149; r = 0.262, P = .0190), while only TC/HDL was positively correlated with improvements in BMI ( r = 0.232, P = .038).…”

Section: Discussionmentioning

confidence: 99%

Nigella sativa and Trigonella foenum-graecum Supplemented Chapatis Safely Improve HbA1c, Body Weight, Waist Circumference, Blood Lipids, and Fatty Liver in Overweight and Diabetic Subjects: A Twelve-Week Safety and Efficacy Study

Rao¹,

Hegde²,

Pacioretty³

et al. 2020

Journal of Medicinal Food

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In 2019, * 463 million people globally had diabetes mellitus (DM), with China (25.1%), India (16.6%), and the United States (6.69%) representing nearly 50% of that total. The primary objectives of this exploratory study were to assess the safety and potential efficacy of Nigella sativa and fenugreek seed supplemented chapatis in overweight (OW) and type 2 DM subjects. Forty subjects (15/OW; 9/DM; 16/DM/OW) consumed two chapatis twice a day 6 days/week for a daily dose of 5.45 g of an N. sativa/fenugreek combination over 12 weeks with no changes in lifestyle or medications. Anthropometric, glycemic, and vascular variables were recorded at baseline and after 6 and 12 weeks. Glycated hemoglobin (HbA1c), plasma lipids, and complete metabolic profile were measured at baseline and termination. Compliance, estimated during twice-daily individual delivery of precooked chapatis, was 100%, with no significant adverse effects. At termination, body weights, body mass index, waist and hip circumferences, index of central obesity, HbA1c, fasting blood glucose, 2-h postprandial blood glucose, estimated average glucose over 12 weeks, total cholesterol (TC), non-high density lipoprotein (HDL) cholesterol, very low density lipoprotein (VLDL), and triglycerides (TG) were decreased (P < .05) over all subjects. Subjects with HbA1c ‡7.0 exhibited greater improvements in all glycemic variables than HbA1c <7.0 subjects. In addition, the decrease in HbA1c was positively correlated with decreases in (1) hepatic enzymes alkaline phosphatase (r = 0.301, P = .0067) and aspartate transaminase (r = 0.277, P = .0129), (2) systolic blood pressure (r = 0.388, P = .0004), and (3) number of diagnostic metabolic syndrome criteria exhibited per subject (r = 0.391, P = .0005), cardiovascular risk score (CRS) (r = 0.281, P = .0115), and hepatic steatosis index (HSI) (r = 0.223, P = .0467). Atherogenic and diabetogenic indexes TC/HDL, low density lipoprotein/HDL, VLDL/HDL, and TG/HDL were all decreased (P < .05). Among all subjects, improvement (P < .05) was seen in CRS (-10.7%), fatty liver index (-19.8%), lipid accumulation product (-13.8%), and HSI (-7.53%). N. sativa/fenugreek supplemented chapatis present a safe and seamless dietary modification to address cardiometabolic risk.

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Triglyceride-to-HDL cholesterol ratio

Abstract: The TG/HDL-C ratio is predictive of the severity of CHD. It could also help predict in-hospital new-onset heart failure incidents of CHD patients.

Cited by 36 publications

References 21 publications

The apoB100/apoAI ratio is independently associated with the severity of coronary heart disease: a cross sectional study in patients undergoing coronary angiography

The apoB100/apoAI ratio is independently associated with the severity of coronary heart disease: a cross sectional study in patients undergoing coronary angiography

<p>Triglyceride to High-Density Lipoprotein Cholesterol Ratio is an Important Determinant of Cardiovascular Risk and Poor Prognosis in Coronavirus Disease-19: A Retrospective Case Series Study</p>

Nigella sativa and Trigonella foenum-graecum Supplemented Chapatis Safely Improve HbA1c, Body Weight, Waist Circumference, Blood Lipids, and Fatty Liver in Overweight and Diabetic Subjects: A Twelve-Week Safety and Efficacy Study

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