The apoB100/apoAI ratio is independently associated with the severity of coronary heart disease: a cross sectional study in patients undergoing coronary angiography

Abstract

BackgroundLipoprotein ratios have been shown to be associated with the occurrence of coronary heart disease (CHD), but little is known about their relationships with the severity of CHD.MethodsA total of 792 angiographically defined CHD patients were enrolled following their admission. Patients were stratified into three groups based on the tertile of the Gensini scores (≤33rd percentile, 33rd to 66th percentile and ≥66th percentile) or the number of stenotic coronary branches (single-branch stenosis, double-branch stenosis and multi-branch stenosis). Demographic and biochemical data were collected and lipoprotein ratios were calculated. Logistic regression and path analysis were employed to examine the relationships between the lipoprotein ratios and the severity of CHD.ResultsThe ratios of low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C) and apolipoprotein B100 (apoB100)/apolipoprotein AI (apoAI) increased with the tertile of the Gensini scores (P < 0.05 for both). The ratios of triglyceride (TG)/HDL-C, total cholesterol (TC)/HDL-C, LDL-C/HDL-C and apoB100/apoAI increased with the number of stenotic coronary branches (P < 0.05 for all). The univariate logistic regression showed that the ratios of TC/HDL-C, LDL-C/HDL-C and apoB100/apoAI were positively associated with both the tertile of the Gensini scores and the number of stenotic vessels (P < 0.05 for all), and the ratio of TG/HDL-C was positively associated with the number of stenotic vessels (P < 0.05). In multivariate logistic analysis, only the ratio of apoB100/apoAI was independently and positively associated with the tertile of the Gensini scores (OR = 2.93, 95 % CI = 1.17-7.34, P = 0.022) and the number of stenotic vessels (OR = 3.14, 95 % CI = 1.01-6.47, P = 0.048) after adjusting for the possible confounding variables. The apoB100/apoAI ratio was also shown to be a direct mediator between the risk factors including age, BMI, HDL-C, LDL-C, apoB100 and apoAI and the severity of CHD by path analysis.ConclusionOur data indicate that the apoB100/apoAI ratio could be a useful predictor for evaluating the severity of coronary stenosis in CHD patients.

Discordância entre Colesterol LDL e Não-HDL e Gravidade da Doença Arterial Coronária

“…29 In two studies evaluating Gensini score and LDL-C relationship, LDL-C showed no significant difference when compared to high and low Gensini scores. 30 , 31 In our study, LDL-C was not correlated to Gensini or SYNTAX scores. Non-HDL-C was found to be higher in patients with a Gensini score of 50 or greater than patients with a Gensini score of less than 50.…”

“…29 Em dois estudos que avaliaram a relação entre escore Gensini e LDL, o LDL-C não teve diferença significativa quando comparado aos escores alto e baixo de Gensini. 30 , 31 Em nosso estudo, o nível de LDL não se correlacionou com os escores Gensini ou SYNTAX. Verificou-se que o não-HDL não era maior em pacientes com escore Gensini igual ou superior a 50 em comparação a pacientes com escore Gensini inferior a 50.…”

Hypersensitive C-reactive Protein to HDL-C Ratio Predicts the Severity of Coronary Artery Disease

“…Dyslipidemia is viewed as a necessary condition for atherosclerosis, and studies have shown that dyslipidemia may account for 50% of the attributable risk in patients with CAD. Therefore, recent studies on the correlation between lipid biomarkers and coronary heart disease have become the focus 21 . HDL-C, as a typical lipid related biomarker, plays an important protective role in the process of atherosclerosis and in ammation due to its anti-oxidant, anti-in ammatory, anti-apoptotic and anti-thrombotic properties [22][23][24] .…”

Apolipoprotein B/apolipoprotein A1 ratio and mortality among incident peritoneal dialysis patients

“…The apo B/apo A1 ratio is a typical marker for the atherogenic /antiatherogenic condition, and a higher apo B/apo A1 ratio represents progression in the atherosclerotic state. Previous studies have suggested that a high apo B/apo A1 ratio strongly correlates with pathophysiological markers of atherosclerosis defined by coronary angiography [ 8 , 20 ], and calcium scores of the coronary arteries [ 21 ], and by ultrasound techniques such as the thickness of carotid arteries [ 16 , 22 , 23 ], endothelial dysfunction [ 24 ] and existence of femoral plaques [ 25 ]. In addition, a high apo B/apo A1 ratio can also be used to predict risk of carotid plaque development [ 26 ] and major adverse cardiovascular events [ 14 , 27 – 29 ].…”

“…It is well known that, lipid-transporting apolipoprotein is an essential structural component of the lipoprotein cholesterol [ 6 ], VLDL, IDL and LDL cholesterol can each carry only a single apolipoprotein B (apo B) [ 7 ] and this characteristic can be used to reliably reflected the number of atherogenic lipoproteins in the plasma. In contrast, apo A1 has a strong association with HDL levels and accounts for approximately 60-70% of the total apolipoproteins in HDL-C, the plasma content of apo A1 represents the total of antiatherogenic particles [ 8 ]. Therefore, the ratio of apo B to apo A1 (apo B/apo A1) reflects the balance of proatherogenic and antiatherogenic particles.…”