Triglyceride-Glucose Index Simulation

Abstract

Introduction: Since its introduction as a marker of insulin resistance, the triglyceride-glucose (TyG) index has increasingly been used in biomedical literature. However, the TyG index formula seems to be calculated in two different ways, which may consequently produce some confusion regarding the normal cut-offs and cause potential errors in comparing different data. This study tries to explore this discrepancy. Materials and Methods: The TyG index was simulated for different ranges of triglyceride (TG) and fasting blood sugar (FBS). The PubMed and Scopus databases were searched for the TyG index. The results were limited to articles that have mentioned the FBS and TG values. The TyG index was recalculated and compared using the reported FBS and TG values in two different ways. Results: The simulated and reported normal cut-off values for the TyG index in the literature were roughly around 4 and 8. This discrepancy was due to different method of calculating the TyG index, and independent from factors such as age, gender and ethnicity of sampled population. Conclusions: In the TyG index formula, the division sign must be moved out of the square bracket. Otherwise, the normal range must be considered around 8. If the normal value of TyG index is reported as 4, its calculation should be referred to a corrected form of the original formula e.g. ln[FBS(mg/dl) × TG (mg/dl)]/2.

Association between Frequency of Breakfast Consumption and Insulin Resistance Using Triglyceride-Glucose Index: A Cross-Sectional Study of the Korea National Health and Nutrition Examination Survey (2016–2018)

“…Other studies have calculated the TyG index according to the following: ln(triglycerides (mg/dL) × fasting blood glucose (mg/dL))/2. The position of the division sign in the formula was inside the outer brackets when the formula was first introduced [39].…”

GCKR rs780094 Polymorphism as A Genetic Variant Involved in Physical Exercise

“…Total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein cholesterol (LDL), triacylglycerols (TAG) and glucose were determined by enzymatic spectrophotometric assay using an Architect CI8200 instrument (Abbott Laboratories, Chicago, IL, USA). The triglyceride-glucose index (TyG index) was calculated as the natural logarithm (Ln) of the product of plasma glucose and TAG according to the following formula: Ln (TAG (mg/dL) × glucose (mg/dL))/2 [32].…”

Establishing a Reference Interval for an Estimate of Peripheral Insulin Resistance in a Group of Iraqi People

“…Surrogates included HOMA-IR as (Fasting insulin [μU/mL] × FG [mg/dL]/405) [6], Mc-Auley index (Exp [2.63-0.28X ln [insulin]-0.3X ln [Tgs]) [19], and QUICKI as the reciprocal of the sum of log values of fasting insulin (μU/mL) and glucose (mg/dL) [20]. However, the modified TyG index was calculated as ln (Tgs [mg/dL] × glucose [mg/dL])/2 [12], [21] and this is the form that the online TyG index calculators apply.…”