Trigeminal trophic syndrome: successful treatment with carbamazepine

Bhushan, M.; Parry, E. J.; Telfer, Nicholas R.

doi:10.1046/j.1365-2133.1999.03133.x

Cited by 49 publications

(28 citation statements)

References 8 publications

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“…Conservative measures by local wound care with avoidance of trauma to the affected area, and controlling the secondary infections with topical or systemic antibiotics have been the most preferred methods of TTS treatment [1,2,3,5,9,10]. Transcutaneous electrical nerve stimulation to promote ulcer healing by increasing blood supply to the area was also reported [12].…”

Section: Discussionmentioning

confidence: 97%

“…Transcutaneous electrical nerve stimulation to promote ulcer healing by increasing blood supply to the area was also reported [12]. Carbamazepin was suggested to avoid self-induced trauma to the affected area, which is necessary for wound healing [2]. The use of prosthesis to cover the ulcer to avoid further manipulation is also suggested in preventing progression of the ulceration [8].…”

Section: Discussionmentioning

confidence: 99%

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Trigeminal trophic syndrome: a case with alar ulceration

Demir¹,

Aktepe

Özçukurlu

2002

European Journal of Plastic Surgery

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Trigeminal trophic syndrome is an uncommon condition characterized by chronic facial ulceration. In this syndrome, the ulceration results from selfinduced trauma caused by paresthesia resulting from damage to sensory branches of the trigeminal nerve. The differential diagnosis includes infectious, neoplastic, and immunologic processes. A patient with a nasal ulcer located on the left ala nasi extending to the adjacent cheek is presented. It was diagnosed as trigeminal trophic syndrome on the basis of clinical and histopathological findings. Treatment included resection of the ulcer followed by repair with a subcutaneous pedicled nasolabial flap.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Trigeminal trophic syndrome: a case with alar ulceration

Demir¹,

Aktepe

Özçukurlu

2002

European Journal of Plastic Surgery

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“…10 There are anecdotal reports of good outcomes with transcutaneous electrical nerve stimulation 11 and pharmacologic agents including pimozide, amitriptyline and diazepam 1 in select cases. Carbamazepine is believed to influence both the paraesthesia and the behavioural factors in this condition, 12,13 and appears to be most effective in cases in which the patient acknowledges a sense of irritation and admits to picking. Successful treatment of trigeminal trophic syndrome with negative pressure wound therapy was recently reported in a 6-year-old boy, 14 while autologous epidermal cells have been reported to induce healing in a case of trigeminal trophic syndrome with a relatively limited area of ulceration.…”

Section: Discussionmentioning

confidence: 98%

Trigeminal trophic syndrome treated with thermoplastic occlusion

Kurien

Damian

Moloney

2011

Australasian Journal of Dermatology

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A 72-year-old man with a history of thrombotic CVA causing lateral medullary infarction presented with non-healing ulcers of the right side of the face of 5 months' duration. After extensive investigations, a diagnosis of trigeminal trophic syndrome was made. The ulcers progressed relentlessly despite amitriptyline and gabapentin, and he was treated with a combination of carbamazepine and thermoplastic mask occlusion of the right side of his face. Over the next 10 weeks the shallower facial ulcers began to diminish in depth and diameter, and the deeper ulcers stopped progressing. Although the patient showed early signs of healing, he died because of complications from the CVA.

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“…Local antibiotic therapy, wound cleaning and care with Vitamin B, petrolatum gauze and hydrocolloid dressings, cervical sympathectomy, transcutaneous electrical nerve stimulation to improve blood supply and ionizing radiation have been described in the literature 2,8 . These measures yield only very limited success.…”

mentioning

confidence: 99%

“…The nasal ala and nostrils are the sites most frequently affected 1,2 . The latency period between the trigeminal nerve lesion and the onset of neurotrophic ulceration ranges from several weeks to many years 3 .…”

mentioning

confidence: 99%