Trichogram Findings in Psoriasis and Seborrheic Dermatitis Patients

Denizli, Hilal; Özden, Müge Güler; Şentürk, Nilgün; Bek, Yüksel

doi:10.5336/dermato.2017-56262

Cited by 7 publications

(4 citation statements)

References 10 publications

(14 reference statements)

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“…Finally, a number of observations have found that premature hair loss may be caused by the poor scalp health associated with either dandruff and seborrheic dermatitis,[626364] or psoriasis,[6869] indicating that the effect on the preemergent hair fiber may alter the anchoring force of the fiber with the follicle, as evidenced by an increased proportion both of catagen and telogen,[7475] and of dysplastic anagen hairs (anagen hairs devoid of hair root sheaths)[7576] in the trichogram (hair pluck).…”

Section: Role Of Oxidative Stress In Scalp Health and Agingmentioning

confidence: 99%

Scalp condition impacts hair growth and retention via oxidative stress

et al. 2018

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Conventionally, the medical focus has been either on hair loss or the condition of the scalp in terms of specific dermatological diseases. Indeed, the proximate structural arrangement of the scalp and hair leads to an interdependent relationship between the two. While protective benefits of the hair to the scalp are obvious, the role of the scalp as an incubatory environment for the preemergent hair fiber has largely been ignored. In fact, there is a wealth of observational data on specific dermatological conditions of the scalp providing evidence for the role of the scalp condition in supporting the production of healthy hair. Oxidative stress, the inability of the body to sufficiently counteract the sources of oxidation, is prevalent in many skin conditions, including normal skin aging. On the scalp, the hair appears to be impacted prior to emergence, and oxidative stress appears to play a role in premature hair loss. The scalp commensal organism, Malassezia, has been recognized to be a source of oxidative damage. Therefore, hair care products, specifically shampoos, with active Malassezia inhibitory agents, such as zinc pyrithione, tend to reduce premature hair loss, besides the known benefits in treating specific dermatologic scalp pathologies, and therefore should represent an integral part of every treatment regimen for hair loss, even in individuals not showing symptoms of scalp pathologies.

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Section: Role Of Oxidative Stress In Scalp Health and Agingmentioning

confidence: 99%

Scalp condition impacts hair growth and retention via oxidative stress

et al. 2018

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“…The protective benefits of the hair to the scalp, such as UVR screening, moisture retention, and mechanical shielding, are apparent, while the role of the scalp as an incubatory environment for the pre-emergent hair fiber is often disregarded. [41] However, there is a wealth of observational data on specific dermatological conditions of the scalp, such as dandruff and seborrheic dermatitis,[42434445464748] atopic dermatitis,[4449] and psoriasis,[50515253545556575859] providing the evidence for the role of the scalp condition in supporting the production of healthy hair. Again, oxidative stress is prevalent in all of these skin conditions,[60616263646566676869707172] just as in normal skin aging and related to the specific microbiome of the scalp and to the environmental exposures.…”

Section: Hair Fiber Quality Of Life From Scalp To Tipsmentioning

confidence: 99%

A comment on the science of hair aging

2018

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In contrast to the skin, aging of the hair has seemingly only recently found the attention of dermatological meetings, mainly promoted by the cosmetic industry for marketing purposes. In fact, basic scientists interested in the biology of hair growth and pigmentation have for some time already exposed the hair follicle as a highly accessible model with unique opportunities for the study of age-related effects. As a result, the science of hair aging focuses on two main streams of interest: the esthetic problem of aging hair and its management, in terms of age-related effects on hair color, quantity, and quality; and the biological problem of aging hair, in terms of microscopic, biochemical, and molecular changes underlying the aging process. Ultimately, the aim of hair anti-aging is to delay, lessen, or reverse the effects of aging on hair. According to the complex nature of the aging process, the treatment for lifetime scalp and hair health has to be holistic to include the multitude of contributing factors in a polyhedral and patient-specific manner. It comprises both medical treatments and hair cosmetics. Accordingly, the discovery of pharmacological targets and the development of safe and effective drugs for treatment of hair loss indicate strategies of the drug industry for maintenance of hair growth and quantity, while the hair care industry has become capable of delivering active compounds directed toward meeting the consumer demand for maintenance of hair cosmesis and quality. “Where there's life, there's hope” (Ecclesiastes 9:3-5).

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“…In fact, there is growing evidence from data involving collections and characterization of hair samples from various unhealthy scalp conditions to help establish a link between scalp condition, hair growth, and quality. [ 15 ] A number of observations have found that premature hair loss may be caused by poor scalp conditions associated with oxidative stress, such as psoriasis[ 16 17 18 ] and dandruff/seborrheic dermatitis. [ 18 19 21 ] The effect on the preemergent hair fiber may alter the anchoring force of the fiber with the follicle, as evidenced by an increased proportion both of catagen and telogen,[ 18 ] and of dysplastic anagen hairs (anagen hairs devoid of hair root sheaths) in the trichogram (hair pluck) of scalp pathologies, such as dandruff, seborrheic dermatitis, and psoriasis.…”

Section: Discussionmentioning

confidence: 99%

Efficacy, Tolerability, and Superiority of Propylene Glycol-Free, North American Witch-Hazel (Hamamelis virginiana)-Based Solution of 5% Minoxidil Sulfate for the Treatment of Female Androgenetic Alopecia

Trüeb

2023

International Journal of Trichology

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Background: Androgenetic alopecia leads to progressive hair loss in susceptible individuals if left untreated. Topical minoxidil represents an evidence-based treatment for female androgenetic alopecia, though with variable success. Aims and Objectives: Treatment of minoxidil non-responders remains challenging, as does treatment of patients with propylene glycol sensitivity or irritable scalp syndrome. Materials and Methods: Single-center, retrospective cohort of 50 female patients with androgenetic alopecia failing to respond to a minimum of 6 months of standard 5% topical minoxidil solution either once daily or b.i.d. depending on the severity of the alopecia. Patients were switched to propylene glycol-free, North American Witch Hazel (Hamamelis virginiana)-based solution of 5% minoxidil sulfate (5% minoxidil sensitive solution). Efficacy and safety of treatment were evaluated, including stereotactic global photography and epiluminiscence microscopy with digital imaging taken at baseline, at 3, and at 6 months of treatment. Results: 70% of patients showed observable clinical improvement with combined global photographic and epiluminiscence microscopic assessment with digital imaging, and 22% epiluminiscence microscopic-only improvement as evidence of treatment efficacy. The treatment was well tolerated, particularly in patients with propylene glycol sensitivity and patients with irritable scalp syndrome. Conclusions: These results suggest that propylene glycol-free, North American witch hazel (Hamamelis virginiana)-based solution of 5% minoxidil is effective and safe for treatment of female androgenetic alopecia, specifically in minoxidil non-responders and patients with propylene glycol sensitivity or irritable scalp syndrome.

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Trichogram Findings in Psoriasis and Seborrheic Dermatitis Patients

Cited by 7 publications

References 10 publications

Scalp condition impacts hair growth and retention via oxidative stress

Scalp condition impacts hair growth and retention via oxidative stress

A comment on the science of hair aging

Efficacy, Tolerability, and Superiority of Propylene Glycol-Free, North American Witch-Hazel (Hamamelis virginiana)-Based Solution of 5% Minoxidil Sulfate for the Treatment of Female Androgenetic Alopecia

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