Trichilemmal carcinoma with lymph node metastasis.

Trichilemmal Carcinoma on the Thigh: Report of a Case

“…To the best of our knowledge, only four other patients have ever been reported to have developed a TC on the thigh in Japan (5)(6)(7)(8). Table 1 reviews briefly the four previous patients and our patient with a TC on the thigh clinically.…”

“…It usually develops preferentially as a solitary tumor on the face, but occasionally or rarely appears on other areas (3,4), such as the thigh. According to the best of our knowledge, only four patients with TC on the thigh have ever been reported from Japan (5)(6)(7)(8). We describe herein a 79-year-old Japanese man with this tumor on the right thigh and review briefly the four previous and one present TC patients.…”

Trichilemmal Carcinoma Occurring in a Lesion of Solar Keratosis

“…We consider it likely in our case that bowenoid malignant transformation occurred in the interadnexal and the adnexal epithelium because of actinic damage, and developed a trichilemmal carcinoma. Most of the reported cases of trichilemmal carcinoma (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) showed lobular proliferation, V-shaped or centered on the pilar apparatus, in the superficial or marginal part of the lesion. When the tumor cells tend to keratinization (trichilemmal keratinization) while invading deeper into the dermis, the histological structure mimics that of a proliferating trichilemmal cyst (6,15).…”

“…In addition, it is frequently difficult to distinguish between trichilemmal keratinization and necrosis during usual histological examinations (5,8). Cases of the malignant trichilemmoma type with lymph node metastasis have also been reported (5)(6)(7)(8). Those features, in addition to the absence of radical differences between the two types, may lessen the significance of the strict classification of trichilemmal carcinomas.…”

“…Trichilemmal carcinoma (1) is a malignant neoplasm of hair follicles which is derived from or differentiates towards the external hair sheath. Though many cases have been reported in the Japanese literature (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16), only a few reported cases are found in the English literature (17)(18)(19)(20), and the histogenesis remains unclear. We report here a case oftrichilemmal carcinoma that evidendy occurred in a lesion of solar keratosis as judged by the clinicopathologic findings.…”