Trichilemmal Carcinoma Occurring in a Lesion of Solar Keratosis

Misago, Noriyuki; Tanaka, Tatsurou; Kohda, Hiromu

doi:10.1111/j.1346-8138.1993.tb01298.x

Cited by 17 publications

(14 citation statements)

References 12 publications

(24 reference statements)

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“…It originates from the hair follicle cells, and the differential diagnosis includes the other skin carcinomas (3)(4)(5). The common sites include the scalp, forehead and neck, which are sun-exposed areas (1).…”

Section: Discussionmentioning

confidence: 99%

Recurrent and Metastatic Trichilemmal Carcinoma of the Skin Over the Thigh: A Case Report

Sym

Park

et al. 2010

Cancer Res Treat

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I n t r o d u c t i o nTrichilemmal carcinoma (TC) is a rare malignant tumor that develops from the external root sheath of the hair follicle. It usually is found in the skin of the face or ears of elderly women on areas that are exposed to the sun, and TC generally has an indolent clinical course (1,2). This condition is usually curable after a wide excision (2). TC must be differentiated from other skin abnormalities such as squamous cell carcinoma, basal cell carcinoma, keratoacanthoma, and invasive Bowen's disease (3-5). TC is a low-grade carcinoma with a low metastatic potential (6). Surgical excision is considered to be the first choice for curative treatment (7,8), and no other reliable treatment strategies for TC have yet been established (9).We report here on a case of metastatic TC involving the skin over the thigh and this was treated with cisplatin and cyclophosphamide combination chemotherapy. C a s e R e p o r tA 63-year-old woman presented with a mass lesion in the left thigh in September 2006. The medical history and family history were unremarkable. The lesion was 5×5×4 cm in size, with irregular margins and superficial erosion. The entire lesion was removed by performing wide surgical excision and the resection margin was free of tumor. The final diagnosis was TC, and the tumor was composed of several epithelial aggregations arranged in various growth patterns, including solid, lobular and trabecular patterns (Fig. 1). In addition, the skin biopsy revealed that the specimen included neoplastic cells with abundant, clear cytoplasm, and the cells showed prominent atypia and high mitotic activity (Fig. 2).Two years later, the patient was hospitalized with swelling of the left lower leg and enlargement of the left inguinal lymph nodes. The blood pressure was 140/90 mmHg, the pulse rate was 78 bpm, the Trichilemmal carcinoma (TC) is an uncommon cutaneous neoplasm that develops from the external root sheath of the hair follicle. It is considered to be a low-grade carcinoma with low metastatic potential. Local recurrence and metastasis are rare after surgical excision. We report here on a case of metastatic TC in the skin over the thigh, and this tumor was treated with cisplatin and cyclophosphamide combination chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Recurrent and Metastatic Trichilemmal Carcinoma of the Skin Over the Thigh: A Case Report

Sym

Park

et al. 2010

Cancer Res Treat

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“…TC can develop de novo from actinically damaged skin, from chronic burn scars, in patients with repeated ionising radiation exposure and in xeroderma pigmentosum 1 8 9. Immunosuppression and human papilloma virus infection have also been implicated 10…”

Section: Discussionmentioning

confidence: 99%

Metastatic trichilemmal carcinoma in a patient with breast cancer

2016

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Trichilemmal carcinoma (TC) is described as a very rare cancer of the skin adnexa. Ninety per cent of the lesions present on the scalp. Prognostic factors in TC are limited to lymph node status and surgical margins, with no statistical significance observed for age or gender of the patient, size of tumour or locoregional recurrence. We present a 46-year-old black patient who developed TC during treatment for breast cancer. Postoperative histology of the scalp lesion excision confirmed no involved margins. At the three monthly appointment, the patient was reviewed and multiple, new scalp lesions were noted. A CT scan of the head, neck found multiple lesions on the scalp, limited to the soft tissue, not involving the outer table of the skull. There was bilateral invasion of the parotid glands. To the best of our knowledge, no syndromes or associations between breast cancer and adnexal skin tumours exist.

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“…2 It is important to differentiate trichilemmal carcinoma from other clear cell carcinomas of the skin. [2][3][4][5][6][9][10][11][12][13][14][15][16][17][18][19][20] Only 5 of the 64 cases disclosed the patients' race: 1 Caucasian 18 and 4 Asians (3 Japanese and 1 Chinese). Despite the malignant features, trichilemmal car- cinoma has a relatively benign course and does not recur after excision with clear margins.…”

Section: Discussionmentioning

confidence: 99%