Tribo-mechanical and cellular behavior of superficially modified porous titanium samples using femtosecond laser

Trueba, Paloma; Giner, Mercè; Rodríguez, Ángel; Beltrán, Ana M.; Amado, J.M.; Montoya-García, María-José; Rodríguez-Albelo, Luisa M.; Torres, Yadir

doi:10.1016/j.surfcoat.2021.127555

Cited by 13 publications

(10 citation statements)

References 47 publications

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“…Laser treatment is a contactless process, which does not pollute the implant surface, and has the advantages of wide applicability, high resolution, fast speed, good repeatability ( Vanithakumari et al, 2021 ; Chen et al, 2022 ). Femtosecond laser micromachining has been efficiently applied to supply microtopography in implant surface ( Carvalho et al, 2018 ; Stanciuc et al, 2018 ; Wang C. et al, 2019 ; Trueba et al, 2021 ). The principle of femtosecond laser is that the laser pulses travelled through air to the focusing device, which can focus the beam and position the sample.…”

Section: Strategies Of Surface Topology Modificationmentioning

confidence: 99%

Effect of microtopography on osseointegration of implantable biomaterials and its modification strategies

Zhang

Fan

Xing

et al. 2022

Front. Bioeng. Biotechnol.

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Orthopedic implants are widely used for the treatment of bone defects caused by injury, infection, tumor and congenital diseases. However, poor osseointegration and implant failures still occur frequently due to the lack of direct contact between the implant and the bone. In order to improve the biointegration of implants with the host bone, surface modification is of particular interest and requirement in the development of implant materials. Implant surfaces that mimic the inherent surface roughness and hydrophilicity of native bone have been shown to provide osteogenic cells with topographic cues to promote tissue regeneration and new bone formation. A growing number of studies have shown that cell attachment, proliferation and differentiation are sensitive to these implant surface microtopography. This review is to provide a summary of the latest science of surface modified bone implants, focusing on how surface microtopography modulates osteoblast differentiation in vitro and osseointegration in vivo, signaling pathways in the process and types of surface modifications. The aim is to systematically provide comprehensive reference information for better fabrication of orthopedic implants.

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Section: Strategies Of Surface Topology Modificationmentioning

confidence: 99%

Effect of microtopography on osseointegration of implantable biomaterials and its modification strategies

Zhang

Fan

Xing

et al. 2022

Front. Bioeng. Biotechnol.

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“…All samples were manufactured according to a methodology previously published [14,20,41,43]. Fully-dense commercially pure titanium (c.p.…”

Section: Manufacturing Of Surface Modified Porous Titanium Discs Usin...mentioning

confidence: 99%

“…Femtosecond laser irradiation was performed following the methodology presented by Rodriguez [14] and Trueba [20] and collaborators, using a Yb-doped fiber laser (Spirit 1040-4, Spectra-Physics, Santa Clara, CA, USA) with a wavelength of 1040 nm and pulses of 396 fs, at a repetition rate of f = 100 kHz. A pulse energy of Ep = 49.7 µJ (100% of nominal power) and a scanning speed of v = 960 mm/s were chosen.…”

Section: Manufacturing Of Surface Modified Porous Titanium Discs Usin...mentioning

confidence: 99%

“…The improvement of osseointegration capacity is associated with the surface roughness patterns obtained with a femtosecond laser radiation [31][32][33]35,36]. In previous works, the authors have used the Archimedean method, image analysis, Micro-CT, and scanning electron microscopy to evaluate the macro and microporosity of porous titanium samples, with and without surface modification [12,17,19,20]. However, the experimental protocols, commonly used to characterize porosity and evaluate cell activity (presence of osteoblastic cells and mineralization), are relatively long, expensive, and destructive.…”

Section: Electrical Impedance Characterizationmentioning

confidence: 99%

“…These modifications boosted superficial porosity and roughness, without any significantly affected mechanical properties of the titanium samples. Moreover, other authors have performed in vitro experiments on porous titanium substrates treated with femtosecond laser ablation, showing improved cell viability, as well as better differentiation morphology and cell adhesions, with acceptable biological response [20].…”

Section: Introductionmentioning

confidence: 99%

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Electrical Impedance of Surface Modified Porous Titanium Implants with Femtosecond Laser

et al. 2022

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The chemical composition and surface topography of titanium implants are essential to improve implant osseointegration. The present work studies a non-invasive alternative of electrical impedance spectroscopy for the characterization of the macroporosity inherent to the manufacturing process and the effect of the surface treatment with femtosecond laser of titanium discs. Osteoblasts cell culture growths on the titanium surfaces of the laser-treated discs were also studied with this method. The measurements obtained showed that the femtosecond laser treatment of the samples and cell culture produced a significant increase (around 50%) in the absolute value of the electrical impedance module, which could be characterized in a wide range of frequencies (being more relevant at 500 MHz). Results have revealed the potential of this measurement technique, in terms of advantages, in comparison to tiresome and expensive techniques, allowing semi-quantitatively relating impedance measurements to porosity content, as well as detecting the effect of surface modification, generated by laser treatment and cell culture.

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Electrical Impedance: An Effective Technique to Detect Volumetric and Surface Microstructural Variations in Materials

Navarro,

Olmo,

Torres

2024

Springer Proceedings in Materials

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Tribo-mechanical and cellular behavior of superficially modified porous titanium samples using femtosecond laser

Cited by 13 publications

References 47 publications

Effect of microtopography on osseointegration of implantable biomaterials and its modification strategies

Effect of microtopography on osseointegration of implantable biomaterials and its modification strategies

Electrical Impedance of Surface Modified Porous Titanium Implants with Femtosecond Laser

Electrical Impedance: An Effective Technique to Detect Volumetric and Surface Microstructural Variations in Materials

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