Triazine Compound as Copolymerized Antibacterial Agent in Adhesive Resins

Abstract

The aim of this study was to formulate and evaluate an experimental adhesive resin with the addition of 1,3,5-triacryloylhexahydro-1,3,5-triazine at different concentrations. Experimental adhesive resins were obtained by mixing 50% wt bisphenol A glycol dimethacrylate (BisGMA), 25% wt triethylene glycol dimethacrylate (TEGDMA), 25% wt 2-hydroxyethyl methacrylate (HEMA) and photoinitiator system. The triazine compound was added in 1, 2.5 and 5% wt to a base adhesive resin and one group remained with no triazine as control group. The experimental adhesive resins were analyzed for antibacterial activity (n=3), degree of conversion (n=3) and softening in solvent (n=3). Data distribution was evaluated by Kolmogorov-Smirnov test, paired t test, one-way ANOVA and Tukey's with a 0.05 level of significance. All groups with added triazine compound showed antibacterial activity against Streptococcus mutans (p<0.05). All groups achieved more than 70% degree of conversion, but there was no difference in this chemical property (p>0.05). The initial Knoop hardness was higher in 2.5 and 5% wt groups (p<0.05) and both groups present lower percentage variation of Knoop hardness after solvent degradation. The present study formulated an antibacterial adhesive resin with a non-releasing agent able to copolymerize with the comonomeric blend, improving the restorative material's properties.

Dental Sealant Empowered by 1,3,5-Tri Acryloyl Hexahydro-1,3,5-Triazine and α-Tricalcium Phosphate for Anti-Caries Application

“…This event possibly leads to a disruption of bacteria membrane and loss of intracellular components, as previously shown for other QACs [28]. In this study, G α-TCPTAT reduced bacterial growth on the surface of the polymerized samples compared to G CTRL , corroborating to previous analyses of TAT in resins [7][8][9]. G α-TCPTAT also reduced the number of planktonic bacteria, similar to other studies with copolymerized QAC [29].…”

“…TAT has been used to synthesize materials with better chemical and physical properties [7,8]. In the current study, the Knoop hardness and the softening in solvent, which can be related to polymers' crosslinking density, showed no differences between groups.…”

“…1,3,5-tri acryloyl hexahydro-1,3,5-triazine (TAT) is a quaternary ammonium compound (QAC) showing selective antibacterial properties against gram-positive pathogens [6], such as S. mutans. This compound has already been used in dental materials formulations, such as dentin bonding agents, composite resins and orthodontic adhesives [7][8][9]. It is a current trend to improve the therapeutics properties of dental materials by incorporating releasing or non-releasing antibacterial agents within their formulations.…”

“…The disadvantage of using an antimicrobial agent that releases over time is the loss of activity [10]. Due to its tri-functional molecule -with three methacrylate groups -TAT has the ability to copolymerize with the methacrylate resin matrix and holds more extended antibacterial activity [7]. Furthermore, materials with copolymerized TAT seem to be characterized by better physical and chemical properties [9].…”

Antibacterial, chemical and physical properties of sealants with polyhexamethylene guanidine hydrochloride

“…24 The incorporation of PHMGH into resin sealants could result in a material with antibacterial properties without affecting other properties. 2,7 The aim of this study was to evaluate the influence of PHMGH in the physico-chemical properties and antibacterial activity of an experimental resin sealant. The null hypothesis tested for the present study was that the addition of PHMGH does not influence the resin sealant properties.…”