2019
DOI: 10.1590/1807-3107bor-2019.vol33.0019
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Antibacterial, chemical and physical properties of sealants with polyhexamethylene guanidine hydrochloride

Abstract: The aim of this study was to evaluate the influence of polyhexamethylene guanidine hydrochloride (PHMGH) in the physicochemical properties and antibacterial activity of an experimental resin sealant. An experimental resin sealant was formulated with 60 wt.% of bisphenol A glycol dimethacrylate and 40 wt.% of triethylene glycol dimethacrylate with a photoinitiator/co-initiator system. PHMGH was added at 0.5 (G 0.5%), 1 (G 1%), and 2 (G 2%) wt.% and one group remained without PHMGH, used as control (G CTRL). The… Show more

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Cited by 14 publications
(20 citation statements)
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“…Furthermore, the positive charge of the OHMG derivatives enables them to act as organic bases or form salts with various inorganic or organic acids such as hydrochlorides, hydrocyrates, hydrosalicylates, hydrosuccinates, etc. Especially the properties of the branched oligohexamethylene guanidine hydrochloride salt (OHMG-HC) have been earlier established [5,6], indicating its low toxicity and antibacterial activity against various bacteria and fungi [7]. Therefore, it has been used as an active base for dental gels [8] or for sprays to treat diseases of the oral cavity [9].…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, the positive charge of the OHMG derivatives enables them to act as organic bases or form salts with various inorganic or organic acids such as hydrochlorides, hydrocyrates, hydrosalicylates, hydrosuccinates, etc. Especially the properties of the branched oligohexamethylene guanidine hydrochloride salt (OHMG-HC) have been earlier established [5,6], indicating its low toxicity and antibacterial activity against various bacteria and fungi [7]. Therefore, it has been used as an active base for dental gels [8] or for sprays to treat diseases of the oral cavity [9].…”
Section: Introductionmentioning
confidence: 99%
“…For the assessment of antibacterial property, discs of the polymerized dental resins entered into contact with an enriched broth containing S. mutans as previously performed [13,33,[40][41][42].…”
Section: Discussionmentioning
confidence: 99%
“…Figure 9 shows some chemical structures for cationic APs with sulfonium, phosphonium, or guanidinium as the cationic moiety. Besides the quaternary ammonium, cationic moieties in antimicrobial polymers could be sulfonium [139,140], guanidinium [125,128,141], or phosphonium [142,143]. Polymeric sulfonium salts exhibited high antibacterial activity against Gram−positive bacteria but were less active against Gram−negative bacteria [139].…”
Section: Asas With Apsmentioning
confidence: 99%
“…Figure 9 shows some chemical structures for cationic APs with sulfonium, phosphonium, or guanidinium as the cationic moiety. From left to right, some cationic polymers with different cationic moieties such as sulfonium [139,140], phosphonium [142], and guanidinium [141,144].…”
Section: Asas With Apsmentioning
confidence: 99%