Triangulating the pharmacological properties of thymoquinone in regulating reactive oxygen species, inflammation, and cancer: Therapeutic applications and mechanistic pathways

Phua, Caroline Yuin Hueii; Teoh, Zhi Ling; Goh, Bey Hing; Yap, Wei Hsum; Tang, Yin Quan

doi:10.1016/j.lfs.2021.120120

Cited by 12 publications

(7 citation statements)

References 64 publications

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“…TQ affects pancreatic cancer calls not by inhibiting ROS and playing an antioxidative role for cancer prevention; rather, it induces ROS production causing oxidative stress reactions leading to the activation of the JNK pathway and in turn, pancreatic cancer cell apoptosis. In gliomas and colon cancer, TQ can play a role in promoting the oxidation of cancer cells by inducing ROS production ( 80 , 81 ). The two seemingly opposite effects of TQ on the antioxidation of normal cells and pro-oxidation of cancer cells do not rule out that they are related to the specific structure of quinones ( 82 ).…”

Section: Discussionmentioning

confidence: 99%

Advances in research on the relationship between thymoquinone and pancreatic cancer

Zhao

Liu

et al. 2023

Front. Oncol.

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Pancreatic cancer has one of the worst prognoses among the most common cancers in the world. Its characteristics include a high rate of metastasis and chemotherapeutic resistance, which present major challenges to the medical community. The potential anticancer effects of thymoquinone (TQ), which is the main bioactive compound of the black seeds of the Nigella sativa plant, have recently received widespread attention for their potential use in treating pancreatic cancer. TQ can inhibit cell proliferation, promote cancer cell apoptosis, inhibit cell invasion and metastasis, enhance chemotherapeutic sensitivity, inhibit angiogenesis, and exert anti-inflammatory effects. These anticancer effects predominantly involve the nuclear factor (NF)-κB, phosphoinositide 3 kinase (PI3K)/Akt, Notch, transforming growth factor (TGF)-β, c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAPK) signaling pathways as well as the regulation of the cell cycle, matrix metallopeptidase (MMP)-9 expression, and pyruvate kinase isozyme type M2 (PKM2) activity. TQ regulates the occurrence and development of pancreatic cancer at multiple levels and through multiple targets that communicate with each other. In this review, we summarize and discuss the analogs and carriers of TQ that have been developed in recent years. Given its multilevel anticancer effects, TQ may become a new therapeutic drug for treating pancreatic cancer in the future. This review presents a brief introduction to the research that has been conducted on TQ in relation to pancreatic cancer to provide a theoretical basis for future studies on the topic.

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Section: Discussionmentioning

confidence: 99%

Advances in research on the relationship between thymoquinone and pancreatic cancer

Zhao

Liu

et al. 2023

Front. Oncol.

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“…Nigella sativa is a flowering plant that belongs to the Ranunculaceae family, native to south and southwest Asia, and is used to treat a variety of ailments such as diarrhea, asthma, headaches, cough, eczema, and more ( Ciesielska-Figlon et al, 2023 ). Thymoquinone is a bioactive constituent derived from the seeds of N. sativa and has shown significant anticancer activity in various tumors ( Phua et al, 2021 ). Thymoquinone significantly inhibits the proliferation, invasion, and metastasis of HCT116 and SW480 cells, induces cell apoptosis, and downregulates the lactic acid production, glucose uptake, and ATP levels of tumor cells ( Karim et al, 2022 ).…”

Section: Phytochemicals Targeting Signal Pathways and Transcription F...mentioning

confidence: 99%

Phytochemicals targeting glycolysis in colorectal cancer therapy: effects and mechanisms of action

Zhan,

Su,

et al. 2023

Front. Pharmacol.

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Colorectal cancer (CRC) is the third most common malignant tumor in the world, and it is prone to recurrence and metastasis during treatment. Aerobic glycolysis is one of the main characteristics of tumor cell metabolism in CRC. Tumor cells rely on glycolysis to rapidly consume glucose and to obtain more lactate and intermediate macromolecular products so as to maintain growth and proliferation. The regulation of the CRC glycolysis pathway is closely associated with several signal transduction pathways and transcription factors including phosphatidylinositol 3-kinases/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR), adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK), hypoxia-inducible factor-1 (HIF-1), myc, and p53. Targeting the glycolytic pathway has become one of the key research aspects in CRC therapy. Many phytochemicals were shown to exert anti-CRC activity by targeting the glycolytic pathway. Here, we review the effects and mechanisms of phytochemicals on CRC glycolytic pathways, providing a new method of drug development.

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“…TQ anticancer studies have revealed several mechanisms of action, such as regulation of reactive species interfering with DNA structure, modulating various potential targets and their signaling pathways as well as inducing immune system responses in vitro and in vivo. The distinctive anticancer properties of TQ are mainly due to the induction of apoptotic mechanisms, such as activation of caspases, downregulation of precancerous genes, inhibition of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), antitumor cell proliferation, hypoxia, anti-metastasis, and reduction of side effects when using traditional chemotherapeutic drugs [ 220 , 221 ]. Altering of cell cycle progression is an important step in the inhibition of cancer development and progression.…”

Section: Plant-derived Natural Products With Potential Anticancer Eff...mentioning

confidence: 99%

Plants as a Source of Anticancer Agents: From Bench to Bedside

et al. 2022

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Cancer is the second leading cause of death after cardiovascular diseases. Conventional anticancer therapies are associated with lack of selectivity and serious side effects. Cancer hallmarks are biological capabilities acquired by cancer cells during neoplastic transformation. Targeting multiple cancer hallmarks is a promising strategy to treat cancer. The diversity in chemical structure and the relatively low toxicity make plant-derived natural products a promising source for the development of new and more effective anticancer therapies that have the capacity to target multiple hallmarks in cancer. In this review, we discussed the anticancer activities of ten natural products extracted from plants. The majority of these products inhibit cancer by targeting multiple cancer hallmarks, and many of these chemicals have reached clinical applications. Studies discussed in this review provide a solid ground for researchers and physicians to design more effective combination anticancer therapies using plant-derived natural products.

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Triangulating the pharmacological properties of thymoquinone in regulating reactive oxygen species, inflammation, and cancer: Therapeutic applications and mechanistic pathways

Cited by 12 publications

References 64 publications

Advances in research on the relationship between thymoquinone and pancreatic cancer

Advances in research on the relationship between thymoquinone and pancreatic cancer

Phytochemicals targeting glycolysis in colorectal cancer therapy: effects and mechanisms of action

Plants as a Source of Anticancer Agents: From Bench to Bedside

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