Plants as a Source of Anticancer Agents: From Bench to Bedside

Talib, Wamidh H.; Daoud, Safa; Mahmod, Asma Ismail; Hamed, Reem Ali; Awajan, Dima; Abuarab, Sara Feras; Odeh, Lena Hisham; Khater, Samar; Kury, Lina T. Al

doi:10.3390/molecules27154818

Cited by 31 publications

(28 citation statements)

References 382 publications

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“…There are reports on synthetic IRAK1 inhibitors designed for therapeutic purposes against tumor or inflammatory diseases, such as JH-I-25 [ 10 ], oxfendazole (repurposed) [ 16 ], and others [ 11 ]. On the other hand, natural compounds with chemical diversity are a promising source for the development of anticancer agents [ 3 ]. However, there are few studies on the screening of IRAK1 inhibitors from natural compounds for targeted therapy of hepatocellular carcinoma.…”

Section: Discussionmentioning

confidence: 99%

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Expression of IRAK1 in Hepatocellular Carcinoma, Its Clinical Significance, and Docking Characteristics with Selected Natural Compounds

Song

2022

Current Oncology

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This study aimed to explore clinical significance of interleukin-1 receptor-associated kinase 1 (IRAK1) in the diagnosis, prognosis, and targeted therapy of hepatocellular carcinoma. A systematic analysis based on the cancer genome atlas (TCGA) indicated that IRAK1 was highly expressed in 18 cancer types (p < 0.01) and may be a pan-cancer biomarker. In hepatocellular carcinoma, the alteration rate of IRAK1 was rather high (62.4%), in which mRNA high relative to normal predominated (58.9%). Higher expression was associated with shorter overall survival (p < 0.01). IRAK1 expression correlated positively with pathology stage and tumor grade (for the latter there was only a slight trend). Interestingly, it correlated positively with TP53 mutation (p < 0.001), suggesting a possible strategy for targeting TP53 via IRAK1. Immunohistochemistry experiments confirmed a higher positive rate of IRAK1 in carcinoma than in para-carcinoma tissues (χ2 = 18.006, p < 0.001). Higher tumor grade correlated with more strongly positive staining. Molecular docking revealed cryptotanshinone, matrine, and harmine as the best hit compounds with inhibition potential for IRAK1. Our findings suggest that IRAK1 may play biologically predictive roles in hepatocellular carcinoma. The suppression of IRAK1/NF-κB signaling via inhibition of IRAK1 by the hit compounds can be a potential strategy for the targeted therapy.

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Section: Discussionmentioning

confidence: 99%

“…Further, for the purpose of targeted therapy, the discovery of therapeutic targets is crucial. Importantly, combination therapies that include the use of natural compounds targeting certain hallmarks are promising for the treatment of hepatocellular carcinoma [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Expression of IRAK1 in Hepatocellular Carcinoma, Its Clinical Significance, and Docking Characteristics with Selected Natural Compounds

Song

2022

Current Oncology

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“…According to this study, there is a marginally inverse association between breast cancer risk and each additional 100 grams/day of vegetable consumption, as the pooled relative risk (RR) was 0.97 (95% CI 0.953-0.995). The association between vegetables and breast cancer is biologically plausible because of their high contents of ber and anti-carcinogenic compounds [19][20][21][22]. Fiber may affect breast cancer risk by changing the gut microbiota, which results in lower estrogen reabsorption in the digestive system [19].…”

Section: Discussionmentioning

confidence: 99%

Association between dietary factors and breast cancer risk: A matched case-control study in Ho Chi Minh City, Vietnam

Nguyen

Phung

Nguyen

et al. 2022

Preprint

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Background The role of diet in breast cancer prevention is controversial. This study aimed to investigate the association between different dietary factors and breast cancer risk in Vietnamese women. Methods 370 newly histologically confirmed breast cancer cases and 370 controls matched by 5-year age from September 2019 to March 2020 in Ho Chi Minh City were recorded dietary intake using a validated food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (95% CI) were evaluated using conditional logistic regression and adjusted with potential confounders. Results Compared to the lowest quartile of intake, we found that the highest intake of vegetables, fruit, soybean products, coffee, and egg significantly decreased breast cancer risk, including dark green vegetables (OR 0.46, 95% CI 0.27-0.78, ptrend=0.022), legumes (OR 0.2, 95% CI 0.08-0.47, ptrend <0.001), starchy vegetables (OR 0.37, 95% CI 0.21-0.66, ptrend=0.003), other vegetables (OR 0.47, 95% CI 0.28-0.78, ptrend=0.106), fruits (OR 0.43, 95% CI 0.25-0.74, ptrend <0.001), soybean product (OR 0.45, 95% CI 0.23-0.85, ptrend=0.311), coffee (OR 0.47, 95% CI 0.23-0.95, ptrend=0.004), and egg (OR 0.4, 95% CI 0.23-0.71, ptrend=0.002). Conclusion Greater consumption of vegetables, fruit, soybean products, coffee, and egg is associated with a lower risk of breast cancer. This study provides evidence of breast cancer prevention by increasing the intake of these dietary groups.

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“…In 1880, Podwyssotzki discovered podophyllotoxin in the North American mayapple Podophyllum peltatum L. Furthermore, podophyllotoxin has also been found in Podophyllum emodi (Indian podophyllum) [ 29 ]. In 1966, etoposide was synthesized for the first time and was approved by the United States Food and Drug Administration (FDA) in 1983 as an anticancer agent [ 30 ].…”

Section: Natural Products (Nps) Against Cancermentioning

confidence: 99%

Natural Products as Anticancer Agents: Current Status and Future Perspectives

et al. 2022

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Natural products have been an invaluable and useful source of anticancer agents over the years. Several compounds have been synthesized from natural products by modifying their structures or by using naturally occurring compounds as building blocks in the synthesis of these compounds for various purposes in different fields, such as biology, medicine, and engineering. Multiple modern and costly treatments have been applied to combat cancer and limit its lethality, but the results are not significantly refreshing. Natural products, which are a significant source of new therapeutic drugs, are currently being investigated as potential cytotoxic agents and have shown a positive trend in preclinical research and have prompted numerous innovative strategies in order to combat cancer and expedite the clinical research. Natural products are becoming increasingly important for drug discovery due to their high molecular diversity and novel biofunctionality. Furthermore, natural products can provide superior efficacy and safety due to their unique molecular properties. The objective of the current review is to provide an overview of the emergence of natural products for the treatment and prevention of cancer, such as chemosensitizers, immunotherapeutics, combinatorial therapies with other anticancer drugs, novel formulations of natural products, and the molecular mechanisms underlying their anticancer properties.

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Plants as a Source of Anticancer Agents: From Bench to Bedside

Cited by 31 publications

References 382 publications

Expression of IRAK1 in Hepatocellular Carcinoma, Its Clinical Significance, and Docking Characteristics with Selected Natural Compounds

Expression of IRAK1 in Hepatocellular Carcinoma, Its Clinical Significance, and Docking Characteristics with Selected Natural Compounds

Association between dietary factors and breast cancer risk: A matched case-control study in Ho Chi Minh City, Vietnam

Natural Products as Anticancer Agents: Current Status and Future Perspectives

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