Phytochemicals targeting glycolysis in colorectal cancer therapy: effects and mechanisms of action

Zhan, Lu; Su, Fangting; Li, Qiang; Wen, Yueqiang; Wei, Feng; He, Zhelin; Chen, Xiaoyan; Yin, Xiang; Wang, Jian; Cai, Yilin; Gong, Yuxia; Chen, Yu; Ma, Xiao; Zeng, Jinhao

doi:10.3389/fphar.2023.1257450

Cited by 3 publications

(2 citation statements)

References 237 publications

(276 reference statements)

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“…The role of enhanced aerobic glycolysis in accelerating uncontrolled proliferation of cancer cells is well-established. In CRC, aerobic glycolysis not only supplies nutrients for cell proliferation but also plays a regulatory role in metastasis, angiogenesis, cell differentiation and chemotherapy resistance ( 13 - 18 ). Hence, we further explored whether LINC01977 functioned as a regulator of aerobic glycolysis; the results revealed that LINC01977 facilitated aerobic glycolysis of CRC.…”

Section: Discussionmentioning

confidence: 99%

LINC01977 promotes colorectal cancer growth and metastasis by enhancing aerobic glycolysis via the ERK/c-Myc axis

Wu,

Chen,

Wang

et al. 2024

J Gastrointest Oncol

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Background How colorectal cancer (CRC) gain the ability to growth and metastasis remains largely unknown. Findings from preceding studies have revealed the participation of long non-coding RNAs (lncRNAs) in CRC progression. However, the role of LINC01977 in CRC remains unexplored. This study aims to explore the function and underlying mechanism of LINC01977 in CRC. Methods The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets were used to analyze the expression of LINC01977 in CRC and its correlation with CRC prognosis. In our research, we explored the influence of LINC01977 on CRC progression such as cell proliferation, migration, invasion, and aerobic glycolysis, and identified its fundamental molecular mechanism using in vitro CRC cell lines and in vivo mouse xenograft models. Results LINC01977 exhibited significantly elevated expression in CRC tissues and cell lines, and its level was significantly correlated with malignant clinicopathological characteristics and negative prognosis. Furthermore, both in vivo and in vitro tests revealed LINC01977’s role in facilitating CRC cell proliferation and metastasis. LINC01977’s significant part in CRC aerobic glycolysis was also discovered. With an aim to uncover the underlying mechanism, we investigated LINC01977’s effect on c-Myc, a key gene in glycolysis. The results showed that LINC01977 regulated c-Myc stability via extracellular signal-regulated kinase (ERK)-mediated phosphorylation, and LINC01977-mediated c-Myc activated the level of vital glycolysis-related genes such as HK2, PGK1, LDHA , and GLUT1 . Rescue experiments further confirmed that LINC01977 promoted CRC proliferation, metastasis, and aerobic glycolysis via c-Myc. Conclusions This study is the first to report that LINC01977 facilitates CRC proliferation, metastasis, and aerobic glycolysis through c-Myc, suggesting its potential as a therapeutic target for CRC treatment.

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Section: Discussionmentioning

confidence: 99%

LINC01977 promotes colorectal cancer growth and metastasis by enhancing aerobic glycolysis via the ERK/c-Myc axis

Wu,

Chen,

Wang

et al. 2024

J Gastrointest Oncol

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“…The first-line chemotherapeutic agents for CRC patients include 5-FU, irinotecan (IRT), oxaliplatin (OXA), and capecitabine. 31 …”

Section: Lncrna In Tumorigenesis and Chemotherapy Resistancementioning

confidence: 99%

Research Progress of Long Non-Coding RNA in Tumor Drug Resistance: A New Paradigm

Zhang,

Wu,

Wang

et al. 2024

DDDT

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In the past few decades, chemotherapy has been one of the most effective cancer treatment options. Drug resistance is currently one of the greatest obstacles to effective cancer treatment. Even though drug resistance mechanisms have been extensively investigated, they have not been fully elucidated. Recent genome-wide investigations have revealed the existence of a substantial quantity of long non-coding RNAs (lncRNAs) transcribed from the human genome, which actively participate in numerous biological processes, such as transcription, splicing, epigenetics, the cell cycle, cell differentiation, development, pluripotency, immune microenvironment. The abnormal expression of lncRNA is considered a contributing factor to the drug resistance. Furthermore, drug resistance may be influenced by genetic and epigenetic variations, as well as individual differences in patient treatment response, attributable to polymorphisms in metabolic enzyme genes. This review focuses on the mechanism of lncRNAs resistance to target drugs in the study of tumors with high mortality, aiming to establish a theoretical foundation for targeted therapy.

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Sanqi oral solution ameliorates renal fibrosis by suppressing fibroblast activation via HIF-1α/PKM2/glycolysis pathway in chronic kidney disease

Hu,

Wang,

Zhang

et al. 2024

Journal of Ethnopharmacology

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Phytochemicals targeting glycolysis in colorectal cancer therapy: effects and mechanisms of action

Cited by 3 publications

References 237 publications

LINC01977 promotes colorectal cancer growth and metastasis by enhancing aerobic glycolysis via the ERK/c-Myc axis

LINC01977 promotes colorectal cancer growth and metastasis by enhancing aerobic glycolysis via the ERK/c-Myc axis

Research Progress of Long Non-Coding RNA in Tumor Drug Resistance: A New Paradigm

Sanqi oral solution ameliorates renal fibrosis by suppressing fibroblast activation via HIF-1α/PKM2/glycolysis pathway in chronic kidney disease

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