Triamcinolone-loaded glutaraldehyde cross-linked chitosan microspheres: Prolonged release approach for the treatment of rheumatoid arthritis

Dhanaraju, Magharla Dasaratha; Elizabeth, Sheela; Gunasekaran, Thirumurugan

doi:10.3109/10717544.2010.528069

Cited by 10 publications

(7 citation statements)

References 36 publications

(42 reference statements)

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“…Additionally, TA was encapsulated in chitosan microspheres with glutaraldehyde as the cross-linking agent to achieve a prolonged drug release. Histopathological findings as well as radiology further confirmed the effectiveness of TA encapsulated microspheres in mitigating the rat arthritic model [41]. Finally, SurModics Inc. has a delivery system capable of delivering TA on a sustained-release basis.…”

Section: Introductionmentioning

confidence: 79%

Controlled release of triamcinolone acetonide from polyurethane implantable devices: application for inhibition of inflammatory-angiogenesis

Pinto

Cunha

Oréfice

et al. 2012

J Mater Sci: Mater Med

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The purpose of this study was to develop triamcinolone acetonide-loaded polyurethane implants (TA PU implants) for the local treatment of different pathologies including arthritis, ocular and neuroinflammatory disorders. The TA PU implants were characterized by FTIR, SAXS and WAXS. The in vitro and in vivo release of TA from the PU implants was evaluated. The efficacy of TA PU implants in suppressing inflammatory-angiogenesis in a murine sponge model was demonstrated. FTIR results revealed no chemical interactions between polymer and drug. SAXS results indicated that the incorporation of the drug did not disturb the polymer morphology. WAXS showed that the crystalline nature of the TA was preserved after incorporation into the PU. The TA released from the PU implants efficiently inhibited the inflammatory-angiogenesis induced by sponge discs in an experimental animal model. Finally, TA PU implants could be used as local drug delivery systems because of their controlled delivery of TA.

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Section: Introductionmentioning

confidence: 79%

Controlled release of triamcinolone acetonide from polyurethane implantable devices: application for inhibition of inflammatory-angiogenesis

Pinto

Cunha

Oréfice

et al. 2012

J Mater Sci: Mater Med

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“…The use of natural polymers in scaffold design needs cross‐linkers to improve the scaffold stability and mechanical properties. This can be reached by the use of glutaraldehyde (GA) . To prevent the potential cytotoxicity of GA, it is possible to use an amino acid, such as glutamic acid or glycine .…”

Section: Introductionmentioning

confidence: 99%

Surface treatment with amino acids of porous collagen based scaffolds to improve cell adhesion and proliferation

et al. 2018

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The purpose of this study was to improve the biocompatibility of glutaraldehyde (GA) cross‐linked chitosan coated collagen scaffold for cartilage tissue regeneration. In order to prevent the potential toxicity of GA, we treated the designed scaffold with either glutamic acid or glycine. Amino acid treated scaffolds were characterized by scanning electron microscopy (SEM) techniques. Afterward, chondrocyte interaction with the composite scaffold was investigated assessing cell adhesion and proliferation using Hoechst staining and MTT cell proliferation assay, respectively. The SEM analyses of the scaffolds’ surface and cross‐section confirmed the adhesion of amino acids on the surface of the scaffolds. We also observed that scaffolds’ porosity was reduced due to the coverage of the pores by chitosan and amino acids, leading to low porosity. The use of amino acid improved the chondrocyte adhesion and proliferation inside the scaffolds’ pores when cells were cultured onto the chitosan‐coated collagen scaffolds. Overall, our in vitro results suggest the use of amino acid to improve the biocompatibility of natural polymer composite scaffold being crosslinked with glutaraldehyde. Such scaffold has improved mechanical properties; biocompatibility thus may be useful for tissue regeneration such as cartilage.

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“…Quality of formulation does depend on the quality of excipient [4]. The purpose of this study is to give a scope for the researchers to try and develop a formulation that is made up of just the drug and natural marine polysaccharides.…”

Section: Biological Activities and Application Of Marine Polysaccharidesmentioning

confidence: 99%

“…They are bio-compatible, non-toxic and bio-degradable and stimuli-responsive makes marine polysaccharides appropriate sources for the building of complex loading devices with a release that can be efectively controlled [4]. Table 1 shows the compilation of marine polysaccharides utilized as drug delivery carriers, and Figure 5 illustrates the mechanisms of various marine polysaccharide carriers and its method of preparation.…”

Section: As Drug Delivery Carriersmentioning

confidence: 99%

“…If anticipated to act systemically, such drugs can produce their pharmacological actions only when they come into the blood circulation from their site of application. In order to reach the blood circulation, orally administered formulation must disintegrate, deaggregate and dissolution of the drug in the aqueous luid at the absorption site must occur [4]. If the drugs are not hydrophilic in nature, the absorption process of drugs like these is usually dissolution rate-limited (Figure 1).…”

Section: Marine Polysaccharides As Multifunctional Pharmaceutical Exmentioning

confidence: 99%

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Marine Polysaccharides as Multifunctional Pharmaceutical Excipients

Thirumurugan¹,

Dhanaraju²

2017

Biological Activities and Application of Marine Polysaccharides

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This chapter is presented to depict the chance of marine polysaccharides satisfying the properties of good pharmaceutical excipients and the potential of that could be utilized as multifunctional pharmaceutical excipients in the pharmaceutical solid dosage form manufacturing as illers, diluents/vehicles, binders, glidants, binders and disintegrants, and so on. In addition, this chapter discusses the use of marine polysaccharide holding a speciic pharmacological activity in the formulation/dosage form, which is used for the same aliment/disease.

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Triamcinolone-loaded glutaraldehyde cross-linked chitosan microspheres: Prolonged release approach for the treatment of rheumatoid arthritis

Cited by 10 publications

References 36 publications

Controlled release of triamcinolone acetonide from polyurethane implantable devices: application for inhibition of inflammatory-angiogenesis

Controlled release of triamcinolone acetonide from polyurethane implantable devices: application for inhibition of inflammatory-angiogenesis

Surface treatment with amino acids of porous collagen based scaffolds to improve cell adhesion and proliferation

Marine Polysaccharides as Multifunctional Pharmaceutical Excipients

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