Triagem pré-natal para toxoplasmose e fatores associados à soropositividade de gestantes em Goiânia, Goiás

Sartori, Ana Lucia; Minamisava, Ruth; Avelino, Mariza Martins; Martins, Cleusa Alves

doi:10.1590/s0100-72032011000200007

Cited by 26 publications

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“…In addition, a study in the capital of the State of Ceará, in northeastern Brazil, found higher proportion (84%) of risky behaviors for toxoplasmosis infection among 307 pregnant adolescents [18]. These finding and the knowledge that the proportion of women susceptible to toxoplasmosis is higher among younger groups point to the high risk of acquiring the infection during pregnancy in places of high prevalence [19]. Therefore, the present study reinforces the need of prioritizing young women, particularly adolescents, in the educational policies aimed at preventing the disease.…”

Section: Discussionmentioning

confidence: 91%

Adverse Socioeconomic Conditions and Oocyst-Related Factors Are Associated with Congenital Toxoplasmosis in a Population-Based Study in Minas Gerais, Brazil

et al. 2014

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ObjectiveCongenital toxoplasmosis is a public health problem in Brazil. This study aimed to determine risk factors associated with congenital toxoplasmosis in Minas Gerais which is the second largest Brazilian State based on number of inhabitants, and its territorial extension is larger than that of France. Methods: Population-based case-control study to assess the association between congenital toxoplasmosis and maternal exposure to infection risk factors. The study included mothers/children participating in the Minas Gerais Newborn Screening Program. The cases consisted of 175 mothers of infected children, and the controls consisted of 278 mothers of children without suspected infection. The associations were assessed through binomial logistic regression with p≤0.05.ResultsThe variables associated with lower probability of toxoplasmosis were: older mother age (OR = 0.89; CI95% = 0.85–0.93), higher level of education (OR = 0.85; CI95% = 0.78–0.92), access to potable water (OR = 0.21; CI95% = 0.08–0.51), and home with flush toilet (OR = 0.18; CI95% = 0.04–078). The variables associated with higher probability of infection were: cats in the neighborhood (OR = 2.27; CI95% = 1.27–4.06), owning or visiting homes with domestic cats (OR = 1.90; CI95% = 1.09–3.31), handling the soil (OR = 2.29; CI95% = 1.32–3.96), and eating fresh meat not previously frozen (OR = 3.97; CI95% = 2.17–7.25). After stratification according region of residence (rural or urban/peri-urban), home with flush toilet and consumption of treated water were protective against the disease only in the rural stratum.ConclusionsIn Minas Gerais, congenital toxoplasmosis has been associated with poor socioeconomic conditions. Considering maternal exposure to sources of Toxoplasma gondii, the predominating risk factors were those related to the ingestion of oocysts. It is expected that these results will contribute to development of a program for prevention of congenital toxoplasmosis adapted to the reality of the population of Minas Gerais. The differences between populations living in rural and urban areas regarding the main risk factors for toxoplasmosis point to the need of considering regional specificities in planning strategies to control congenital toxoplasmosis.

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Section: Discussionmentioning

confidence: 91%

Adverse Socioeconomic Conditions and Oocyst-Related Factors Are Associated with Congenital Toxoplasmosis in a Population-Based Study in Minas Gerais, Brazil

et al. 2014

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“…De maneira geral, foi possível perceber que os maiores valores de prevalência estão entre 15 a ≥35 anos. No ano de 2013 foi encontrada associação entre a soroprevalência e o acréscimo da idade, semelhante ao encontrado em Goiânia-GO, na qual a faixa predominante foi de 20 a 30 anos, aumentando com a idade 20 . Em Porto Velho-RO, verificaram maior prevalência nos pacientes que se encontravam entre as faixas etárias de 16 a 35 anos 21 .…”

Section: -60%unclassified

Prevalência de Toxoplasma gondii em gestantes atendidas pelo Sistema Único de Saúde

2017

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“…In Brazil, seroepidemiological studies show the presence of antibodies against T. gondii in about 65% of the population (FEREZIN et al, 2013;REICHE et al, 2000;SARTORI et al, 2011). The definitive hosts in the life cycle of T. gondii are cats and other felids, and several animal species such as birds and mammals act as intermediate hosts (DUBEY, 2007).…”

Section: Introductionmentioning

confidence: 99%

Different inoculum loads of Toxoplasma gondii induce reduction of myenteric neurons of the rat colon

Ferezin

Vicentino-Vieira

Góis

et al. 2017

Rev. Bras. Parasitol. Vet.

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Toxoplasmosis, a disease caused by Toxoplasma gondii, is an important health problem, especially in immunocompromised hosts. T. gondii uses the gut wall as an infection gateway, with tropism for muscular and nervous tissues causing intestinal alterations, including some in the enteric nervous system. This study aims at investigating the colon of rats infected by T. gondii in order to understand how the amount of oocysts influences in myenteric neuronal changes. Sixty Wistar rats (Rattus norvegicus) were divided into six groups. One group remained as a control and the others received inocula of 10, 50, 100, 500 or 5,000 oocysts of T. gondii. The animals were euthanized after 30 days of infection. The total neuronal population and the nitrergic subpopulation in the colon myenteric plexus of each animal was counted. The data were statistically analyzed showing less weight gain in rats with 10, 500 and 5,000 oocysts. A decrease in the number of total neurons with 50, 100 or 5,000 oocysts and an increase in the nitrergic population with 10, 100, 500 or 5,000 oocysts were verified. These results show that neuronal alterations are more significant when the infection is induced by larger inocula and reinforces the suspicion that neuronal loss is directed at cholinergic neurons.Keywords: Enteric nervous system, myenteric plexus, ascending colon, toxoplasmosis. ResumoA toxoplasmose, doença causada pelo Toxoplasma gondii, é um importante problema de saúde, principalmente em imunocomprometidos. T. gondii utiliza a parede do intestino como porta de entrada no hospedeiro e tem tropismo pelos tecidos muscular e nervoso provocando alterações intestinais, inclusive no sistema nervoso entérico. Este estudo buscou analisar o cólon de ratos infectados por T. gondii para entender como a quantidade de oocistos influencia nas alterações neuronais mientéricas. Foram utilizados 60 ratos Wistar (Rattus norvegicus) em seis grupos. Um dos grupos permaneceu como controle e os demais receberam inóculos de 10, 50, 100, 500 ou 5.000 oocistos de T. gondii. Os animais foram submetidos a eutanásia após 30 dias de infecção. No plexo mientérico do cólon dos animais foram quantificadas a população neuronal total e a subpopulação nitrérgica. Os dados foram analisados estatisticamente demonstrando inferior ganho de peso nos ratos com 10, 500 e 5.000 oocistos. Verificamos diminuição no número de neurônios totais com inóculos de 50, 100 ou 5.000 oocistos e aumento da população nitrérgica com 10, 100, 500 ou 5000 oocistos. Estes resultados mostram que alterações neuronais são mais significativas quando a infecção é induzida por inóculos maiores e reforça a suspeita de perda neuronal direcionada a neurônios colinérgicos.Palavras-chave: Sistema nervoso entérico, plexo mientérico, cólon ascendente, toxoplasmose.

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Triagem pré-natal para toxoplasmose e fatores associados à soropositividade de gestantes em Goiânia, Goiás

Cited by 26 publications

References 0 publications

Adverse Socioeconomic Conditions and Oocyst-Related Factors Are Associated with Congenital Toxoplasmosis in a Population-Based Study in Minas Gerais, Brazil

Adverse Socioeconomic Conditions and Oocyst-Related Factors Are Associated with Congenital Toxoplasmosis in a Population-Based Study in Minas Gerais, Brazil

Prevalência de Toxoplasma gondii em gestantes atendidas pelo Sistema Único de Saúde

Different inoculum loads of Toxoplasma gondii induce reduction of myenteric neurons of the rat colon

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