2004
DOI: 10.1590/s0102-311x2004000600017
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Abstract: The high prevalence of beta thalassemia among Italians and their participation in the ethnic formation of Caxias do Sul, Rio Grande do Sul State, Brazil, and neighboring cities prompted us to investigate hemoglobinopathies in 608 blood donors at the Caxias do Sul Regional Blood Center. Despite the ethnic influence, abnormal hemoglobin levels were found in only 1.81% of the donors (0.16% Hb AC, 0.99% Hb AS, and 0.66% Hb AH), similar to the levels observed in a study on qualitative disorders conducted in the rur… Show more

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Cited by 9 publications
(2 citation statements)
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“…However, researchers recommend caution when diagnosing beta thalassemia only by the dosage of Hb A2. They point out that elevated levels can also be detected in other acquired and congenital conditions and suggest repeating the test before arriving at any diagnostic conclusion ( 7 , 29 ) . Thus, we recommend further studies to confirm these findings.…”
Section: Discussionmentioning
confidence: 99%
“…However, researchers recommend caution when diagnosing beta thalassemia only by the dosage of Hb A2. They point out that elevated levels can also be detected in other acquired and congenital conditions and suggest repeating the test before arriving at any diagnostic conclusion ( 7 , 29 ) . Thus, we recommend further studies to confirm these findings.…”
Section: Discussionmentioning
confidence: 99%
“…In countries with a high prevalence of the sickle cell trait (SCT), which is often determined by neonatal screening programs, a significant proportion of blood donors may be SCT carriers [1]. In Brazil, for example, where SCT prevalence ranges from 1.1% to 9.8% in the overall population [2], the trait is found in up to 2.48% of blood donors [3][4][5][6][7]. Because individuals with SCT are usually asymptomatic, many of them are unaware of their condition at the time of donation [1].…”
Section: Introductionmentioning
confidence: 99%