A new insight into apheresis platelet donation by sickle cell trait carriers: evidences of safety and quality

Barbosa, Suzanna Araujo Tavares; Brunetta, Denise Menezes; Filho, Sérgio Luiz Arruda Parente; Primo, Guilherme de Alencar Salazar; Santos, Franklin José Candido; Carlos, Luciana Maria de Barros; Castro, Naliele Cristina Maia de; Pro, Juan Daniel Zuñiga; Daher, Elizabeth De Francesco

doi:10.15761/hmo.1000179

Cited by 1 publication

(2 citation statements)

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“…Barbosa SAT et al have evaluated the possible eligibility of SCT donors for plateletpheresis They compared a small group of SCT donors with non‐SCT donors and they observed no increase in donor complications. The quality of the obtained products in both groups was similar 22 . Furthermore, Townsend et al compared the rate of filtration failure of SCT donors in different apheresis machines 7 .…”

Section: Discussion—conclusionmentioning

confidence: 95%

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Donors with repeated blood product discards for filtration problems, clots or hemolysis: Causes and follow‐up

Díaz Padilla,

Wiersum‐Osselton,

Ghasemi Nezjad

et al. 2024

Transfusion

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IntroductionSanquin donor medicine department is informed when donations or their components are rejected. This can occur isolated or frequently. It is undesirable because the donations cannot be used and there may be an underlying medical cause. Based on regional approaches, a uniform procedure was developed.MethodsInformation about whole blood, plasma‐ plateletpheresis donations from which one or more components were rejected for filtration time (>2 h), hemolysis or clots were extracted from blood bank information system. After rejection of two successive components or donations or total ≥3 the donor is contacted. Depending on the medical history and investigation by the family doctor, the donor carrier is re‐evaluated. We looked for the causes of the discarded products and performed a survey among blood services regarding polices with discarded products.ResultsOne or more components from 1742 of about 2.2 million successful donations (0.08%) were rejected. The highest percentage of rejection was seen in plateletpheresis (1.5%), all for clots. No underlying medical causes were found. 24 whole blood donors were found to have sickle cell trait (SCT) and were permanently deferred.The policies for follow‐up after discarded products or acceptance of SCT donors vary between the 16 blood banks. Six organizations do not follow‐up donors and seven accept SCT for blood or plasma donation.ConclusionInforming donors with repeated discarded products avoids the non‐use of donations. Causes of repeated discarded products can be found by follow‐up of donors. The results of the survey indicate a large discrepancy in policies applied worldwide.

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Section: Discussion—conclusionmentioning

confidence: 95%

“…The quality of the obtained products in both groups was similar. 22 Furthermore, Townsend et al compared the rate of filtration failure of SCT donors in different apheresis machines. 7 They found the lowest rate of filtration failure in Trima compared with Haemonetics MCS+ and Alyx (respectively, 6,4%, 15,2% and 17.8%).…”

Section: Discussion-conclusionmentioning

confidence: 99%