Trends in non-AIDS-related causes of death among adults with HIV/AIDS, Brazil, 1999 to 2010

Fazito, Erika; Vasconcelos, Ana Maria Nogales; Pereira, Maúrício Gomes; Rezende, Dilermando Fazito de

doi:10.1590/s0102-311x2013001200016

Cited by 6 publications

(2 citation statements)

References 30 publications

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“…La tendencia de la mortalidad por SIDA en Brasil aumentó hasta 1996, cuando alcanzó 9,6/100.000 habitantes (3).…”

Section: Introductionunclassified

“…Desde que Brasil adoptó una política de acceso universal y gratuito a los medicamentos antirretrovirales en el sistema de Salud Pública en 1996, fueron observados cambios en el perfil de morbilidad y mortalidad por SIDA en el país, una fuerte caída en la mortalidad por SIDA en Brasil, junto con un aumento en la supervivencia, permitiendo que las personas infectadas con VIH vivan más tiempo con el virus (3).…”

Section: Introductionunclassified

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Prevalencia del Síndrome de Inmunodeficiencia Adquirida (SIDA) en el Medio Oeste brasileño, un problema de gestión de la salud

Faria

Matsuchita

2021

Epicentro Ciencias Salud

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El SIDA es una enfermedad viral infecciosa que afecta a personas de todas las edades y en todo el mundo, así como en el Centro Oeste de Brasil. Debido a su rápida propagación, es necesario evaluar la gestión de la salud en acciones prácticas relacionando con la prevención del VIH - SIDA. A través de este estudio se observa que los datos son necesarios para una reestructuración de las políticas de salud relacionadas, ya que es evidente que la propagación (tasa de incidencia) entre años es exponencial, lo que demuestra la ineficiencia de las acciones realizadas, principalmente en los municipios que lideran las actividades junto a los pacientes, existe la necesidad de establecer una salud preventiva a través de políticas y prácticas de salud que tengan un impacto directo en la población, de manera que genere conciencia sobre la importancia de esta enfermedad, tratamiento, asistencia al portador, entre otras acciones que pueden beneficiar a las personas que viven con este síndrome.

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“…La tendencia de la mortalidad por SIDA en Brasil aumentó hasta 1996, cuando alcanzó 9,6/100.000 habitantes (3).…”

Section: Introductionunclassified

Prevalencia del Síndrome de Inmunodeficiencia Adquirida (SIDA) en el Medio Oeste brasileño, un problema de gestión de la salud

Faria

Matsuchita

2021

Epicentro Ciencias Salud

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HIV and cancer: a comparative retrospective study of Brazilian and U.S. clinical cohorts

Castilho

Luz

Shepherd

et al. 2015

Infect Agents Cancer

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BackgroundWith successful antiretroviral therapy, non-communicable diseases, including malignancies, are increasingly contributing to morbidity and mortality among HIV-infected persons. The epidemiology of AIDS-defining cancers (ADCs) and non-AIDS-defining cancers (NADCs) in HIV-infected populations in Brazil has not been well described. It is not known if cancer trends in HIV-infected populations in Brazil are similar to those of other countries where antiretroviral therapy is also widely available.MethodsWe performed a retrospective analysis of clinical cohorts at Instituto Nacional de Infectologia Evandro Chagas (INI) in Rio de Janeiro and Vanderbilt Comprehensive Care Clinic (VCCC) in Nashville from 1998 to 2010. We used Poisson regression and standardized incidence ratios (SIRs) to examine incidence trends. Clinical and demographic predictors of ADCs and NADCs were examined using Cox proportional hazards models.ResultsThis study included 2,925 patients at INI and 3,927 patients at VCCC. There were 57 ADCs at INI (65% Kaposi sarcoma), 47 at VCCC (40% Kaposi sarcoma), 45 NADCs at INI, and 82 at VCCC. From 1998 to 2004, incidence of ADCs remained statistically unchanged at both sites. From 2005 to 2010, ADC incidence decreased in both cohorts (INI incidence rate ratio per year = 0.74, p < 0.01; VCCC = 0.75, p < 0.01). Overall Kaposi sarcoma incidence was greater at INI than VCCC (3.0 vs. 1.2 cases per 1,000 person-years, p < 0.01). Incidence of NADCs remained constant throughout the study period (overall INI incidence 3.6 per 1,000 person-years and VCCC incidence 5.3 per 1,000 person-years). Compared to general populations, overall risk of NADCs was increased at both sites (INI SIR = 1.4 [95% CI 1.1-1.9] and VCCC SIR = 1.3 [1.0-1.7]). After non-melanoma skin cancers, the most frequent NADCs were anal cancer at INI (n = 7) and lung cancer at VCCC (n = 11). In multivariate models, risk of ADC was associated with male sex and immunosuppression. Risk of NADC was associated with increased age.ConclusionsIn both cohorts, ADCs have decreased over time, though incidence of KS was higher at INI than VCCC. Rates of NADCs remained constant over time at both sites.Electronic supplementary materialThe online version of this article (doi:10.1186/1750-9378-10-4) contains supplementary material, which is available to authorized users.

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Survival after cancer diagnosis in a cohort of HIV-positive individuals in Latin America

Fink

Jenkins

Castilho

et al. 2018

Infect Agents Cancer

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BackgroundThis study aimed to evaluate trends and predictors of survival after cancer diagnosis in persons living with HIV in the Caribbean, Central, and South America network for HIV epidemiology cohort.MethodsDemographic, cancer, and HIV-related data from HIV-positive adults diagnosed with cancer ≤ 1 year before or any time after HIV diagnosis from January 1, 2000-June 30, 2015 were retrospectively collected. Cancer cases were classified as AIDS-defining cancers (ADC) and non-AIDS-defining cancers (NADC). The association of mortality with cancer- and HIV-related factors was assessed using Kaplan-Meier curves and Cox proportional hazards models stratified by clinic site and cancer type.ResultsAmong 15,869 patients, 783 had an eligible cancer diagnosis; 82% were male and median age at cancer diagnosis was 39 years (interquartile range [IQR]: 32–47). Patients were from Brazil (36.5%), Argentina (19.9%), Chile (19.7%), Mexico (19.3%), and Honduras (4.6%). A total of 564 ADC and 219 NADC were diagnosed. Patients with NADC had similar survival probabilities as those with ADC at one year (81% vs. 79%) but lower survival at five years (60% vs. 69%). In the adjusted analysis, risk of mortality increased with detectable viral load (adjusted hazard ratio [aHR] = 1.63, p = 0.02), age (aHR = 1.02 per year, p = 0.002) and time between HIV and cancer diagnoses (aHR = 1.03 per year, p = 0.01).ConclusionADC remain the most frequent cancers in the region. Overall mortality was related to detectable viral load and age. Longer-term survival was lower after diagnosis of NADC than for ADC, which may be due to factors unrelated to HIV.

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Trends in non-AIDS-related causes of death among adults with HIV/AIDS, Brazil, 1999 to 2010

Cited by 6 publications

References 30 publications

Prevalencia del Síndrome de Inmunodeficiencia Adquirida (SIDA) en el Medio Oeste brasileño, un problema de gestión de la salud

Prevalencia del Síndrome de Inmunodeficiencia Adquirida (SIDA) en el Medio Oeste brasileño, un problema de gestión de la salud

HIV and cancer: a comparative retrospective study of Brazilian and U.S. clinical cohorts

Survival after cancer diagnosis in a cohort of HIV-positive individuals in Latin America

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