Treatment with low-dose cytokines reduces oxidative-mediated injury in perilesional keratinocytes from vitiligo skin

Barygina, Victoria; Becatti, Matteo; Lotti, Torello; Moretti, Silvia; Taddei, Niccolò; Fiorillo, Claudia

doi:10.1016/j.jdermsci.2015.05.003

Cited by 49 publications

(42 citation statements)

References 36 publications

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“…Previously, signs of oxidative stress were found in the blood and skin of psoriatic patients [4,5] and according to our data, anti-TNFa drug Infliximab reduces oxidative stress in Peripheral Blood Mononuclear cells (PBMC) from psoriatic patients [4]. Moreover, we recently showed that the treatment with low dose SKA (femtograms per ml) IL-4, IL-10, basic fibroblasts growth factor (bFGF) and b-endorphin (b-End) decreases oxidative stress in perilesional keratinocytes obtained from vitiligo skin [6].…”

supporting

confidence: 61%

Low dose cytokines reduce oxidative stress in primary lesional fibroblasts obtained from psoriatic patients

Barygina

Becatti

Lotti

et al. 2016

Journal of Dermatological Science

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supporting

confidence: 61%

Low dose cytokines reduce oxidative stress in primary lesional fibroblasts obtained from psoriatic patients

Barygina

Becatti

Lotti

et al. 2016

Journal of Dermatological Science

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“…Plasma total antioxidant capacity, which represents the overall antioxidant defense system, was measured using the oxygen radical absorbance capacity. 19 The production of reactive oxygen species by leukocytes (lymphocytes, monocytes, and granulocytes) was measured as previously reported. 20 Pro-and anti-inflammatory cytokines were determined by a Bio-Plex cytokine assay (Bio-Rad Laboratories Inc) according to the manufacturer's instructions.…”

Section: Laboratory Measurementsmentioning

confidence: 99%

Low-Calorie Vegetarian Versus Mediterranean Diets for Reducing Body Weight and Improving Cardiovascular Risk Profile

Sofi¹,

Dinu²,

Pagliai³

et al. 2018

Circulation

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Background: Only a few randomized dietary intervention studies that investigated the effects of lacto-ovo vegetarian diet (V d ) in clinically healthy omnivorous subjects are available. Methods: We randomly assigned to overweight omnivores with a low-to-moderate cardiovascular risk profile a low-calorie V d compared with a low-calorie Mediterranean diet (MD), each lasting 3 months, with a crossover design. The primary outcome was the difference in body weight, body mass index, and fat mass changes between the 2 groups. Secondary outcomes were differences in circulating cardiovascular disease risk parameters changes between the 2 groups. Results: One hundred eighteen subjects (mean age: 51.1 years, females: 78%) were enrolled. The total participation rate at the end of the study was 84.7%. No differences between the 2 diets in body weight were observed, as reported by similar and significant reductions obtained by both V d (−1.88 kg) and MD (−1.77 kg). Similar results were observed for body mass index and fat mass. In contrast, significant differences between the 2 interventions were obtained for low-density lipoprotein cholesterol, triglycerides, and vitamin B 12 levels. The difference between the V d and MD groups, in terms of end-of-diet values, was recorded at 9.10 mg/dL for low-density lipoprotein cholesterol ( P =0.01), 12.70 mg/dL for triglycerides ( P <0.01), and 32.32 pg/mL for vitamin B 12 ( P <0.01). Finally, no significant difference was found between V d and MD interventions in oxidative stress markers and inflammatory cytokines, except for interleukin-17, which improved only in the MD group. Forty-six participants during the V d period and 35 during the MD period reached the target values for ≥1 cardiovascular risk factor. Conclusions: Both V d and MD were effective in reducing body weight, body mass index, and fat mass, with no significant differences between them. However, V d was more effective in reducing low-density lipoprotein cholesterol levels, whereas MD led to a greater reduction in triglyceride levels. Clinical Trial Registration: URL: https://www.clinicaltrials.gov . Unique identifier: NCT02641834.

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“…Starting from these preliminary data, Barygina et al (23) planned and conducted the previously synthetically described basic research preclinical study, in order to evaluate the effects of low dose SKA IL-4, IL-10, b-FGF, and β-endorphin in the modulation of intracellular and extracellular oxidative stress and on the proliferation of human perilesional keratinocytes collected from skin samples obtained from skin lesion biopsies of vitiligo patients.…”

Section: Resultsmentioning

confidence: 99%

Skin as a Psychoneuroendocrine Immunology Microcosm: The New Frontier of Low Dose Therapy With Cytokines and Growth Factors in the Systemic Treatment of Chronic Autoimmune Inflammatory Diseases in Dermatology

Lotti

Rivkina

Fioranelli

2016

Jentashapir J Health Res

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In recent years, the central role of signaling molecules, such as hormones, cytokines and growth factors, has become evident in both physiological and pathological processes; these signaling molecules are the main regulating effectors of whole body biological functions, in accordance with the guiding principle of psychoneuroendocrine immunology (PNEI). Low dose medicine (LDM) represents an innovative medical approach in which the latest evidence in the fields of molecular biology, PNEI and nano-concentration pharmacology are merged. LDM suggests the use of low-doses of activated biological molecules in order to manage PNEI homeostasis, and this approach represents a new opportunity for the development of therapeutic strategies based on immune balancing interventions. Scientific evidence regarding the efficacy and safety of the LDM approach in the treatment of psoriasis vulgaris, and positive preliminary data regarding the oral administration of low dose activated cytokines for vitiligo and atopic dermatitis treatment, support the LDM-based therapeutic approach for many dermatological diseases.Keywords: Psycho-Neuro-Endocrine-Immunology, Low Dose Medicine, Signaling Molecules, Sequential Kinetic Activation, Psoriasis Vulgaris, Dermatologic Diseases ContextIn recent years, a unified vision of the biological functions of the body has been theorized, in accordance with the guiding principles of psychoneuroendocrine immunology (PNEI) (1-4). The PNEI approach represents a paradigm shift from a strictly biomedical view of health and disease to an interdisciplinary view. The main unifying PNEI element is identified in the bi-directional crosstalk (5) between the psychoneuroendocrine systems and the immune system, which is mediated by a complex network of signaling (messenger) molecules (cytokines, hormones, growth factors, neuropeptides) that are the vehicles for the biological information necessary for the complex and efficient regulation of cellular responses to stimuli.The signaling molecules play a decisive role in determining a person's state of health or disease, and it is compelling to consider diseases as expressions of the change in concentrations (both in excess or in defect) of these substances. In order to test the hypothesis that messenger molecules can be used for therapeutic purposes, research in the medical world is increasingly directed toward the study of the messenger molecules, which determine the fate of many pathological conditions in a positive (healing) or negative (disease) way.The multi-system axes, such as the gut-brain-axis and the skin-gut-axis, are controlled and managed by a continuous information exchange driven by cytokines, neuropeptides, neuro-hormones and other signaling molecules, in order to maintain PNEI homeostasis.In summary, altered cross-talk caused by the imbalance between specific signaling molecules is a fundamental requisite for the onset of inflammatory, allergic and autoimmune diseases (6, 7). Preserving and/or restoring the physiological signaling, based on messe...

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Treatment with low-dose cytokines reduces oxidative-mediated injury in perilesional keratinocytes from vitiligo skin

Cited by 49 publications

References 36 publications

Low dose cytokines reduce oxidative stress in primary lesional fibroblasts obtained from psoriatic patients

Low dose cytokines reduce oxidative stress in primary lesional fibroblasts obtained from psoriatic patients

Low-Calorie Vegetarian Versus Mediterranean Diets for Reducing Body Weight and Improving Cardiovascular Risk Profile

Skin as a Psychoneuroendocrine Immunology Microcosm: The New Frontier of Low Dose Therapy With Cytokines and Growth Factors in the Systemic Treatment of Chronic Autoimmune Inflammatory Diseases in Dermatology

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