Treatment Outcome of Tuberculosis Under Directly Observed Treatment Short Course (Dots) in Patients Presenting at Chest Tb Hospital, Amritsar

Verma, Vishal; Singh, Jagdeepak; Chand, Nirmal; Khalsa, J.S.

doi:10.1378/chest.128.4.2824

Cited by 30 publications

(13 citation statements)

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“…While the influence of sex has been questioned[19], we continue to document a reduced median age of death for women with CF. Women with CF are more likely to be underweight than their male counterparts [20] and poor nutrition is linked to poor prognosis[21].…”

Section: Discussionmentioning

confidence: 85%

Rate of improvement of CF life expectancy exceeds that of general population—Observational death registration study

Hurley

McKeever

Prayle

et al. 2014

Journal of Cystic Fibrosis

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BackgroundIt is unclear why cystic fibrosis (CF) survival has improved. We wished to quantify increases in CF median age of death in the context of general population survival improvement.MethodDeath registration data analysis (US, England & Wales (E&W)—1972–2009).ResultsCF median age of death is higher in US than E&W and greater for males, opposite to that of death from all causes. CF median age of death has increased by 0.543 life years per year (E&W, US combined (95% confidence interval 0.506, 0.582)). The difference in median age at death between those dying from all causes and CF decreased in both territories. CF median age of death for males is greater than for females in both territories. This gap has not narrowed.ConclusionThe median age of death of people with CF is improving more rapidly than that of the general population in US and E&W.

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Section: Discussionmentioning

confidence: 85%

Rate of improvement of CF life expectancy exceeds that of general population—Observational death registration study

Hurley

McKeever

Prayle

et al. 2014

Journal of Cystic Fibrosis

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“…14 Verma et el in their study to determine the treatment outcome of 150 tuberculosis cases under DOTS presenting at chest and TB hospital, Amritsar reported the cure rate of 91% for Category I (NSP) patients. 15 A five year follow up of Revised National Tuberculosis Control Programme of India at Lucknow showed the outcome results of 208 registered patients as: treatment success (cured + treatment completed) 89.9%, default 5.3%, death 4.3% and treatment failure 0.4%. 16 According to RNTCP status report, treatment outcome of new smear positive cases for the year 2009 in Punjab was observed as: cure 85.7%, treatment completed 1.9%, died 4.5%, failure 2.2%, defaulted 4.0% and transfer out 1.7%.…”

Section: Discussionmentioning

confidence: 99%

Study on the adverse effects affecting treatment outcome in smear positive tuberculosis patients under DOTS in Amritsar city

Nagpal¹,

Devgun²,

Kalra³

et al. 2018

Int J Community Med Public Health

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Background: The world adopts DOTS strategy for TB control thought the national TB control programs in different countries and is making good progress. Despite the positive therapeutic effects, studies have shown that utilization of multidrug regimens can cause undesirable adverse drug reactions (ADRs) of varying degrees of severity, such as hepatotoxicity, gastrointestinal disorders, allergic reactions, arthralgia, neurological disorders and non-adherence to treatment as well. Methods: The study was conducted on new smear positive patients registered under DOTS in two Treatment Units (TUs) present in Amritsar city. The prevalence of various adverse effects like gastro-intestinal, hepato-biliary, visual disturbances, musculoskeletal, skin and appendages, peripheral nervous system, etc was recorded and their effect on the outcome was observed. Data management and analysis was done by using Microsoft excel and SPSS version 17.00. Results: Out of 250 patients, 149 (59.6%) were males and 101(40.4%) were females. Out of the total 250 cases, adverse effects were present in 44.4% cases. Most common adverse effects observed were gastrointestinal in 63.9% followed by fever and chills in 28.8% of cases. Conclusions: On statistical analysis, it was observed that the absence of adverse effects was significantly associated with the favourable outcome (p<0.001).

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“…The combined effect of E2 on infection and inflammation was correlated with increased pulmonary exacerbations in female CF patients in high estrogen states (estrous mid-cycle) [21]. The CF gender gap tends to diminish with age, most likely related to decreased estrogen production as patients live longer and enter the menopause but also as a result of improved physiotherapy, more aggressive antibiotics and advanced care after lung transplant [36]. However, in spite of improved and aggressive therapies, females with CF still scored worse than age-matched CF males on quality of life studies [37], and they show more acute lung exacerbations [38].…”

Section: Discussionmentioning

confidence: 99%

Non-Genomic Estrogen Regulation of Ion Transport and Airway Surface Liquid Dynamics in Cystic Fibrosis Bronchial Epithelium

et al. 2013

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Male cystic fibrosis (CF) patients survive longer than females and lung exacerbations in CF females vary during the estrous cycle. Estrogen has been reported to reduce the height of the airway surface liquid (ASL) in female CF bronchial epithelium. Here we investigated the effect of 17β-estradiol on the airway surface liquid height and ion transport in normal (NuLi-1) and CF (CuFi-1) bronchial epithelial monolayers. Live cell imaging using confocal microscopy revealed that airway surface liquid height was significantly higher in the non-CF cells compared to the CF cells. 17β-estradiol (0.1–10 nM) reduced the airway surface liquid height in non-CF and CF cells after 30 min treatment. Treatment with the nuclear-impeded Estrogen Dendrimer Conjugate mimicked the effect of free estrogen by reducing significantly the airway surface liquid height in CF and non-CF cells. Inhibition of chloride transport or basolateral potassium recycling decreased the airway surface liquid height and 17β-estradiol had no additive effect in the presence of these ion transporter inhibitors. 17β-estradiol decreased bumetanide-sensitive transepithelial short-circuit current in non-CF cells and prevented the forskolin-induced increase in ASL height. 17β-estradiol stimulated an amiloride-sensitive transepithelial current and increased ouabain-sensitive basolateral short-circuit current in CF cells. 17β-estradiol increased PKCδ activity in CF and non-CF cells. These results demonstrate that estrogen dehydrates CF and non-CF ASL, and these responses to 17β-estradiol are non-genomic rather than involving the classical nuclear estrogen receptor pathway. 17β-estradiol acts on the airway surface liquid by inhibiting cAMP-mediated chloride secretion in non-CF cells and increasing sodium absorption via the stimulation of PKCδ, ENaC and the Na+/K+ATPase in CF cells.

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Treatment Outcome of Tuberculosis Under Directly Observed Treatment Short Course (Dots) in Patients Presenting at Chest Tb Hospital, Amritsar

Cited by 30 publications

References 0 publications

Rate of improvement of CF life expectancy exceeds that of general population—Observational death registration study

Rate of improvement of CF life expectancy exceeds that of general population—Observational death registration study

Study on the adverse effects affecting treatment outcome in smear positive tuberculosis patients under DOTS in Amritsar city

Non-Genomic Estrogen Regulation of Ion Transport and Airway Surface Liquid Dynamics in Cystic Fibrosis Bronchial Epithelium

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