Treatment of Typhoid Fever by Intravenous Injections of Polyvalent Sensitized Typhoid Vaccine Sediment

The Protective Action of Dysentery Bacteriophage in Experimental Infections in Mice

“…In our experiments most deaths in the experimental animals occurred within 48 hours after infection, thus leaving little possibility of immune reactions being responsible for the protective action of dysentery-phage. Gay and Chickering (1916) suggested that the protein shock reaction is responsible for the protective action of such protein preparations. In our experiments we used both culture media proteins and heatinactivated dysentery-phage (65 C for 60 minutes) as controls.…”

Focal Infection. The Lane Medical Lectures.

“…There is now no doubt that the diplococcus also called by other observers micrococcus rheumaticus and streptococcus rheumaticus, isolated from the blood and joint fluids, throat and endocardial nodes of patients suffering from rheumatic fever by Poynton and Paine (14) confirmed by Beattie (15), Walker and Ryffel (16) and finally and conclusively by Rosenow (8), is the true infectious cause of the disease. 48 ACUTE DISEASES 49 With a knowledge of the possibility of transmutation in form, cultural characteristics and coincident variation in specific pathogenicity, virulency and tissue affinity, we may now understand the conflicting results of animal inoculation with undifferentiated strains of streptococci as reported by many workers. It is a well known fact that virulent strains of streptococci, when injected intravenously into animals, may produce acute arthritis, usually with such violent tissue reaction that suppuration occurs.…”

“…The phenomena aroused by a proper intravenous dosage consist of a chill followed by high fever, great general discomfort, usually a relatively slow pulse rate, leukocytosis sometimes of a high degree, not infrequently preceded by an immediate leukopenia. Gay and Chickering (49) have used the protein, non-toxic remnant of the typhoid bacillus by intravenous injection in the treatment of typhoid fever. The characteristic phenomena noted above resulted.…”