Treatment of the Guillain-Barre Syndrome

Heller, Grant L.

doi:10.1001/archneur.1963.00460020079006

Cited by 32 publications

(2 citation statements)

References 33 publications

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“…The association of this syndrome with a variety of disorders, particularly viral infections, would favour the concept that the pathological lesion seen within the nerve tissue itself is due to an immunological process. The favourable response to steroids in some patients (Heller and DeJong, 1963) and mercaptopurine (Palmer, 1965) in others would favour this concept.…”

Section: Discussionmentioning

confidence: 99%

Guillain-Barre syndrome associated with typhoid fever.

Chanmugam¹,

Waniganetti²

1969

BMJ

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Section: Discussionmentioning

confidence: 99%

Guillain-Barre syndrome associated with typhoid fever.

Chanmugam¹,

Waniganetti²

1969

BMJ

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Section: Discussionmentioning

confidence: 99%

Zieve's syndrome and porphyrinuria in an alcoholic.

Gitlin¹

1969

BMJ

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Treatment of acute inflammatory polyneuropathy

1981

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Most patients with acute inflammatory polyneuropathy (AIP) recover spontaneously, but the time course of the illness is unpredictable so that the results of treatment are difficult to assess. Three decades of retrospective reports of steroid treatment fail to demonstrate any striking beneficial effect. In a randomized trial of prednisolone, starting dose 60 mg daily, 21 treated patients improved more slowly than 19 untreated patients. By contrast, in rats immunized with bovine nerve root myelin, prednisolone at 10 mg/kg reduced the severity and duration of experimental allergic neuritis (EAN), the putative animal model for AIP. This discrepancy might reflect the greater difficulty of clinical as opposed to animal therapeutic trials or indicate that EAN is not the appropriate model for the human disease. Immunosuppressive drugs, plasmapheresis and other agents have also been employed, but their efficacy cannot be decided from the available case report. The role of similar agents in chronic progressive and relapsing inflammatory neuropathy cannot yet be resolved, but in some patients steroids do appear to be valuable.

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Treatment of the Guillain-Barre Syndrome

Cited by 32 publications

References 33 publications

Guillain-Barre syndrome associated with typhoid fever.

Guillain-Barre syndrome associated with typhoid fever.

Zieve's syndrome and porphyrinuria in an alcoholic.

Treatment of acute inflammatory polyneuropathy

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