Zieve's syndrome and porphyrinuria in an alcoholic.

Gitlin, Norman

doi:10.1136/bmj.1.5636.96

Cited by 8 publications

(2 citation statements)

References 17 publications

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“…Similar cases11 12 continued to emerge along with frequent observation of porphyrinuria,13 increased plasma viscosity with severe myalgias14 and retinal injury,15 all of which proved reversible with alcohol abstinence. Hyperlipidaemia was implicated as a potential causal factor of intracranial haemorrhage in a few instances of Zieve's 16…”

Section: Discussionmentioning

confidence: 89%

Hyperbilirubinaemia and haemolytic anaemia in acute alcoholic hepatitis: there's oil in them thar veins

et al. 2014

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A Caucasian woman in her late 30s was evaluated after a period of binge drinking and found to have hyperbilirubinaemia for which she was referred for consideration of cholecystectomy. After exclusion of other possibilities, Zieve's syndrome was diagnosed. This is a condition of hyperbilirubinaemia, Coombs’ negative haemolytic anaemia and hyperlipidaemia associated with alcoholism. Abstinence from alcohol remains the only known effective treatment, and appreciation of the entity can prevent unnecessary biliary procedures. The patient improved with supportive measures and was discharged in stable condition.

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Section: Discussionmentioning

confidence: 89%

Hyperbilirubinaemia and haemolytic anaemia in acute alcoholic hepatitis: there's oil in them thar veins

et al. 2014

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“…32 Yet case reports of Zieve's syndrome continued to be published from around the world. [33][34][35][36][37][38][39] Some authors point out that the hepatic steatosis may actually mask underlying alcoholic hepatitis, 34,38 whereas others emphasized related complications such as porphyrinuria, 40 fatality following hepatic angiography, 41 intracranial hemorrhage, 42 severe myalgias 43 and retinal injury. 44 Zieve's original concern that the patient with this syndrome might be mistakenly thought to require surgical intervention, was rediscovered 40 years after the original warning.…”

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confidence: 99%

True, true … but are they related?

Reuben

2006

Hepatology

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Ver�nderungen in den Membranlipiden der Erythrocyten bei �thanolinduzierter Hyperlipid�mie (Zieve-Syndrom)

1976

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In 11 patients with alcohol-induced hyperlipemia, of whom 6 showed a Zieve Syndrome increased phospholipids, triglycerides and total cholesterol were found in the red cells stromal. The gasliquid chromatographic analysis of the phospholipid fatty acids showed increased contents of saturated and monounsaturated fatty acids C 16-C 18 smaller contents of longchain highly unsaturated fatty acids. The changes in the fatty acid pattern mainly occurred in patients with Zieve Syndrome and could be important for the mechanism of the hemolytic anemia. Theses findings could be in connexion with vitamin E deficiency.

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Zieve's syndrome and porphyrinuria in an alcoholic.

Cited by 8 publications

References 17 publications

Hyperbilirubinaemia and haemolytic anaemia in acute alcoholic hepatitis: there's oil in them thar veins

Hyperbilirubinaemia and haemolytic anaemia in acute alcoholic hepatitis: there's oil in them thar veins

True, true … but are they related?

Ver�nderungen in den Membranlipiden der Erythrocyten bei �thanolinduzierter Hyperlipid�mie (Zieve-Syndrom)

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