Treatment of acute inflammatory polyneuropathy

Hughes, Richard; Kadlubowski, M.; Hufschmidt, Andreas

doi:10.1002/ana.410090718

Cited by 64 publications

(9 citation statements)

References 58 publications

(21 reference statements)

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“…There is no specific therapy for the Guillain-BarrC syndrome and the treatment is based on good nursing, physiotherapy and prevention of respiratory failure as well as of circulatory and thrombo-embolic events. The value of ACTH or corticosteroid therapy is still an open question (Sigwald & Nouailhat 1970, Arnason 1975, Swick & McQuillen 1976, Hughes et al 1981. The effect of plasmapheresis remains to be examined more closely (Asbury et al 1980, Hughes et aI.…”

Section: Discussionmentioning

confidence: 99%

A clinical study of the Guillain-Barré syndrome

Andersson

Sidén

2009

Acta Neurologica Scandinavica

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60 consecutive patients (age 15‐77 years) with the Guillain‐Barré syndrome were studied. 37 subjects had an antecedent infection. Onset occurred with motor and/or sensory limb symptoms in 56 cases; 4 subjects experienced onsets with pain, diplopia or bladder disturbances. The motor symptoms reached a maximum within 42 days in all cases, 87% within < 20 days. All patients had limb‐muscle weakness at the symptomatic maximum; 50% exhibited cranial‐nerve affections and 10 subjects had respiratory insufficiency. Signs of a remission appeared within 60 days after onset in all cases surviving the maximal phase, 81% within < 40 days. The CSF protein concentration was elevated (0.6‐7.8 g/l) in 95% of the patients; an increased mononuclear cell count (6‐60 × 106/l) occurred in 27% of cases. Electrophysiological abnormalities were detected in 42 out of 43 examined cases. Totally there were 4 deaths, all caused by cardiac or thrombo‐embolic events. Surviving patients had restitutions without functionally significant sequelae within less than 6 months after onset in 73% of cases; all but 2 of the remaining patients recovered within 18 months. The degree of muscle weakness at maximum was the predominant prognostic factor.

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Section: Discussionmentioning

confidence: 99%

A clinical study of the Guillain-Barré syndrome

Andersson

Sidén

2009

Acta Neurologica Scandinavica

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“…Sebagian besar penderita waktu masuk rumah sakit dengan derajat kelumpuhan 3 (14,15,16), pada peneliti yaitu sebanyak 28 penderita (73,68%).…”

Section: Diskusiunclassified

Manifestasi Klinis Dan Laboratoris Penderita Sindroma Guillain Barre Di Ruang Perawatan Anak Rsu Dr. Saiful Anwar Malang

Muid

2013

JKB

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Guillain Barre Syndrome is one of the leading diseases from Acute Flaccid Paralysis after the decrease in poliomyelitis. In Guillain Barre Syndrome, the motoric muscles becomes weak and it could also attack the respiratory muscle which is life threatening to patients. The objective of this study is to report Guillain Barre Syndrome cases from June 1999 until June 2005 based on the clinical manifestation and laboratory in children care unit of dr. Saiful Anwar hospital. In this research there were 38 Guillain Barre Syndrome cases which were diagnosed using the Gilroy and Meyer criteria. 22 patients (57,9%) were male, 16 patients (42,1%) were female. 18 patients (43,36%) were below 5 years of age, 13 patients (34,21%) were between 5 to 10 years of age and 7 patients (18,42%) were between the age of 10 to15 years. The most common infection that precedes was upper respiratory infenction which amounts to 32 cases (84,21%). The latent phase between 8 to 14 days were 11 patients (28,94%) and 15 to 21 days were 22 patients (57,89%). The progresive phase 1 to 7 days occured in 17 patients (44,73%), 8 to 14 days also in 17 patients (44,73%).The clinical features were paresthesias followed by weakness to 23 patients (60,52%) and weakness only in 15 patients (39,47%). The pattern of weakness by tetraparese in 5 patients (13,15%) and paraparese in 33 patients (86,84%). The distribution of weakness was more towards the distal extremities then the upper extremities which amounts to 37 patients (97,36%). Laboratories examination of the cerebro spinal fluid revealed protein above 46 mg/dl in 31 patients (81,57%) and below 45 mg/dl in 7 patients (18,42%). One of the patients was on a ventilator because of respiratory muscle paralysis. Complete recovery in this research between 3 to 6 months. Guillain Barre Syndrome is clinically fully recovered although special precautions has to be taken due to the effect towards the respiratory muscle. The characteristic of the laboratory examination is an albuminocytologic dissociation

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“…11 However, to date, no definitive statement can be made regarding these treatments, and therapy remains chiefly symptomatic.…”

Section: Gurlain-barre Syndrome--mentioning

confidence: 99%

Adult-onset muscle weakness

Riggs¹

1985

Postgraduate Medicine

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When adults present with muscle weakness as the predominant symptom and sign, the causes can usually be narrowed down to four disorders: amyotrophic lateral sclerosis, Guillain-Barré syndrome, myasthenia gravis, and inflammatory myopathy. Perhaps the most difficult task for the clinician is identifying which of these patients are actually weak and which are describing generalized fatigue. This task should be made easier by keeping in mind the definition of muscle weakness--a loss of power resulting in reduction of motor function--and by performing careful functional muscle testing.

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Treatment of acute inflammatory polyneuropathy

Cited by 64 publications

References 58 publications

A clinical study of the Guillain-Barré syndrome

A clinical study of the Guillain-Barré syndrome

Manifestasi Klinis Dan Laboratoris Penderita Sindroma Guillain Barre Di Ruang Perawatan Anak Rsu Dr. Saiful Anwar Malang

Adult-onset muscle weakness

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