Treatment of persistent allergic rhinitis via acupuncture at the sphenopalatine acupoint: a randomized controlled trial

Mi, Jiaoping; Chen, Xinye; Lin, Xiaoyan; Guo, Jian-ling; Chen, Hongtao; Liao, Wei; Hong, Haiyu

doi:10.1186/s13063-017-2339-z

Cited by 34 publications

(46 citation statements)

References 20 publications

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“…Sinomenine is one monomer of Chinese traditional herbs and may possess anti-inflammation, anti-oxidation and anti-apoptosis effects (10). Acupuncture is an important therapy used in complementary and alternative medicine, and may exert anti-inflammatory effects (11). Acupuncture targets specific acupoints to improve the body microenvironment and thus effectively treat certain diseases (12,13).…”

Section: Introductionmentioning

confidence: 99%

Combined treatment with sinomenine and acupuncture on collagen‑induced arthritis through the NF‑κB and MAPK signaling pathway

Liu

Wan

et al. 2018

Oncol Lett

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Sinomenine is a monomer extracted from the traditional Chinese medicine plant , which possesses several pharmacological properties including prominent abirritation, mitigation, anti-inflammation, immune suppression, cough relief, stimulation of histamine release, decrease in blood pressure and antiarrhythmia. Sinomenine is clinically employed to treat rheumatic disease. To investigate the impact of combined sinomenine treatment with acupuncture on the progression of arthritis and explore the potential underlying molecular mechanisms, the present study analyzed a collagen-induced arthritis model. Results from the combined curative (CC) treatment group (combined treatment with sinomenine and acupuncture) demonstrated a decrease in volume changes and arthritis score changes within rat paws, and increased the overall body weight in arthritic rats. CC treatment significantly decreased tumor necrosis factor α, interleukin (IL)-6, IL-1β and IL-8 serum levels in arthritic rats. CC treatment significantly increased superoxide dismutase and inhibited malondialdehyde levels in arthritic rats. The protein expression of cyclooxygenase-2, inducible nitric oxide synthase, matrix metalloproteinase (MMP)2 and MMP9 in arthritic rats was suppressed owing to CC treatment. Finally, nuclear factor κB and phosphorylated p38 mitogen-activated protein kinase (MAPK) protein expression in arthritic rats were also suppressed following CC treatment. The results indicate that the combined treatment of sinomenine and acupuncture on collagen-induced arthritis takes effect through the nuclear factor κB and MAPK signaling pathway.

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Section: Introductionmentioning

confidence: 99%

Combined treatment with sinomenine and acupuncture on collagen‑induced arthritis through the NF‑κB and MAPK signaling pathway

Liu

Wan

et al. 2018

Oncol Lett

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“…The majority of the excluded articles were in Chinese‐language journals, and these included 5 randomized controlled trials (RCTs) . Of the 38 English‐language articles, there were 15 RCTs . Included studies are shown in Table .…”

Section: Resultsmentioning

confidence: 99%

“…Of all studied non‐allopathic treatments, acupuncture had the most data to support its use. Fifteen RCTs were present that showed acupuncture to be a useful adjunct to allopathic standard of care as well as being a useful standalone treatment modality for AR . A 2015 English‐language review of both the English and Chinese language literature found 18 RCTs, which highlights the fact that a large portion of the CAM literature is in the non‐English literature .…”

Section: Discussionmentioning

confidence: 99%

Alternative therapies for sinusitis and rhinitis: a systematic review utilizing a modified Delphi method

Gettelfinger

Ting

et al. 2020

Int Forum Allergy Rhinol

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Background Sinusitis and rhinitis are common diseases for which patients seek medical attention. Alternative therapies constitute a multibillion‐dollar industry despite poorly established efficacy and safety profiles. This study was designed to identify and grade the evidence for alternative therapies purported to treat sinusitis and rhinitis. Methods A modified Delphi method was used to establish a consensus opinion among rhinology experts of the current evidence for efficacy, potential harm, and future research needs for alternative therapies in sinusitis and rhinitis. Following the initial Delphi round of discussion, a Google search query was performed to identify topics and review online reports of benefit. Subsequent rounds established search criteria and inclusion/exclusion criteria for a systematic literature review utilizing PubMed, EMBASE, and Cochrane databases. Centre for Evidence‐Based Medicine (CEBM) and Grading of Recommendations, Assessment, Development and Evaluations (GRADE) criteria were used to assess levels of evidence and recommendations. Final Delphi rounds were performed until consensus opinions could be reached. Results Over 60 potential alternative therapies for sinusitis and rhinitis were identified. The literature review included 2066 titles with 220 full‐text articles found to be relevant. Most of the therapies had little to no scientific evidence; however, acupuncture, capsaicin, bromelain, and butterbur extract currently have low to moderate‐high GRADE rating. Allergic rhinitis was the most common disease studied. Conclusion Some alternative therapies show promise as potential treatments for sinusitis and rhinitis, mostly compared to placebo. Comparisons to traditional therapies are lacking. For other alternative therapies, many websites included unsubstantiated claims of benefit and ignored potential side effects for which patients should be warned appropriately.

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“…Allergic rhinitis is a chronic respiratory disease with significant health and psychological burden to patients due to the prolonged disease course [13]. In Sri Lanka, also several people seeking treatments for allergic rhinitis from Ayurvedic hospitals.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of two Ayurvedic dosage forms for allergic rhinitis: Study protocol for an open-label randomized controlled trial

Dahanayake

Perera

Galappaththy

et al. 2020

Trials

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Background: Allergic rhinitis (AR) is an immune response of the nasal mucosa to airborne allergens and involves nasal congestion, watery nasal discharge, itching of the nose, and sneezing. The symptoms of allergic rhinitis may significantly affect a patient's quality of life and can be associated with conditions such as fatigue, headache, cognitive impairment, and sleep disturbances. Various complementary and alternative medicine treatments have been used for this condition in clinical practice. The Ayurveda system of medicine is the most common complementary medicine system practiced in Sri Lanka. The aim of this study is to examine the efficacy and safety of a decoction used in traditional Ayurveda for allergic rhinitis and its ready-to-use freeze dried formulation in comparison to an antihistamine over a period of 4 weeks on relief of symptoms in allergic rhinitis.Study design: This is a three-arm, open-label, non-inferiority, randomized controlled clinical trial enrolling patients with AR. Tamalakyadi decoction containing 12 ingredients (TMD12), used in traditional Ayurveda and its freezedried formulation are the test products. The efficacy and safety of the two Ayurvedic dosage forms will be tested against the antihistamine loratadine. Patients with symptoms of AR will be allocated randomly into the three arms after a 1-week run-in period and the medications will be given orally for 28 days. Total Nasal symptom Score (TNSS) of the patients will be used as the primary efficacy endpoint. TNSS will be recorded and compared between the three arms prior to visit 1, at the end of 28 days, and end of the first and second months of follow-up. Symptom scores of daytime nasal symptoms, night time nasal symptoms, non-nasal symptoms and health-related quality of life questionnaire are used as secondary end points.Discussion: This clinical trial will be able to provide evidence-based scientific data on Ayurvedic dosage form, TMD12, and the freeze-dried formulation in the treatment of allergic rhinitis. This trial is expected to develop capacity to scientifically evaluate various Ayurvedic treatments that are claimed to have efficacy in treatment of various disease conditions.

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Treatment of persistent allergic rhinitis via acupuncture at the sphenopalatine acupoint: a randomized controlled trial

Cited by 34 publications

References 20 publications

Combined treatment with sinomenine and acupuncture on collagen‑induced arthritis through the NF‑κB and MAPK signaling pathway

Combined treatment with sinomenine and acupuncture on collagen‑induced arthritis through the NF‑κB and MAPK signaling pathway

Alternative therapies for sinusitis and rhinitis: a systematic review utilizing a modified Delphi method

Efficacy and safety of two Ayurvedic dosage forms for allergic rhinitis: Study protocol for an open-label randomized controlled trial

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