Treatment of ocular surface squamous neoplasia with Mitomycin C

Gupta, Amrita; Muecke, James

doi:10.1136/bjo.2009.168294

Cited by 73 publications

(60 citation statements)

References 24 publications

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“…A kezelés megindítása előtt meg kell várni a szemfelszín teljes reepithelisatióját. Gupta sebészi excisiót és cryotherapiát követeőn 73 páciensnél alkalmazott a műtétet követően négy-hat hét alatt két-három ciklusban, naponta 4 × 1 0,04%-os MMC szemcseppet, amivel 100%-ban ért el teljes rezolúciót és 56 hónapos átlagos utánkö-vetésnél 0%-ban talált recidívát [40]. Kashkouli sebészi eltávolítást és fagyasztást követően szintén két-három ciklusban adta a 0,04%-os MMC szemcseppet, így 17 pá-ciensből egynél alakult ki recidíva kilenc hónapot köve-tően, de az MMC-kezelést megismételve újbóli recidíva nem alakult ki.…”

Section: MMCunclassified

Szemfelszíni laphám-neoplasia

et al. 2017

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Jelen összefoglalóban a szemfelszíni laphám-neoplasiáról való ismereteket összegzik a szerzők, beleértve ezen daganattípus epidemiológiáját, etiológiáját, patológiáját, klinikai megjelenését és kezelését. A conjunctivalis intraepithelialis neoplasiával és az invazív laphámrákkal kapcsolatos közleményeket tekintették át a szerzők néhány saját eset bemutatásával, amelyek alapján olyan alapvető írást szeretnének közölni, amely részletesen taglalja és bemutatja jelenlegi ismereteinket a szemfelszíni laphám-neoplasiáról. A szemfelszíni laphám-neoplasia a leggyakoribb szemfelszíni malignus tumor, illetve a choroidealis melanoma malignumot és a lymphomát követően a harmadik leggyakoribb okuláris malignoma. Alacsony malignitási potenciálja ellenére előrehaladott stádiumban jelentős látásromláshoz vezethet, sőt akár a szemgolyó eltávolításának szükségessége mellett távoli metasztázis kialakulásakor az életet is veszélyeztetheti. Gyakori recidívaképződés miatt kezelésében elengedhetetlen az intra-és posztoperatív adjuváns kezelési módok ismerete és alkalmazása, valamint a rendszeres kontrollvizsgálat. A szemfelszíni laphám-neoplasia felismerése és adekvát kezelése elengedhetetlen ezen tumortípus progressziójának elkerülésében és a recidíva kialakulásának megelőzésében. Orv Hetil. 2017; 158(51): 2011-2022. Kulcsszavak: conjunctivalis intraepithelialis neoplasia, laphámrák, szemfelszíni laphám-neoplasia Ocular surface squamous neoplasiaTo summarize actual knowledge on epidemiology, etiology, pathology, clinical apparence and treatment of ocular surface squamous neoplasias. We summarize up-to-date literature on conjunctival intraepithelial neoplasia and invasive squamous cell carcinoma and present some own cases. Ocular surface squamous neoplasia is the most common malignant ocular surface tumor and the third most common ocular malignancy following malignant melanoma and lymphoma. In spite of its low malignant potential, in advanced stages it may reduce visual acuity significantly or even the eye globe has to be removed. In case of metastasis it may also be life-threatening. As local recurrences of ocular surface squamous neoplasias may occur, knowledge of intra-and postoperative adjuvant treatment options are indispensable and regular control examinations are necessary. Identification and adequate treatment of ocular surface squamous neoplasias are necessary in order to avoid its progression and to prevent recurrences.

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Section: MMCunclassified

Szemfelszíni laphám-neoplasia

et al. 2017

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“…Since 1994 several groups have reported the use of MMC in the treatment of both primary and recurrent OSSN. [12][13][14][15][16][17] MMC allows treatment of the entire ocular surface including the conjunctival fornices and may reach and destroy subclinical disease and prevent new tumours arising elsewhere on the ocular surface. We think it is unwise to use only MMC without excision biopsy for localised OSSN, as invasive disease may be undiagnosed and MMC is unlikely to penetrate to the required level to reach the invasive cells.…”

Section: Number Of Patients Histopathology Examinationmentioning

confidence: 99%

“…A Gupta, et al 16 concluded that MMC treatment following surgical excision appears to decrease the recurrence rate of localized CCIN and should be considered as adjuvant therapy in primary treatment.…”

Section: Number Of Patients Histopathology Examinationmentioning

confidence: 99%

Clinical Profile of Ocular Surface Squamous Neoplasia: A Retrospective Case Series

Acharya¹,

Ramappa²,

Thomas³

2016

jemds

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AIMTo describe clinical profile and outcome in patients with Ocular Surface Squamous Neoplasia (OSSN). METHODSRetrospective case series. The case records of 11 patients with OSSN over 3 years (2008)(2009)(2010)(2011) with minimum follow up of 6 months were included in the study. Anterior segment findings were documented by slit lamp biomicroscopy. Details of the treatment (Mitomycin and surgery) given to these patients and histopathological report of the excision biopsy were documented. STATISTICAL METHODSFrequency counts with percentage are calculated for anterior segment findings, mode of treatment, Histopathology Examination (HPE) report and recurrence. RESULTSOut of 11 cases of OSSN, 7 cases (63.63%) were males and 4 cases (36.36%) were females. Mean age of patients was 40.45 (18-72) years. Four out of 11 patients (36.36%) were HIV positive. Excision biopsy was done for 6 patients (54.54%) and 5 patients (45.45%) were treated with excision biopsy with local mitomycin C application. On histopathological examination 4/11 (36.36%) had deeper tissue invasion (Invasive squamous cell carcinoma) and 7/11(63.63%) had no invasion of deeper structures. Recurrence was seen in all 4 patients (36.36%) with deeper tissue invasion, which was treated with repeat excision and topical mitomycin C application. CONCLUSIONOSSN is commonly associated with HIV infection. So all suspected cases of OSSN should be screened for HIV infection. Mitomycin-C is a good adjunct to surgical excision, both for primary and recurrent cases.

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“…Aynı zamanda yaygın neoplazilerde preoperatif tümör sınırlarının küçülmesini sağlayarak tam cerrahi eksizyonu mümkün kılabilir. 11,[21][22][23][24][25][26] Florourasil Primidin analoğu olan 5FU hücre siklusunun S fazında DNA sentezini bloke etmek sureti ile etki gösterir. Hızlı proliferasyon gösteren hücreler üzerine etkisi nedeni ile epitel kökenli birçok kanser türünün tedavisinde kullanılmaktadır.…”

Section: Tedaviunclassified

Oküler Yüzey Skuamöz Neoplazilerinde Yeni Gelişmeler

Yağcı¹

2014

tjo

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Konjonktiva skuamoz epitelinden köken alan neoplaziler displaziden skuamoz hücreli karsinoma kadar geniş bir hastalık grubudur. Klinik görünüm olgudan olguya fark gösterebilir. Temel tedavi yöntemi no-touch tekniği ile eksizyonel biopsi olmakla birlikte rekürrensin önlenmesi için ek tedavi yöntemleri uygulanmalıdır. Bu amaçla en yaygın uygulanan yöntemler kriyoterapi ve antimetabolitlerdir. Bu derlemede konjonktiva skuamoz neoplazilerinin klinik görünümü, ayırıcı tanısı, American Joint Committee on Cancer tarafından hazırlanan evrelendirme sistemi ve güncel tedavi yöntemleri sunulmuştur. ( Özet Summary GirişOküler yüzey skuamoz neoplazileri displaziden invaziv skuamoz hücreli karsinoma (SHK) kadar değişen hastalık grubunun genel tanımıdır. Bu tanım içinde yer alan patolojiler skuamoz displazi , skuamoz karsinoma in situ ya da güncel tanımı ile konjonktival intraepitelal neoplazi (KİN), invaziv skuamoz hücreli karsinom olabilir. Skuamoz neoplaziler oküler yüzeyde en sık interpalpebral aralıkta limbal konjonktivadan gelişmeye başlar. Limbal konjonktiva epiteli melanositler ile birlikte oküler yüzeyin en genç hücreleri olan kök hücrelerini içerir. Bu nedenle vücutta mitotik aktivitesi yüksek hücrelerin yoğun bulunduğu diğer bölgeler gibi (serviks uteri) epitel kökenli konjonktiva tümörleri de çoğunlukla kök hücrelerinin yoğun bulunduğu limbus bölgesinde gelişir. Skuamoz neoplaziler tedavi edilmedikleri taktirde lokal invazyon gösterebilen, nadiren uzak metastaz yapan düşük dereceli tümörlerdir. İleri olgularda tüm göz küresi yüzeyi, orbita, nazolakrimal drenaj sistemine, komşu lenf nodüllerine ve nadiren intraoküler kompartmanlara yayılabilir.

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Treatment of ocular surface squamous neoplasia with Mitomycin C

Abstract: Originally published by BMJ -

Cited by 73 publications

References 24 publications

Szemfelszíni laphám-neoplasia

Szemfelszíni laphám-neoplasia

Clinical Profile of Ocular Surface Squamous Neoplasia: A Retrospective Case Series

Oküler Yüzey Skuamöz Neoplazilerinde Yeni Gelişmeler

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