Clinical Profile of Ocular Surface Squamous Neoplasia: A Retrospective Case Series

Abstract

AIMTo describe clinical profile and outcome in patients with Ocular Surface Squamous Neoplasia (OSSN). METHODSRetrospective case series. The case records of 11 patients with OSSN over 3 years (2008)(2009)(2010)(2011) with minimum follow up of 6 months were included in the study. Anterior segment findings were documented by slit lamp biomicroscopy. Details of the treatment (Mitomycin and surgery) given to these patients and histopathological report of the excision biopsy were documented. STATISTICAL METHODSFrequency counts with percentage are calculated for anterior segment findings, mode of treatment, Histopathology Examination (HPE) report and recurrence. RESULTSOut of 11 cases of OSSN, 7 cases (63.63%) were males and 4 cases (36.36%) were females. Mean age of patients was 40.45 (18-72) years. Four out of 11 patients (36.36%) were HIV positive. Excision biopsy was done for 6 patients (54.54%) and 5 patients (45.45%) were treated with excision biopsy with local mitomycin C application. On histopathological examination 4/11 (36.36%) had deeper tissue invasion (Invasive squamous cell carcinoma) and 7/11(63.63%) had no invasion of deeper structures. Recurrence was seen in all 4 patients (36.36%) with deeper tissue invasion, which was treated with repeat excision and topical mitomycin C application. CONCLUSIONOSSN is commonly associated with HIV infection. So all suspected cases of OSSN should be screened for HIV infection. Mitomycin-C is a good adjunct to surgical excision, both for primary and recurrent cases.