Treatment of non-muscle invasive bladder cancer with Bacillus Calmette–Guerin (BCG): Biological markers and simulation studies

Kiselyov, Alex S.; Bunimovich‐Mendrazitsky, Svetlana; Startsev, Vladimir

doi:10.1016/j.bbacli.2015.06.002

Cited by 43 publications

(35 citation statements)

References 84 publications

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“…There is strong evidence that some types of infections and vaccinations might be related with a protective response against solid tumors . In this regard, the greatest success of treatment of cancer with stimuli that can induce reprogramming at the innate immunity level, is the utilization of intravesical BCG as the first option for the treatment of superficial, nonmuscle‐invasive bladder cancer . The antitumor effects of BCG is known since 1929, when a report of necropsies from tuberculosis patients described that the incidence of neoplastic malignancies in tuberculosis patients was significantly lower than in the control group .…”

Section: Clinically Relevant Conditions Of Long‐term Innate Immune Rementioning

confidence: 99%

Long-term reprogramming of the innate immune system

Domínguez‐Andrés

Netea

2018

Journal of Leukocyte Biology

129

131

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During the last few years, a growing body of evidence has shown that immunological memory is not an exclusive trait of lymphocytes, as many inflammatory insults can alter the functionality and the responsiveness of the innate immune system in the long term. Innate immune cells, such as monocytes, macrophages, dendritic cells, and NK cells can be influenced by the encounters with inflammatory stimuli, undergoing functional reprogramming and developing changed responses to subsequent chellenges. The long-term reprogramming depends on the rewiring of cell metabolism and epigenetic processes, and they stay at the basis of induction of both innate immune memory (also termed trained immunity) and innate immune tolerance. Here, we review the central role that the effects of this long-term reprogramming of innate immune cells plays in a number of clinically relevant conditions such as vaccination, atherosclerosis, sepsis, and cancer.

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Section: Clinically Relevant Conditions Of Long‐term Innate Immune Rementioning

confidence: 99%

Long-term reprogramming of the innate immune system

Domínguez‐Andrés

Netea

2018

Journal of Leukocyte Biology

129

131

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“…The relationship between cancer and microbiota has intrigued the biomedical community since the late 19 th century following William Coley's partially successful attempts to cure sarcomas by local injection of bacteria, referred to as ''Coley's toxin.'' Since then, experimental and clinical oncologists have been attempting to isolate microbial agents or products to treat malignant disease with some success, such as treatment of superficial bladder cancer based on an attenuated form of Mycobacterium bovis (Kiselyov et al, 2015), an FDA-approved oncolytic herpes virus for the treatment of melanoma (Greig, 2015), and initial clinical trials exploring treatment of pancreatic cancer with Listeria monocytogenes (Le et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Microbiome and Anticancer Immunosurveillance

Zitvogel

Ayyoub

Routy

et al. 2016

Cell

376

260

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Anticancer immune responses can be considered a desirable form of autoimmunity that may be profoundly shaped by the microbiome. Here, we discuss evidence for the microbiome's influence on anti-tumor immunosurveillance, including those that are indirect and can act at a distance, and we put forward hypotheses regarding mechanisms of how these effects are implemented. These may involve cross-reactivity between microbial and tumor antigens shaping T cell repertoires and/or microbial products stimulating pattern recognition receptors that influence the type and intensity of immune responses. Understanding how the microbiome impacts natural cancer immunosurveillance as well as treatment-induced immune responses will pave the way for more effective therapies and prophylactics.

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“…The most successful therapy for NMIBC consists of serial intravesical instillations of bacillus Calmette-Guerin (BCG; refs. 5,6). This generates multiple immune reactions that diminish the recurrence and progression rate of responder patients.…”

Section: Introductionmentioning

confidence: 99%

BMP4 Induces M2 Macrophage Polarization and Favors Tumor Progression in Bladder Cancer

Martínez

Rubio

Martínez‐Fernández

et al. 2017

Clinical Cancer Research

159

117

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Bladder cancer is a current clinical and social problem. At diagnosis, most patients present with nonmuscle-invasive tumors, characterized by a high recurrence rate, which could progress to muscle-invasive disease and metastasis. Bone morphogenetic protein (BMP)-dependent signaling arising from stromal bladder tissue mediates urothelial homeostasis by promoting urothelial cell differentiation. However, the possible role of BMP ligands in bladder cancer is still unclear. Tumor and normal tissue from 68 patients with urothelial cancer were prospectively collected and analyzed for expression of BMP and macrophage markers. The mechanism of action was assessed by experiments with bladder cancer cell lines and peripheral blood monocyte-derived macrophages. We observed expression is associated and favored type II macrophage differentiation. experiments showed that both recombinant BMP4 and BMP4-containing conditioned media from bladder cancer cell lines favored monocyte/macrophage polarization toward M2 phenotype macrophages, as shown by the expression and secretion of IL10. Using a series of human bladder cancer patient samples, we also observed increased expression of in advanced and undifferentiated tumors in close correlation with epithelial-mesenchymal transition (EMT). However, the p-Smad 1,5,8 staining in tumors showing EMT signs was reduced, due to the increased miR-21 expression leading to reduced expression. These findings suggest that BMP4 secretion by bladder cancer cells provides the M2 signal necessary for a protumoral immune environment. In addition, the repression of by miR-21 makes the tumor cells refractory to the prodifferentiating actions mediated by BMP ligands, favoring tumor growth..

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Treatment of non-muscle invasive bladder cancer with Bacillus Calmette–Guerin (BCG): Biological markers and simulation studies

Cited by 43 publications

References 84 publications

Long-term reprogramming of the innate immune system

Long-term reprogramming of the innate immune system

Microbiome and Anticancer Immunosurveillance

BMP4 Induces M2 Macrophage Polarization and Favors Tumor Progression in Bladder Cancer

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