Long-term reprogramming of the innate immune system

Domínguez‐Andrés, Jorge; Netea, Mihai G.

doi:10.1002/jlb.mr0318-104r

Cited by 130 publications

(141 citation statements)

References 120 publications

(157 reference statements)

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“…The reprogramming of the innate immune cells was observed to last from weeks to months, although the life span of these cells in blood is much shorter than the duration of trained immunity . It is now accepted that innate immune memory can be developed by hematopoietic stem and progenitor cells, providing one explanation for the long‐term effect of trained immunity …”

Section: The Innate Immune System and Innate Immune Memorymentioning

confidence: 99%

Urate‐induced immune programming: Consequences for gouty arthritis and hyperuricemia

Cabău

Crişan

Klück

et al. 2019

Immunological Reviews

156

110

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Trained immunity is a process in which innate immune cells undergo functional reprogramming in response to pathogens or damage‐associated molecules leading to an enhanced non‐specific immune response to subsequent stimulation. While this capacity to respond more strongly to stimuli is beneficial for host defense, in some circumstances it can lead to maladaptive programming and chronic inflammation. Gout is characterized by persistent low‐grade inflammation and is associated with an increased number of comorbidities. Hyperuricemia is the main risk factor for gout and is linked to the development of comorbidities. Several experimental studies have shown that urate can mechanistically alter the inflammatory capacity of myeloid cells, while observational studies have indicated an association of hyperuricemia to a wide spectrum of common adult inflammatory diseases. In this review, we argue that hyperuricemia is a main culprit in the development of the long‐term systemic inflammation seen in gout. We revisit existing evidence for urate‐induced transcriptional and epigenetic reprogramming that could lead to an altered functional state of circulating monocytes consisting in enhanced responsiveness and maladaptive immune responses. By discussing specific functional adaptations of monocytes and macrophages induced by soluble urate or monosodium urate crystals and their contribution to inflammation in vitro and in vivo, we further enforce that urate is a metabolite that can induce innate immune memory and we discuss future research and possible new therapeutic approaches for gout and its comorbidities.

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Section: The Innate Immune System and Innate Immune Memorymentioning

confidence: 99%

Urate‐induced immune programming: Consequences for gouty arthritis and hyperuricemia

Cabău

Crişan

Klück

et al. 2019

Immunological Reviews

156

110

View full text Add to dashboard Cite

show abstract

“…When the body is exposed to pathogen, the first line of defense is innate immune response (Jin, Batra, & Jeyaseelan, ; Taner et al, ). Innate immune includes monocyte–macrophage cells (Dominguez‐Andres & Netea, ) and leukocyte and dendritic cells (DCs; Lee, Park, Van Kaer, Hong, & Hong, ) that play an important role against pathogens (Chen, Peng, Zhou, & Zhuang, ). Because the phagocytic cells are encountered with pathogens, dysregulated immune response (Bangsgaard, Hjorth, Olufsen, Mehlsen, & Ottesen, ) cause to the release of products such as chemokines, cytokine, lipid mediators, nitric oxide (NO), and oxygen radicals (Arango Duque & Descoteaux, ; Markose, Kirkland, Ramachandran, & Henderson, ).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies

Karimi

Ghodsi

Kooshki

et al. 2019

Phytotherapy Research

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Sepsis is a complex disease that begins with an infectious disorder and causes excessive immune responses. Curcumin is considered as an active component of turmeric that can improve the condition in sepsis due to its anti‐inflammatory and antioxidant properties. PubMed, Embase, Google Scholar, Web of Science, and Scopus databases were searched. Searching was not limited to a specific publication period. Only English‐language original articles, which had examined the effect of curcumin on sepsis, were included. At first, 1,098 articles were totally found, and 209 articles were selected after excluding duplicated data; 46 articles were remained due to the curcumin effects on sepsis. These included 23 in vitro studies and 23 animal studies. Our results showed that curcumin and various analogs of curcumin can have an inhibitory effect on sepsis‐induced complications. Curcumin has the ability to inhibit the inflammatory, oxidative coagulation factors, and regulation of immune responses in sepsis. Despite the promising evidence of the therapeutic effects of curcumin on the sepsis complication, further studies seem necessary to investigate its effect and possible mechanisms of action in human studies.

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“…Lymphocytes are equipped with specific receptors to recognize only a particular Ag. After the first exposure to this cognate ligand, they can develop memory properties that result in a quick and more effective response next time these cells encounter the same priming Ag …”

Section: Introductionmentioning

confidence: 99%

Innate-like B cell subsets during immune responses: Beyond antibody production

Romero‐Ramírez

Navarro-Hernandez

Cervantes‐Díaz

et al. 2018

Journal of Leukocyte Biology

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B lymphocytes are recognized for their crucial role in the adaptive immunity since they represent the only leukocyte lineage capable of differentiating into Ab‐secreting cells. However, it has been demonstrated that these lymphocytes can exert several Ab‐independent functions, including engulfing and processing Ags for presentation to T cells, secreting soluble mediators, providing co‐stimulatory signals, and even participating in lymphoid tissues development. Beyond that, several reports claiming the existence of multiple B cell subsets contributing directly to innate immune responses have appeared. These “innate‐like” B lymphocytes, whose phenotype, development pathways, tissue distribution, and functions are in most cases notoriously different from those of conventional B cells, are crucial to early protective responses against pathogens by exerting “crossover” defensive strategies that blur the established boundaries of innate and adaptive branches of immunity. Examples of these mechanisms include the rapid secretion of the polyspecific natural Abs, increased susceptibility to innate receptors‐mediated activation, cytokine secretion, downstream priming of other innate cells, usage of specific variable immunoglobulin gene‐segments, and other features. As these new insights emerge, it is becoming preponderant to redefine the functionality of B cells beyond their classical adaptive‐immune tasks.

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Long-term reprogramming of the innate immune system

Cited by 130 publications

References 120 publications

Urate‐induced immune programming: Consequences for gouty arthritis and hyperuricemia

Urate‐induced immune programming: Consequences for gouty arthritis and hyperuricemia

Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies

Innate-like B cell subsets during immune responses: Beyond antibody production

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