“…6,19,20 10.1080/2162402X.2018.1526614-F0001Figure 1.Complete tumour devascularisation requires permanent disruption of afferent and efferent vasculature. 7,19 First, tumour is isolated (a) and its vascular and lymphatic supply is ligated (b). The ligated tumour is left in situ (c) and the wound is closed (d).…”
Section: Technique Of Complete Tumour Devascularisationmentioning
confidence: 99%
“…7,19 First, tumour is isolated (a) and its vascular and lymphatic supply is ligated (b). The ligated tumour is left in situ (c) and the wound is closed (d).…”
Section: Technique Of Complete Tumour Devascularisationmentioning
confidence: 99%
“…He reported that the majority of these patients recovered completely, including complete regression of distant metastases. 6,7 Regrettably, it is now impossible to verify those studies independently because the surgeries were spread over several decades and the original medical records are lost. In 2001, the work of Dr. Fortýn was ‘discovered’ by the media, triggering a sudden and renewed interest in the method among the Czech public, scientists, and clinicians in the subsequent years.…”
Complete tumour devascularisation (CTD) is a surgical technique which entails the complete disruption by ligation or cutting of afferent and efferent tumour vasculature which remains in situ. In some animal models, CTD induces immune responses that lead to regression of distant metastases and protective immunity.
“…6,19,20 10.1080/2162402X.2018.1526614-F0001Figure 1.Complete tumour devascularisation requires permanent disruption of afferent and efferent vasculature. 7,19 First, tumour is isolated (a) and its vascular and lymphatic supply is ligated (b). The ligated tumour is left in situ (c) and the wound is closed (d).…”
Section: Technique Of Complete Tumour Devascularisationmentioning
confidence: 99%
“…7,19 First, tumour is isolated (a) and its vascular and lymphatic supply is ligated (b). The ligated tumour is left in situ (c) and the wound is closed (d).…”
Section: Technique Of Complete Tumour Devascularisationmentioning
confidence: 99%
“…He reported that the majority of these patients recovered completely, including complete regression of distant metastases. 6,7 Regrettably, it is now impossible to verify those studies independently because the surgeries were spread over several decades and the original medical records are lost. In 2001, the work of Dr. Fortýn was ‘discovered’ by the media, triggering a sudden and renewed interest in the method among the Czech public, scientists, and clinicians in the subsequent years.…”
Complete tumour devascularisation (CTD) is a surgical technique which entails the complete disruption by ligation or cutting of afferent and efferent tumour vasculature which remains in situ. In some animal models, CTD induces immune responses that lead to regression of distant metastases and protective immunity.
“…Metastases are broadly disseminated in various organs and tissues. They are regularly found in the spleen, lymph nodes and lungs (Fort˘n et al 1994;Horák et al 1999). In highly affected minipigs, metastases are found also in various parts of digestive tract, pancreas, liver, kidneys, thymus and other organs (Fort˘n et al 1998).…”
mentioning
confidence: 99%
“…All these results suggest that the MeLiM minipigs are a suitable animal model for study of this cancer disease. Successful experimental therapy of malignant melanoma in the MeLiM minipigs was achieved by devitalization (ischaemization) technique (Fort˘n et al 1994;Horák et al 1999).…”
The aim of the study was to investigate the development of haematological indices in the MeLiM strain of miniature pigs. MeLiM minipigs in group M were affected with hereditary malignant melanoma and received 100 mg Fe 3+ dextran i.m. on day 3 of age. Group H contained melanomafree MeLiM minipigs that were supplemented with iron as in group M. Melanoma-free MeLiM minipigs without iron supplementation till the week 5 of age were included in group A. Development of haematological indices in group H was compared to literature data from other breeds and strains of minipigs. Red blood cell indices in group A were found to be characteristic for hypochromic microcytary anaemia. Higher red blood cell counts were found in animals affected with melanoma (group M) on week 8 of age compared to group H. Pigs in group M showed also lower growth intensity compared to healthy animals (group H).Hereditary melanoma, MeLiM, haemoglobin, packed cell volume, iron
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