“…the part of colon which received the same vascular supply as the tumour (Figure 2). 6,19,20 10.1080/2162402X.2018.1526614-F0001Figure 1.Complete tumour devascularisation requires permanent disruption of afferent and efferent vasculature. 7,19 First, tumour is isolated (a) and its vascular and lymphatic supply is ligated (b).…”
Section: Technique Of Complete Tumour Devascularisationmentioning
confidence: 99%
“…7,19 First, tumour is isolated (a) and its vascular and lymphatic supply is ligated (b). The ligated tumour is left in situ (c) and the wound is closed (d).…”
Section: Technique Of Complete Tumour Devascularisationmentioning
confidence: 99%
“…19,20 A kinetic model has been developed to establish the optimal ratio between devascularised tumour and the remainder of the tumour mass. 19 …”
Section: Technique Of Complete Tumour Devascularisationmentioning
confidence: 99%
“…However, several surgeons have conducted this type of surgery over the past 20 years, but these procedures have been carried out outside of a clinical trial framework, hence only case reports have been published. 19 …”
Complete tumour devascularisation (CTD) is a surgical technique which entails the complete disruption by ligation or cutting of afferent and efferent tumour vasculature which remains in situ. In some animal models, CTD induces immune responses that lead to regression of distant metastases and protective immunity.
“…the part of colon which received the same vascular supply as the tumour (Figure 2). 6,19,20 10.1080/2162402X.2018.1526614-F0001Figure 1.Complete tumour devascularisation requires permanent disruption of afferent and efferent vasculature. 7,19 First, tumour is isolated (a) and its vascular and lymphatic supply is ligated (b).…”
Section: Technique Of Complete Tumour Devascularisationmentioning
confidence: 99%
“…7,19 First, tumour is isolated (a) and its vascular and lymphatic supply is ligated (b). The ligated tumour is left in situ (c) and the wound is closed (d).…”
Section: Technique Of Complete Tumour Devascularisationmentioning
confidence: 99%
“…19,20 A kinetic model has been developed to establish the optimal ratio between devascularised tumour and the remainder of the tumour mass. 19 …”
Section: Technique Of Complete Tumour Devascularisationmentioning
confidence: 99%
“…However, several surgeons have conducted this type of surgery over the past 20 years, but these procedures have been carried out outside of a clinical trial framework, hence only case reports have been published. 19 …”
Complete tumour devascularisation (CTD) is a surgical technique which entails the complete disruption by ligation or cutting of afferent and efferent tumour vasculature which remains in situ. In some animal models, CTD induces immune responses that lead to regression of distant metastases and protective immunity.
“…In this therapy, the tumor is completely devascularized by the ligature of all arteries and veins, and left in situ in the body. This provokes a generalized immune response to tumor antigens, and leads not only to the elimination of the devascularized tumor, but possibly also to the elimination of distant lesions without causing sepsis (2). This technique, formerly termed ‘devitalization’, has been renamed as ‘autologous tumor immunizing devascularization’ (ATID) (2).…”
Colorectal cancer is the third most common cancer. Approximately 20% of patients have at the time of presentation metastasized colorectal cancer, which is incurable in ~80% of cases. The present case report describes a typical case diagnosed with an advanced invasive colorectal adenocarcinoma, with two suspect hypodense lesions in the liver, as revealed by sonography. Judged inoperable for a curative outcome by radical resection, the patient was treated with a novel surgical technique based on stimulating the immune system, termed ‘autologous tumor immunizing devascularization’ (ATID). The tumor was isolated from its surroundings by ligature of arteries and veins, and subsequently the completely devascularized tumor was left in situ. The distal part of the rectum was closed, and a stoma was made from the proximal part of the colon. Following ATID, the stressing pathophysiological condition of the completely isolated tumor provoked a generalized cellular immune response, which led to the elimination of the devascularized tumor and distant lesions without causing sepsis. The patient did not experience any serious side-effects following the operation, and refused any adjuvant chemo- and/or radiotherapy. To date, the patient has no complaints and remains in good health after the ATID intervention, already more than 14 years. The present case study provides a typical demonstration of the clinical safety of ATID, and also indicates both the immunizing and the curative potential of the method.
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