“…Clinical studies show analgesic effects of intravenously administered sodium channel blockers especially in pain conditions where hyperalgesia is prominent [114,139,143,144,276,277,[280][281][282]. Chronic pain conditions, in which reports of IVLT have been beneficial include peripheral nerve injury [283], neuropathic pain [7,16,274,276,279,[284][285][286], CRPS [255,287], headaches [133,288,289], cancer therapy, spinal cord injury [176] and fibromyalgia [290].…”