Treatment of intractable painful diabetic neuropathy with intravenous lignocaine

A Multicentre Open-Label Safety and Efficacy Study of Tetrodotoxin for Cancer Pain

“…In cancer patients with opioid-refractory pain, mean duration of analgesia was 9.3 ± 2.6 days after a single infusion 18 . For intractably painful diabetic neuropathy, intensity of pain was diminished for up to 28 days after an infusion 19 . Trigeminal nerve block with a high dose of lidocaine in patients with trigeminal neuralgia produced complete pain relief in 11 patients 1 day after the block, which lasted for 3-172 weeks 20 .…”

A Review of Intravenous Lidocaine Infusion Therapy for Paediatric Acute and Chronic Pain Management

“…Clinical studies show analgesic effects of intravenously administered sodium channel blockers especially in pain conditions where hyperalgesia is prominent [114,139,143,144,276,277,[280][281][282]. Chronic pain conditions, in which reports of IVLT have been beneficial include peripheral nerve injury [283], neuropathic pain [7,16,274,276,279,[284][285][286], CRPS [255,287], headaches [133,288,289], cancer therapy, spinal cord injury [176] and fibromyalgia [290].…”

An Observational Study on Lignocaine Infusion for Intractable Chronic Pain

“…These challenging patients always been a challenge for physicians. Lignocaine infusion has been reported with some satisfactory response on these challenging, conventional treatment and resistant patients [31][32][33].…”

“…There are several studies which reported pain relief in PDN [31][32][33]. Despite of rapid half-life, the duration of pain relief reported post lignocaine transfusion was up to 28 days [31,32].…”

“…The side effects in high doses of IV lignocaine can be sedation, hypotension and arrhythmia. However, studies found IV lignocaine infusion were very well tolerated and safe [31,32,38]. Lignocaine infusion is often preserved only for patients who have persistent excruciating pain and where other medications are not beneficial.…”