Treatment of inflammatory diseases of the nose and paranasal sinuses from the standpoint of bioregulatory systemic medicine

Abstract

One of the most frequent otorhinolaryngological pathologies is inflammatory diseases of the nose and paranasal sinuses. In Russia, according to the Ministry of Health and Social Development, 15% of adults and 5% of children suffer from chronic rhinosinusitis. According to analysis of medical records, indicators of ENT diseases do not decrease, and long-established treatment regimens prove to be ineffective, despite the large number of different medications. One of the hypotheses existing at the present stage attributes this tendency to the underestimation of the complexity of regulatory systems in the era of reductionism, when the organism is unable to fully adapt to the influence of the environment. In this connection, the concept of bioregulatory systems medicine (BrSM), developed by an international group of scientific experts and clinicians of different specialties, whose underlying principles are the perception of the human being as a complex and integrated system, acquires particular significance. The development of any process is carried out through multilevel interaction between the various systems of the body, the so-called intra-network interactions. According to the views accepted in BrSM, multipurpose therapy is justified to influence different links of pathogenesis. Thus, the bioregulatory approach is multitargeted, i.e., it involves the use of multicomponent drugs affecting the body as a single system. The purpose of this study is to consider treatment regimens for inflammatory diseases of the nose and paranasal sinuses from the perspective of bioregulatory systems medicine. It is concluded that bioregulatory nasal spray therapy is safe and well tolerated, has anti-inflammatory, antiviral, moisturizing effects, and stimulates mucosal regeneration, is combined with other medicines, and is an excellent alternative to traditional methods of treatment, has no side effects and limitations typical of them.