Treatment of hyperlipidemia in cardiac transplant recipients

Bilchick, Kenneth C.; Henrikson, Charles A.; Skojec, Diane V.; Kasper, Edward K.; Blumenthal, Roger S.

doi:10.1016/j.ahj.2004.03.050

Cited by 58 publications

(56 citation statements)

References 64 publications

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“…The hypothesis of these nephrotoxicity as indicated in the present study, has been proposed that CsA alters the balance between vasodilators and vasoconstrictors in kidney with predominance of vasoconstrictors and vascular smooth muscle cells proliferation in the intima and accumulation of cholesterol esters in macrophages that can be transformed in foam cells in vessel wall with narrowing of vessel lumen (Beckman et al, 2002). Several studies indicate that vascular dysfunction induced by CsA results from an increase in vasoconstrictor factors such as endothelin, thromboxane, and angiotensin II and at the same time a reduction of vasodilator factors such as prostacyclin and nitric oxide (NO) (Parra et al, 1998;Markell et al, 1994;Bilchick et al, 2004;Baid et al, 2001;Halliwell and Gutteridge, 1999). Therefore, an imbalance in the release of vasoactive substances is related to renal vasoconstriction.…”

Section: Resultsmentioning

confidence: 99%

Effect of acute and chronic treatment of Cyclosporin A on liver and kidney functions in rats

Elsayed¹,

Bayomy²,

Azab³

2016

J App Pharm Sci

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Cyclosporin A is a compound widely used as an immunosuppressive drug, particularly, in case of kidney transplantation to prevent rejection of transplanted organ. This study aimed to investigate the bad side effect of acute and chronic treatment with cyclosporin A on liver and kidneys by measuring liver enzymes and kidney function tests in serum. Male rats were used as experimental model in this study. The results of this study concluded that, chronic treatment with cycloosprin A leads to increase in serum urea, creatinine, and uric acid significantly compared to control, also, ALT and Alkaline phosphatase activities in serum were increased by chronic administration of cyclosporine A for four weeks. Decrease of serum albumin and total protein were observed significantly compared to control groups.

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Section: Resultsmentioning

confidence: 99%

Effect of acute and chronic treatment of Cyclosporin A on liver and kidney functions in rats

Elsayed¹,

Bayomy²,

Azab³

2016

J App Pharm Sci

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“…Other agents that may be safe to use for hyperlipidemia in cases requiring concomitant cyclosporine treatment are fibrate and niacin [53]. In addition, if a patient on cyclosporine is prescribed simvastatin, its dosage should be reduced [57].…”

Section: Discussionmentioning

confidence: 99%

Rhabdomyolysis after Transplantation: Case Report after Allogeneic Hematopoietic Transplantation and Review of Literature

Milone¹

2017

JSRT

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“…Characterization of the NPC1L1 pathway revealed that ezetimibe specically binds to NPC1L1 and inhibits its sterol transport function, and it is now widely used in combination therapy with statins for management of hypercholesterolemia in the general population [20]. In liver, cardiac and kidney transplant patients, hypercholesterolemia could be e ectively treated with ezetimibe with few side e ects [21][22][23]. e present study suggests that the signi cantly increased expression of NPC1L1 might promote intestinal cholesterol absorption, which might contribute to hypercholesterolemia involved in the development of CR; however, other important aspects of cholesterol metabolism were not studied simultaneously.…”

Section: Discussionmentioning

confidence: 99%

Increased NPC1L1 and serum cholesterol in a chronic rejection rat

Zhu

Zhou²

2011

CIM

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Increased NPC1L1 and serum cholesterol in a chronic rejection rat Abstract Purpose: To measure serum cholesterol and triglyceride levels and NPC1L1 mRNA and protein as an index of cholesterol absorption during the development of chronic rejection (CR) in a rat model of intestinal transplantation.Methods: Rats were randomly divided into two groups: Group 1 (n=20) underwent syngenic Lewis-to-Lewis transplantation and Group 2 (n=20) underwent allogenic F344-toLewis transplantation as well as treatment with FK506. Blood samples and intestinal tissue were procured on the 190th day a er operation. Histological changes were analyzed and the semiquantitative scores of histological parameters were compared. e serum levels of cholesterol and triglyceride were determined. e expression of Niemann-Pick C1 Like 1(NPC1L1) mRNA and protein were analyzed by Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) and immunohistochemistry, respectively.Results: All the animals survived for the 190 days. e appearance and histology of isogra s were almost normal whereas the allogra s displayed thickened bowel wall and mesenteric brosis, concentric intimal thickening and interstitial brosis and in ammatory in ltration. e histology scores displayed a signi cant di erence between the allogra s and isogra s (P<0.001). No di erences were observed for triglycerides for the two groups.e serum cholesterol levels increased signi cantly in the allogenic group in comparison with the syngenic group (P=0.034), while no di erence was observed for triglyceride levels between groups. RT-PCR showed that the expression of NPC1L1 of allogra s increased signi cantly (P=0.004). Immunohistochemistry con rmed RT-PCR ndings.Conclusions: Neointima formation and mesenteric brosis were the dominant pathological features. e increased expression of NPC1L1 might contribute to hypercholesterolemia, which may be involved in the pathogenesis of transplant arteriosclerosis.ORIGINAL RESEARCH

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Treatment of hyperlipidemia in cardiac transplant recipients

Cited by 58 publications

References 64 publications

Effect of acute and chronic treatment of Cyclosporin A on liver and kidney functions in rats

Effect of acute and chronic treatment of Cyclosporin A on liver and kidney functions in rats

Rhabdomyolysis after Transplantation: Case Report after Allogeneic Hematopoietic Transplantation and Review of Literature

Increased NPC1L1 and serum cholesterol in a chronic rejection rat

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