Effect of acute and chronic treatment of Cyclosporin A on liver and kidney functions in rats

Elsayed, Ata Sedik Ibrahim; Bayomy, Mohamed Fathy Farag; Azab, Azab Elsayed

doi:10.7324/japs.2016.60320

Cited by 10 publications

(11 citation statements)

References 27 publications

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“…Supplementation with zingerone decreased the activities of hepatic enzymes near those of the control values, which could be attributed to the ability of zingerone to prevent hepatic damage and dysfunction. Similar hepato-protective indings were observed by previous researchers (Swaroopa et al, 2012;Elsayed et al, 2016;Korolczuk et al, 2016). To con irm the hepatoprotective effect of zingerone, in our present study, the activity of AST & ALT was measured in liver tissues.…”

Section: Figure 1 Andsupporting

confidence: 87%

Zingerone Ameliorates Hepatotoxicity

Julietpoornamathy

Parameswari²

2020

ijrps

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In medical sciences, toxicity is an area wherein extensive studies have been carried to improve the diseases as well as to prevent. So, there is a high requirement for novel and improved alternative therapeutic strategies to manage diseases. The liver is the largest gland in the body, which executes several important mechanisms; it stores minerals and vitamins and releases them in periods of need. The main aim of this study was to give a closer insight into potent non- toxic compounds that is capable of modifying the responses. Animals were divided into five equal groups viz control (Group 1), administered with food and water ad libitum, (Group 2) administered with olive oil, (Group 3) administered with zingerone, (Group 4) administered with concanavalin A, (Group 5) administered with cyclosporine A followed by zingerone. Our results revealed significant changes in liver marker enzymes and liver histology of zingerone treated rats when compared to control rats. A corollary, zingerone has no toxic effect on hepatocytes and was found to be safe at a dose of 10mg/kg b wt and also ameliorates hepatotoxicity.

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Section: Figure 1 Andsupporting

confidence: 87%

Zingerone Ameliorates Hepatotoxicity

Julietpoornamathy

Parameswari²

2020

ijrps

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“…[ 17,22 ] In this model, an initial time‐course study revealed that 25 mg/kg/day of CsA, when given for 28 days, produced a statistically significant increase in the levels of liver and kidney function markers (SGPT, SGOT, bilirubin, serum urea, BUN, and serum creatinine) as a result of hepatocyte and renal cell damage. [ 10,42–44 ] As a change in the levels of these markers beyond 21 days produced mortality, the study was designed till this time. The selection of this time point is in agreement with several other studies evaluating CsA induced organ damage.…”

Section: Discussionmentioning

confidence: 99%

Metformin and silymarin afford protection in cyclosporine A induced hepatorenal toxicity in rat by modulating redox status and inflammation

Vangaveti

Das

Kumar

2020

J Biochem & Molecular Tox

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The use of cyclosporine A (CsA) as an immunosuppressive agent is often limited owing to its hepatotoxic and nephrotoxic properties. The present study was designed to evaluate the protective effect of metformin and silymarin in a rat model of CsA induced hepatorenal toxicity. The study included seven groups of Wistar albino rats (n = 6 per group): normal control, experimental control (CsA alone, 25 mg/kg), CsA + metformin (50 and 500 mg/kg), CsA + silymarin (50 and 200 mg/kg) and CsA + vitamin E (100 mg/kg). All the drugs were given daily for a period of 21 days by oral gavage and their effect was evaluated on serum levels of organ function markers (serum glutamate pyruvate transaminase, serum glutamate oxaloacetate transaminase, bilirubin, urea/blood urea nitrogen, creatinine), markers of oxidative stress (thiobarbituric acid reactive substances, glutathione, superoxide dismutase), inflammation (nitrite, myeloperoxidase, tumour necrosis factor‐alpha, prostaglandin E2), apoptosis (terminal deoxynucleotidyl transferase dUTP nick end labelling positivity) in addition to tissue histology, cyclooxygenase (COX)‐2 and inducible nitric oxide synthase (iNOS) immunoreactivity. Administration of metformin and silymarin along with CsA ameliorated functional damage to liver and kidneys in a dose‐dependent manner. Significant and comparable improvement in the tissue levels of oxidative stress, inflammation, apoptotic markers was also observed following treatment with both the test drugs. Normalization of histology scores, as well as COX‐2 and iNOS immunoreactivity scores, further strengthened these findings. The hepatoprotective and nephroprotective effects of metformin and silymarin were comparable and matched with that of reference drug, vitamin E. The findings of the present study suggest that both metformin and silymarin have a potential for clinical use in patients receiving long‐term CsA treatment to maintain their liver and kidney functions.

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“…A steady decrease in hepatic protein levels with higher doses of ACR could be attributed to retarded protein synthesis, change in protein metabolism, or to the leakage of protein reserves from hepatocytes (Asha et al, 2008). Significant decrease of serum albumin and TSP were noticed after 2 weeks of treatment with Cys (Elsayed et al, 2016) that indicated hepatotoxicity (Kienhuis et al, 2013 Significant elevation in serum GSH and depression in peroxynitrite radical concentration after oral intubation of Salvia officinalis indicated its antioxidant capacity. Antioxidant and free radical scavenging activity of alcoholic and water extract of SO were studied in vivo (Oboh and Henle, 2009) and in vitro (Wielgus et al, 2011;Petrova et al, 2015) study as well as in SO nanoparticles (Wagdy and Faiza, 2013), Carnosic acid, carvacrol, thymol (Tenor et al, 2011) α-thujone and camphor (Pop et al, 2014) as well as rosmarinic acid and its dimer (salvianolic acid), showed a high antioxidant activity and is a very significant scavenger of free radicals (Hamidpour et al, 2014).…”

Section: Ne Usmentioning

confidence: 99%