Cyclosporin A is a compound widely used as an immunosuppressive drug, particularly, in case of kidney transplantation to prevent rejection of transplanted organ. This study aimed to investigate the bad side effect of acute and chronic treatment with cyclosporin A on liver and kidneys by measuring liver enzymes and kidney function tests in serum. Male rats were used as experimental model in this study. The results of this study concluded that, chronic treatment with cycloosprin A leads to increase in serum urea, creatinine, and uric acid significantly compared to control, also, ALT and Alkaline phosphatase activities in serum were increased by chronic administration of cyclosporine A for four weeks. Decrease of serum albumin and total protein were observed significantly compared to control groups.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.