Treatment of gingivitis with hyaluronan

Aim: Aim of the present study was to evaluate the adjunctive effect of local application of hyaluronon gel following scaling and root planing (SRP) in chronic periodontitis patients. Materials and Methods:In this randomized split mouth study 33 subjects with chronic periodontitis were evaluated after full mouth SRP. In the test sites hyaluronon gel was applied immediately after SRP and one week post therapy, the control sites were treated with SRP alone. Bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment level (CAL) were recorded at baseline, 4 wk and 12 wk.Results: Significant reduction in BOP scores was observed in both the groups at 12weeks (p<0.001). The hyaluronon group

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“…Jentsch et al in their study found that adjunctive application of hyaluronon significantly reduced gingivitis [30].…”

Section: Discussionmentioning

confidence: 99%

Hyaluronic Acid as an Adjunct to Scaling and Root Planing in Chronic Periodontitis. A Randomized Clinical Trail

Padma

Baramappa

Rao

et al. 2014

JCDR

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“…Hyaluronan gel is also effective in controlling inflammation and gingival bleeding, as shown by a study of Mesa et al that documented reduction in the depth of gingival pockets along with a significant decrease in epithelial and lymphocyte cell proliferation after the use of HA gel [384]. Similarly, 0.2 % hyaluronan containing gel has a benefic effect on the treatment of plaque induced gingivitis due to the significant decrease in peroxidase and lysozyme activities [383]. In addition, De Arau'jo Nobre found that HA and chlorhexidine maintain a healthy perimplant complex in immediate function implants for complete rehabilitations in the edentulous mandible [385].…”

Section: Proteins and Poly(amino Acids)mentioning

confidence: 89%

“…Pistorius et al evaluated the efficacy of topical application of HA for treatment of gingivitis and found that HA containing preparations are a useful adjunct in the anti-gingival therapy [382]. A commercialized gel formulation, Gengigel ® (Ricerfarma S.r.l., Milano, Italy), contains high molecular weight 0.2 % fractions of HA , for its effect in the treatment of plaque induced gingivitis as an adjunct [383]. Hyaluronan gel is also effective in controlling inflammation and gingival bleeding, as shown by a study of Mesa et al that documented reduction in the depth of gingival pockets along with a significant decrease in epithelial and lymphocyte cell proliferation after the use of HA gel [384].…”

Section: Proteins and Poly(amino Acids)mentioning

confidence: 99%

“…Table 11 summarizes polysaccharides based devices used for dentistry. [379][380][381][382][383][384] Gengigel ® [383] HA and chlorhexidine complexes [385] Autologous bone combined with esterified low molecular HA preparation [386] Fibrous esterified HA [387,388] CHS Three-dimensional silk fibroin/gelatinchondroitin sulfate-hyaluronic acid scaffolds [396] …”

Section: Proteins and Poly(amino Acids)mentioning

confidence: 99%

See 1 more Smart Citation

Biodegradable polymers for dental tissue engineering and regeneration

Conte¹,

Riccitiello²,

Luise³

et al. 2017

Biodegradable Polymers: Recent Developments and New Perspectives

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“…HA has an anti-inflammatory effect acting as a scavenger which drain, metalloproteinases, prostaglandins and others which promote inflammatory activities (24) . The anti-edematous property of HA also may be related to its osmotic properties (25) . HA regulates the inflammatory and immune response acting as an anti-oxidant so, HA may stabilize the granulation tissue matrix (26) .…”

Section: …………………………………………………………………………………………………… Introduction:-mentioning

confidence: 99%

Evaluation of Topical Subgingival Application of Hyaluronic Acid (Ha) Gel Adjunctive to Scaling and Root Planing (Srp) in the Treatment of Chronic Periodontitis.

Kandil¹,

Khashaba²,

El-Daker³

et al. 2017

IJAR

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Objective: The aim of this study is to assess effect of sub-gingival application of hyaluronic acid (HA) gel .8% adjunctive to non-mechanical debridement in treatment of chronic periodontitis based on clinical scoring and microbiological study. Subjects and Methods: The present study was carried out on 20 patients with chronic periodontitis with at least two quadrants with pocket depth ≥5 mm within the same arch. Split-mouth study design was used where control side received (SRP) only and study side received both (SRP) and subgingival application of high molecular weight 0.8% hyaluronic acid gel in a 3 months follow-up study. After clinical assessment and plaque sample collection all patients received full mouth SRP in both study and control sites at the baseline, 2 nd , 4 th and 6 th weeks. Study sites additionally received 0.8% HMW HA gel sub-gingivally till the depth of pocket, this done once a week starting at the baseline then repeated at weeks 1, 2, 3, 4, 5 and 6 for a total seven applications. Subgingival plaque samples were collected prior to clinical measurements from both study and control sites at the baseline, 6 th and 12 th weeks for PCR examination. Evaluation included clinical and microbiological parameters that recorded at the base line, th 6 th and then in 12 th week. Clinical parameters included: Plaque index (PI), Gingival index(GI), Periodontal probing depths (PPD), Clinical attachment loss (CAL) and clinical attachment regain where, micriobiological assessment included qualitative polymerase chain reaction (PCR) for detection of both provotella intermedia and porphyromonus gingivalis in both sides . Results: In the present study, there were highly significant clinical improvements in all measured clinical

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Treatment of gingivitis with hyaluronan

Abstract: These data suggest that a hyaluronan containing gel has a beneficial effect in the treatment of plaque-induced gingivitis.

Cited by 110 publications

References 36 publications

Hyaluronic Acid as an Adjunct to Scaling and Root Planing in Chronic Periodontitis. A Randomized Clinical Trail

Hyaluronic Acid as an Adjunct to Scaling and Root Planing in Chronic Periodontitis. A Randomized Clinical Trail

Biodegradable polymers for dental tissue engineering and regeneration

Evaluation of Topical Subgingival Application of Hyaluronic Acid (Ha) Gel Adjunctive to Scaling and Root Planing (Srp) in the Treatment of Chronic Periodontitis.

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