Biodegradable polymers for dental tissue engineering and regeneration

Conte, Romana; Riccitiello, Francesco; Luise, Adriana De; Petillo, Orsolina; Rengo, Carlo; Salle, Anna Di; Calarco, Anna; Peluso, Gianfranco

doi:10.5599/obp.14.5

Cited by 4 publications

(4 citation statements)

References 378 publications

(402 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nowadays, biodegradable polymers such as aliphatic polyesters have replaced traditional non-degradable materials for biomedical application due to their ability to degrade and be absorbed by the body without elicit adverse effects [ 36 , 37 ]. Among them, electrospun PLA-based nanofibers represent one of the most promising drug release systems because of their superior chemical and mechanical properties, their versatility in fabrication, biodegradability, and compatibility with biomolecules and cells [ 38 ].…”

Section: Resultsmentioning

confidence: 99%

pH-Responsive Resveratrol-Loaded Electrospun Membranes for the Prevention of Implant-Associated Infections

Bonadies

Cristo²,

Valentino³

et al. 2020

Nanomaterials

Self Cite

View full text Add to dashboard Cite

To date, the implant-associated infections represent a worldwide challenge for the recently reported bacterial drug resistance that can lead to the inefficacy or low efficacy of conventional antibiotic therapies. Plant polyphenolic compounds, including resveratrol (RSV), are increasingly gaining consensus as valid and effective alternatives to antibiotics limiting antibiotic resistance. In this study, electrospun polylactic acid (PLA) membranes loaded with different concentrations of RSV are synthesized and characterized in their chemical, morphological, and release features. The obtained data show that the RSV release rate from the PLA-membranes is remarkably higher in acidic conditions than at neutral pH. In addition, a change in pH from neutral to slightly acidic triggers a significant increase in the RSV release. This behavior indicates that the PLA-RSV membranes can act as drug reservoir when the environmental pH is neutral, starting to release the bioactive molecules when the pH decreases, as in presence of oral bacterial infection. Indeed, our results demonstrate that PLA-RSV2 displays a significant antibacterial and antibiofilm activity against two bacterial strains, Pseudomonas aeruginosa PAO1, and Streptococcus mutans, responsible for both acute and chronic infections in humans, thus representing a promising solution for the prevention of the implant-associated infections.

show abstract

Section: Resultsmentioning

confidence: 99%

pH-Responsive Resveratrol-Loaded Electrospun Membranes for the Prevention of Implant-Associated Infections

Bonadies

Cristo²,

Valentino³

et al. 2020

Nanomaterials

Self Cite

View full text Add to dashboard Cite

show abstract

“…It was revealed that the first stage of healing after the extraction is similar regardless of adding collagen to the socket, but the quality of bone after 4 months postoperatively is much better after the application of collagen [ 43 , 44 ]. Collagen membranes are also very useful for periodontal procedures of guided tissue regeneration [ 45 , 46 ]. Collagen is characterized by biocompatibility as well as low immunogenicity and cytotoxicity.…”

Section: Chemical Classification and Biological Activity Of Natural Dental Polymersmentioning

confidence: 99%

Natural Polymers for the Maintenance of Oral Health: Review of Recent Advances and Perspectives

Paradowska-Stolarz

Więckiewicz

Owczarek

et al. 2021

IJMS

View full text Add to dashboard Cite

The success of modern dental treatment is strongly dependent on the materials used both temporarily and permanently. Among all dental materials, polymers are a very important class with a wide spectrum of applications. This review aims to provide a state-of-the-art overview of the recent advances in the field of natural polymers used to maintain or restore oral health. It focuses on the properties of the most common proteins and polysaccharides of natural origin in terms of meeting the specific biological requirements in the increasingly demanding field of modern dentistry. The use of naturally derived polymers in different dental specialties for preventive and therapeutic purposes has been discussed. The major fields of application cover caries and the management of periodontal diseases, the fabrication of membranes and scaffolds for the regeneration of dental structures, the manufacturing of oral appliances and dentures as well as providing systems for oral drug delivery. This paper also includes a comparative characteristic of natural and synthetic dental polymers. Finally, the current review highlights new perspectives, possible future advancements, as well as challenges that may be encountered by researchers in the field of dental applications of polymers of natural origin.

show abstract

“…Polymer-based scaffolds are another option, being inexpensive, reproducible, and exhibiting great mechanical strength, though most are not osteogenic [ 9 ]. Biodegradable polymers are usually non-toxic, induce a low inflammation response, and have relevant mechanical properties and appropriate permeability [ 10 ]. Two biodegradable polymers commonly used in 3D printing are polycaprolactone (PCL) and polylactic acid (PLA) [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Solvent-Free PCL/β-TCP Composite Fiber for 3D Printing: Physiochemical and Biological Investigation

Ngo

Lee

et al. 2023

Polymers

View full text Add to dashboard Cite

Manufacturing three-dimensional (3D) objects with polymers/bioceramic composite materials has been investigated in recent years. In this study, we manufactured and evaluated solvent-free polycaprolactone (PCL) and beta-tricalcium phosphate (β-TCP) composite fiber as a scaffold material for 3D printing. To investigate the optimal ratio of feedstock material for 3D printing, the physical and biological characteristics of four different ratios of β-TCP compounds mixed with PCL were investigated. PCL/β-TCP ratios of 0 wt.%, 10 wt.%, 20 wt.%, and 30 wt.% were fabricated, with PCL melted at 65 °C and blended with β-TCP with no solvent added during the fabrication process. Electron microscopy revealed an even distribution of β-TCP in the PCL fibers, while Fourier transform infrared spectroscopy demonstrated that the biomaterial compounds remained intact after the heating and manufacturing process. In addition, adding 20% β-TCP into the PCL/β-TCP mixture significantly increased hardness and Young’s Modulus by 10% and 26.5%, respectively, suggesting that PCL-20 has better resistance to deformation under load. Cell viability, alkaline phosphatase (ALPase) activity, osteogenic gene expression, and mineralization were also observed to increase according to the amount of β-TCP added. Cell viability and ALPase activity were 20% higher with PCL-30, while upregulation for osteoblast-related gene expression was better with PCL-20. In conclusion, PCL-20 and PCL-30 fibers fabricated without solvent exhibited excellent mechanical properties, high biocompatibility, and high osteogenic ability, making them promising materials for 3D printing customized bone scaffolds promptly, sustainably, and cost-effectively.

show abstract

Biodegradable polymers for dental tissue engineering and regeneration

Cited by 4 publications

References 378 publications

pH-Responsive Resveratrol-Loaded Electrospun Membranes for the Prevention of Implant-Associated Infections

pH-Responsive Resveratrol-Loaded Electrospun Membranes for the Prevention of Implant-Associated Infections

Natural Polymers for the Maintenance of Oral Health: Review of Recent Advances and Perspectives

Fabrication of Solvent-Free PCL/β-TCP Composite Fiber for 3D Printing: Physiochemical and Biological Investigation

Contact Info

Product

Resources

About